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Biological Properties of a Citral-Enriched Fraction of Citrus limon Essential Oil
Lemon essential oil (LEO) is a well-known flavoring agent with versatile biological activities. In the present study, we have isolated and characterized four citral-enriched fractions of winter LEO. We reported that in murine and human macrophages the pre-treatment with a mix of these fractions (Cfr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555671/ https://www.ncbi.nlm.nih.gov/pubmed/32937843 http://dx.doi.org/10.3390/foods9091290 |
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author | Pucci, Marzia Raimondo, Stefania Zichittella, Chiara Tinnirello, Vincenza Corleone, Valeria Aiello, Gioacchino Moschetti, Marta Conigliaro, Alice Fontana, Simona Alessandro, Riccardo |
author_facet | Pucci, Marzia Raimondo, Stefania Zichittella, Chiara Tinnirello, Vincenza Corleone, Valeria Aiello, Gioacchino Moschetti, Marta Conigliaro, Alice Fontana, Simona Alessandro, Riccardo |
author_sort | Pucci, Marzia |
collection | PubMed |
description | Lemon essential oil (LEO) is a well-known flavoring agent with versatile biological activities. In the present study, we have isolated and characterized four citral-enriched fractions of winter LEO. We reported that in murine and human macrophages the pre-treatment with a mix of these fractions (Cfr-LEO) reduces the expression of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 induced by LPS. In addition, Cfr-LEO counteracts LPS-induced oxidative stress, as shown by the increase in the GSH/GSSG ratio in comparison to cells treated with LPS alone. Overall, the results reported here encourage the application of EO fractions, enriched in citral, in the nutraceutical industry, not only for its organoleptic properties but also for its protective action against inflammation and oxidative stress. |
format | Online Article Text |
id | pubmed-7555671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75556712020-10-19 Biological Properties of a Citral-Enriched Fraction of Citrus limon Essential Oil Pucci, Marzia Raimondo, Stefania Zichittella, Chiara Tinnirello, Vincenza Corleone, Valeria Aiello, Gioacchino Moschetti, Marta Conigliaro, Alice Fontana, Simona Alessandro, Riccardo Foods Article Lemon essential oil (LEO) is a well-known flavoring agent with versatile biological activities. In the present study, we have isolated and characterized four citral-enriched fractions of winter LEO. We reported that in murine and human macrophages the pre-treatment with a mix of these fractions (Cfr-LEO) reduces the expression of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 induced by LPS. In addition, Cfr-LEO counteracts LPS-induced oxidative stress, as shown by the increase in the GSH/GSSG ratio in comparison to cells treated with LPS alone. Overall, the results reported here encourage the application of EO fractions, enriched in citral, in the nutraceutical industry, not only for its organoleptic properties but also for its protective action against inflammation and oxidative stress. MDPI 2020-09-14 /pmc/articles/PMC7555671/ /pubmed/32937843 http://dx.doi.org/10.3390/foods9091290 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pucci, Marzia Raimondo, Stefania Zichittella, Chiara Tinnirello, Vincenza Corleone, Valeria Aiello, Gioacchino Moschetti, Marta Conigliaro, Alice Fontana, Simona Alessandro, Riccardo Biological Properties of a Citral-Enriched Fraction of Citrus limon Essential Oil |
title | Biological Properties of a Citral-Enriched Fraction of Citrus limon Essential Oil |
title_full | Biological Properties of a Citral-Enriched Fraction of Citrus limon Essential Oil |
title_fullStr | Biological Properties of a Citral-Enriched Fraction of Citrus limon Essential Oil |
title_full_unstemmed | Biological Properties of a Citral-Enriched Fraction of Citrus limon Essential Oil |
title_short | Biological Properties of a Citral-Enriched Fraction of Citrus limon Essential Oil |
title_sort | biological properties of a citral-enriched fraction of citrus limon essential oil |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555671/ https://www.ncbi.nlm.nih.gov/pubmed/32937843 http://dx.doi.org/10.3390/foods9091290 |
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