Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis

Bulbar deterioration in amyotrophic lateral sclerosis (ALS) is a devastating characteristic that impairs patients’ ability to communicate, and is linked to shorter survival. The existing clinical instruments for assessing bulbar function lack sensitivity to early changes. In this paper, using a coho...

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Autores principales: Stegmann, Gabriela M., Hahn, Shira, Liss, Julie, Shefner, Jeremy, Rutkove, Seward, Shelton, Kerisa, Duncan, Cayla Jessica, Berisha, Visar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555482/
https://www.ncbi.nlm.nih.gov/pubmed/33083567
http://dx.doi.org/10.1038/s41746-020-00335-x
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author Stegmann, Gabriela M.
Hahn, Shira
Liss, Julie
Shefner, Jeremy
Rutkove, Seward
Shelton, Kerisa
Duncan, Cayla Jessica
Berisha, Visar
author_facet Stegmann, Gabriela M.
Hahn, Shira
Liss, Julie
Shefner, Jeremy
Rutkove, Seward
Shelton, Kerisa
Duncan, Cayla Jessica
Berisha, Visar
author_sort Stegmann, Gabriela M.
collection PubMed
description Bulbar deterioration in amyotrophic lateral sclerosis (ALS) is a devastating characteristic that impairs patients’ ability to communicate, and is linked to shorter survival. The existing clinical instruments for assessing bulbar function lack sensitivity to early changes. In this paper, using a cohort of N = 65 ALS patients who provided regular speech samples for 3–9 months, we demonstrated that it is possible to remotely detect early speech changes and track speech progression in ALS via automated algorithmic assessment of speech collected digitally.
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spelling pubmed-75554822020-10-19 Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis Stegmann, Gabriela M. Hahn, Shira Liss, Julie Shefner, Jeremy Rutkove, Seward Shelton, Kerisa Duncan, Cayla Jessica Berisha, Visar NPJ Digit Med Brief Communication Bulbar deterioration in amyotrophic lateral sclerosis (ALS) is a devastating characteristic that impairs patients’ ability to communicate, and is linked to shorter survival. The existing clinical instruments for assessing bulbar function lack sensitivity to early changes. In this paper, using a cohort of N = 65 ALS patients who provided regular speech samples for 3–9 months, we demonstrated that it is possible to remotely detect early speech changes and track speech progression in ALS via automated algorithmic assessment of speech collected digitally. Nature Publishing Group UK 2020-10-13 /pmc/articles/PMC7555482/ /pubmed/33083567 http://dx.doi.org/10.1038/s41746-020-00335-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Stegmann, Gabriela M.
Hahn, Shira
Liss, Julie
Shefner, Jeremy
Rutkove, Seward
Shelton, Kerisa
Duncan, Cayla Jessica
Berisha, Visar
Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis
title Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis
title_full Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis
title_fullStr Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis
title_full_unstemmed Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis
title_short Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis
title_sort early detection and tracking of bulbar changes in als via frequent and remote speech analysis
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555482/
https://www.ncbi.nlm.nih.gov/pubmed/33083567
http://dx.doi.org/10.1038/s41746-020-00335-x
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