Extracellular Alpha-Synuclein Promotes a Neuroinhibitory Secretory Phenotype in Astrocytes

Multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) are α-synucleinopathies that exhibit widespread astrogliosis as a component of the neuroinflammatory response. Munc18, a protein critical to vesicle exocytosis, was previously found to strongly mark morphologically activated astrocyte...

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Detalles Bibliográficos
Autores principales: Di Marco Vieira, Bruno, Radford, Rowan A. W., Hayashi, Junna, Eaton, Emma D., Greenaway, Ben, Jambas, Mark, Petcu, Eugen B., Chung, Roger S., Pountney, Dean L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555668/
https://www.ncbi.nlm.nih.gov/pubmed/32911644
http://dx.doi.org/10.3390/life10090183

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