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Molecular Mechanisms of Reconsolidation-Dependent Memory Updating

Memory is not a stable record of experience, but instead is an ongoing process that allows existing memories to be modified with new information through a reconsolidation-dependent updating process. For a previously stable memory to be updated, the memory must first become labile through a process c...

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Detalles Bibliográficos
Autores principales: Bellfy, Lauren, Kwapis, Janine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555418/
https://www.ncbi.nlm.nih.gov/pubmed/32916796
http://dx.doi.org/10.3390/ijms21186580
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author Bellfy, Lauren
Kwapis, Janine L.
author_facet Bellfy, Lauren
Kwapis, Janine L.
author_sort Bellfy, Lauren
collection PubMed
description Memory is not a stable record of experience, but instead is an ongoing process that allows existing memories to be modified with new information through a reconsolidation-dependent updating process. For a previously stable memory to be updated, the memory must first become labile through a process called destabilization. Destabilization is a protein degradation-dependent process that occurs when new information is presented. Following destabilization, a memory becomes stable again through a protein synthesis-dependent process called restabilization. Much work remains to fully characterize the mechanisms that underlie both destabilization and subsequent restabilization, however. In this article, we briefly review the discovery of reconsolidation as a potential mechanism for memory updating. We then discuss the behavioral paradigms that have been used to identify the molecular mechanisms of reconsolidation-dependent memory updating. Finally, we outline what is known about the molecular mechanisms that support the memory updating process. Understanding the molecular mechanisms underlying reconsolidation-dependent memory updating is an important step toward leveraging this process in a therapeutic setting to modify maladaptive memories and to improve memory when it fails.
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spelling pubmed-75554182020-10-19 Molecular Mechanisms of Reconsolidation-Dependent Memory Updating Bellfy, Lauren Kwapis, Janine L. Int J Mol Sci Review Memory is not a stable record of experience, but instead is an ongoing process that allows existing memories to be modified with new information through a reconsolidation-dependent updating process. For a previously stable memory to be updated, the memory must first become labile through a process called destabilization. Destabilization is a protein degradation-dependent process that occurs when new information is presented. Following destabilization, a memory becomes stable again through a protein synthesis-dependent process called restabilization. Much work remains to fully characterize the mechanisms that underlie both destabilization and subsequent restabilization, however. In this article, we briefly review the discovery of reconsolidation as a potential mechanism for memory updating. We then discuss the behavioral paradigms that have been used to identify the molecular mechanisms of reconsolidation-dependent memory updating. Finally, we outline what is known about the molecular mechanisms that support the memory updating process. Understanding the molecular mechanisms underlying reconsolidation-dependent memory updating is an important step toward leveraging this process in a therapeutic setting to modify maladaptive memories and to improve memory when it fails. MDPI 2020-09-09 /pmc/articles/PMC7555418/ /pubmed/32916796 http://dx.doi.org/10.3390/ijms21186580 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bellfy, Lauren
Kwapis, Janine L.
Molecular Mechanisms of Reconsolidation-Dependent Memory Updating
title Molecular Mechanisms of Reconsolidation-Dependent Memory Updating
title_full Molecular Mechanisms of Reconsolidation-Dependent Memory Updating
title_fullStr Molecular Mechanisms of Reconsolidation-Dependent Memory Updating
title_full_unstemmed Molecular Mechanisms of Reconsolidation-Dependent Memory Updating
title_short Molecular Mechanisms of Reconsolidation-Dependent Memory Updating
title_sort molecular mechanisms of reconsolidation-dependent memory updating
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555418/
https://www.ncbi.nlm.nih.gov/pubmed/32916796
http://dx.doi.org/10.3390/ijms21186580
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