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Protein Dynamics in F-like Bacterial Conjugation

Efficient in silico development of novel antibiotics requires high-resolution, dynamic models of drug targets. As conjugation is considered the prominent contributor to the spread of antibiotic resistance genes, targeted drug design to disrupt vital components of conjugative systems has been propose...

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Autores principales: Bragagnolo, Nicholas, Rodriguez, Christina, Samari-Kermani, Naveed, Fours, Alice, Korouzhdehi, Mahboubeh, Lysenko, Rachel, Audette, Gerald F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555446/
https://www.ncbi.nlm.nih.gov/pubmed/32961700
http://dx.doi.org/10.3390/biomedicines8090362
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author Bragagnolo, Nicholas
Rodriguez, Christina
Samari-Kermani, Naveed
Fours, Alice
Korouzhdehi, Mahboubeh
Lysenko, Rachel
Audette, Gerald F.
author_facet Bragagnolo, Nicholas
Rodriguez, Christina
Samari-Kermani, Naveed
Fours, Alice
Korouzhdehi, Mahboubeh
Lysenko, Rachel
Audette, Gerald F.
author_sort Bragagnolo, Nicholas
collection PubMed
description Efficient in silico development of novel antibiotics requires high-resolution, dynamic models of drug targets. As conjugation is considered the prominent contributor to the spread of antibiotic resistance genes, targeted drug design to disrupt vital components of conjugative systems has been proposed to lessen the proliferation of bacterial antibiotic resistance. Advancements in structural imaging techniques of large macromolecular complexes has accelerated the discovery of novel protein-protein interactions in bacterial type IV secretion systems (T4SS). The known structural information regarding the F-like T4SS components and complexes has been summarized in the following review, revealing a complex network of protein-protein interactions involving domains with varying degrees of disorder. Structural predictions were performed to provide insight on the dynamicity of proteins within the F plasmid conjugative system that lack structural information.
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spelling pubmed-75554462020-10-19 Protein Dynamics in F-like Bacterial Conjugation Bragagnolo, Nicholas Rodriguez, Christina Samari-Kermani, Naveed Fours, Alice Korouzhdehi, Mahboubeh Lysenko, Rachel Audette, Gerald F. Biomedicines Review Efficient in silico development of novel antibiotics requires high-resolution, dynamic models of drug targets. As conjugation is considered the prominent contributor to the spread of antibiotic resistance genes, targeted drug design to disrupt vital components of conjugative systems has been proposed to lessen the proliferation of bacterial antibiotic resistance. Advancements in structural imaging techniques of large macromolecular complexes has accelerated the discovery of novel protein-protein interactions in bacterial type IV secretion systems (T4SS). The known structural information regarding the F-like T4SS components and complexes has been summarized in the following review, revealing a complex network of protein-protein interactions involving domains with varying degrees of disorder. Structural predictions were performed to provide insight on the dynamicity of proteins within the F plasmid conjugative system that lack structural information. MDPI 2020-09-19 /pmc/articles/PMC7555446/ /pubmed/32961700 http://dx.doi.org/10.3390/biomedicines8090362 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bragagnolo, Nicholas
Rodriguez, Christina
Samari-Kermani, Naveed
Fours, Alice
Korouzhdehi, Mahboubeh
Lysenko, Rachel
Audette, Gerald F.
Protein Dynamics in F-like Bacterial Conjugation
title Protein Dynamics in F-like Bacterial Conjugation
title_full Protein Dynamics in F-like Bacterial Conjugation
title_fullStr Protein Dynamics in F-like Bacterial Conjugation
title_full_unstemmed Protein Dynamics in F-like Bacterial Conjugation
title_short Protein Dynamics in F-like Bacterial Conjugation
title_sort protein dynamics in f-like bacterial conjugation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555446/
https://www.ncbi.nlm.nih.gov/pubmed/32961700
http://dx.doi.org/10.3390/biomedicines8090362
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