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3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures

This study evaluated the mechanical properties and bone regeneration ability of 3D-printed pure hydroxyapatite (HA)/tricalcium phosphate (TCP) pure ceramic scaffolds with variable pore architectures. A digital light processing (DLP) 3D printer was used to construct block-type scaffolds containing on...

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Autores principales: Lim, Ho-Kyung, Hong, Seok-Jin, Byeon, Sun-Ju, Chung, Sung-Min, On, Sung-Woon, Yang, Byoung-Eun, Lee, Jong-Ho, Byun, Soo-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555666/
https://www.ncbi.nlm.nih.gov/pubmed/32971749
http://dx.doi.org/10.3390/ijms21186942
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author Lim, Ho-Kyung
Hong, Seok-Jin
Byeon, Sun-Ju
Chung, Sung-Min
On, Sung-Woon
Yang, Byoung-Eun
Lee, Jong-Ho
Byun, Soo-Hwan
author_facet Lim, Ho-Kyung
Hong, Seok-Jin
Byeon, Sun-Ju
Chung, Sung-Min
On, Sung-Woon
Yang, Byoung-Eun
Lee, Jong-Ho
Byun, Soo-Hwan
author_sort Lim, Ho-Kyung
collection PubMed
description This study evaluated the mechanical properties and bone regeneration ability of 3D-printed pure hydroxyapatite (HA)/tricalcium phosphate (TCP) pure ceramic scaffolds with variable pore architectures. A digital light processing (DLP) 3D printer was used to construct block-type scaffolds containing only HA and TCP after the polymer binder was completely removed by heat treatment. The compressive strength and porosity of the blocks with various structures were measured; scaffolds with different pore sizes were implanted in rabbit calvarial models. The animals were observed for eight weeks, and six animals were euthanized in the fourth and eighth weeks. Then, the specimens were evaluated using radiological and histological analyses. Larger scaffold pore sizes resulted in enhanced bone formation after four weeks (p < 0.05). However, in the eighth week, a correlation between pore size and bone formation was not observed (p > 0.05). The findings showed that various pore architectures of HA/TCP scaffolds can be achieved using DLP 3D printing, which can be a valuable tool for optimizing bone-scaffold properties for specific clinical treatments. As the pore size only influenced bone regeneration in the initial stage, further studies are required for pore-size optimization to balance the initial bone regeneration and mechanical strength of the scaffold.
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spelling pubmed-75556662020-10-19 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures Lim, Ho-Kyung Hong, Seok-Jin Byeon, Sun-Ju Chung, Sung-Min On, Sung-Woon Yang, Byoung-Eun Lee, Jong-Ho Byun, Soo-Hwan Int J Mol Sci Article This study evaluated the mechanical properties and bone regeneration ability of 3D-printed pure hydroxyapatite (HA)/tricalcium phosphate (TCP) pure ceramic scaffolds with variable pore architectures. A digital light processing (DLP) 3D printer was used to construct block-type scaffolds containing only HA and TCP after the polymer binder was completely removed by heat treatment. The compressive strength and porosity of the blocks with various structures were measured; scaffolds with different pore sizes were implanted in rabbit calvarial models. The animals were observed for eight weeks, and six animals were euthanized in the fourth and eighth weeks. Then, the specimens were evaluated using radiological and histological analyses. Larger scaffold pore sizes resulted in enhanced bone formation after four weeks (p < 0.05). However, in the eighth week, a correlation between pore size and bone formation was not observed (p > 0.05). The findings showed that various pore architectures of HA/TCP scaffolds can be achieved using DLP 3D printing, which can be a valuable tool for optimizing bone-scaffold properties for specific clinical treatments. As the pore size only influenced bone regeneration in the initial stage, further studies are required for pore-size optimization to balance the initial bone regeneration and mechanical strength of the scaffold. MDPI 2020-09-22 /pmc/articles/PMC7555666/ /pubmed/32971749 http://dx.doi.org/10.3390/ijms21186942 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lim, Ho-Kyung
Hong, Seok-Jin
Byeon, Sun-Ju
Chung, Sung-Min
On, Sung-Woon
Yang, Byoung-Eun
Lee, Jong-Ho
Byun, Soo-Hwan
3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures
title 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures
title_full 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures
title_fullStr 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures
title_full_unstemmed 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures
title_short 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures
title_sort 3d-printed ceramic bone scaffolds with variable pore architectures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555666/
https://www.ncbi.nlm.nih.gov/pubmed/32971749
http://dx.doi.org/10.3390/ijms21186942
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