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Stearoyl-CoA Desaturase 1 Activity Determines the Maintenance of DNMT1-Mediated DNA Methylation Patterns in Pancreatic β-Cells

Metabolic stress, such as lipotoxicity, affects the DNA methylation profile in pancreatic β-cells and thus contributes to β-cell failure and the progression of type 2 diabetes (T2D). Stearoyl-CoA desaturase 1 (SCD1) is a rate-limiting enzyme that is involved in monounsaturated fatty acid synthesis,...

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Detalles Bibliográficos
Autores principales:	Dobosz, Aneta M., Janikiewicz, Justyna, Borkowska, Anna M., Dziewulska, Anna, Lipiec, Ewelina, Dobrzyn, Pawel, Kwiatek, Wojciech M., Dobrzyn, Agnieszka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555428/ https://www.ncbi.nlm.nih.gov/pubmed/32961871 http://dx.doi.org/10.3390/ijms21186844

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