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3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures
This study evaluated the mechanical properties and bone regeneration ability of 3D-printed pure hydroxyapatite (HA)/tricalcium phosphate (TCP) pure ceramic scaffolds with variable pore architectures. A digital light processing (DLP) 3D printer was used to construct block-type scaffolds containing on...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555666/ https://www.ncbi.nlm.nih.gov/pubmed/32971749 http://dx.doi.org/10.3390/ijms21186942 |
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author | Lim, Ho-Kyung Hong, Seok-Jin Byeon, Sun-Ju Chung, Sung-Min On, Sung-Woon Yang, Byoung-Eun Lee, Jong-Ho Byun, Soo-Hwan |
author_facet | Lim, Ho-Kyung Hong, Seok-Jin Byeon, Sun-Ju Chung, Sung-Min On, Sung-Woon Yang, Byoung-Eun Lee, Jong-Ho Byun, Soo-Hwan |
author_sort | Lim, Ho-Kyung |
collection | PubMed |
description | This study evaluated the mechanical properties and bone regeneration ability of 3D-printed pure hydroxyapatite (HA)/tricalcium phosphate (TCP) pure ceramic scaffolds with variable pore architectures. A digital light processing (DLP) 3D printer was used to construct block-type scaffolds containing only HA and TCP after the polymer binder was completely removed by heat treatment. The compressive strength and porosity of the blocks with various structures were measured; scaffolds with different pore sizes were implanted in rabbit calvarial models. The animals were observed for eight weeks, and six animals were euthanized in the fourth and eighth weeks. Then, the specimens were evaluated using radiological and histological analyses. Larger scaffold pore sizes resulted in enhanced bone formation after four weeks (p < 0.05). However, in the eighth week, a correlation between pore size and bone formation was not observed (p > 0.05). The findings showed that various pore architectures of HA/TCP scaffolds can be achieved using DLP 3D printing, which can be a valuable tool for optimizing bone-scaffold properties for specific clinical treatments. As the pore size only influenced bone regeneration in the initial stage, further studies are required for pore-size optimization to balance the initial bone regeneration and mechanical strength of the scaffold. |
format | Online Article Text |
id | pubmed-7555666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75556662020-10-19 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures Lim, Ho-Kyung Hong, Seok-Jin Byeon, Sun-Ju Chung, Sung-Min On, Sung-Woon Yang, Byoung-Eun Lee, Jong-Ho Byun, Soo-Hwan Int J Mol Sci Article This study evaluated the mechanical properties and bone regeneration ability of 3D-printed pure hydroxyapatite (HA)/tricalcium phosphate (TCP) pure ceramic scaffolds with variable pore architectures. A digital light processing (DLP) 3D printer was used to construct block-type scaffolds containing only HA and TCP after the polymer binder was completely removed by heat treatment. The compressive strength and porosity of the blocks with various structures were measured; scaffolds with different pore sizes were implanted in rabbit calvarial models. The animals were observed for eight weeks, and six animals were euthanized in the fourth and eighth weeks. Then, the specimens were evaluated using radiological and histological analyses. Larger scaffold pore sizes resulted in enhanced bone formation after four weeks (p < 0.05). However, in the eighth week, a correlation between pore size and bone formation was not observed (p > 0.05). The findings showed that various pore architectures of HA/TCP scaffolds can be achieved using DLP 3D printing, which can be a valuable tool for optimizing bone-scaffold properties for specific clinical treatments. As the pore size only influenced bone regeneration in the initial stage, further studies are required for pore-size optimization to balance the initial bone regeneration and mechanical strength of the scaffold. MDPI 2020-09-22 /pmc/articles/PMC7555666/ /pubmed/32971749 http://dx.doi.org/10.3390/ijms21186942 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lim, Ho-Kyung Hong, Seok-Jin Byeon, Sun-Ju Chung, Sung-Min On, Sung-Woon Yang, Byoung-Eun Lee, Jong-Ho Byun, Soo-Hwan 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures |
title | 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures |
title_full | 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures |
title_fullStr | 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures |
title_full_unstemmed | 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures |
title_short | 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures |
title_sort | 3d-printed ceramic bone scaffolds with variable pore architectures |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555666/ https://www.ncbi.nlm.nih.gov/pubmed/32971749 http://dx.doi.org/10.3390/ijms21186942 |
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