Cargando…
Potential Receptors for Targeted Imaging of Lymph Node Metastases in Penile Cancer
Imaging modalities using tumor-directed monoclonal antibodies may be of value to improve the pre- and intraoperative detection and resection of lymph node (LN) metastatic disease in penile squamous cell carcinoma (PSCC). We investigated the expression of prostate-specific membrane antigen (PSMA), va...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555672/ https://www.ncbi.nlm.nih.gov/pubmed/32942549 http://dx.doi.org/10.3390/diagnostics10090694 |
_version_ | 1783594062040793088 |
---|---|
author | van der Fels, Christa A. M. Palthe, Selma Buikema, Henk van den Heuvel, Marius C. Leliveld, Annemarie de Jong, Igle Jan |
author_facet | van der Fels, Christa A. M. Palthe, Selma Buikema, Henk van den Heuvel, Marius C. Leliveld, Annemarie de Jong, Igle Jan |
author_sort | van der Fels, Christa A. M. |
collection | PubMed |
description | Imaging modalities using tumor-directed monoclonal antibodies may be of value to improve the pre- and intraoperative detection and resection of lymph node (LN) metastatic disease in penile squamous cell carcinoma (PSCC). We investigated the expression of prostate-specific membrane antigen (PSMA), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR) and epithelial cell adhesion molecule (EpCAM) to analyze their potency for diagnostic applications. Antigen expression was determined in primary tumors and LNs with and without metastases of 22 patients with PSCC. The total immunostaining score (TIS, 0–12) was determined as the product of a proportion score (PS, 0–4) and an intensity score (IS, 0–3). EGFR and VEGF expression were high in primary tumor (median TIS 8) and LN metastases (median TIS 6 and 8, respectively). No EGFR expression was seen in LNs without metastases. However, LNs without metastases did show VEGF expression (median TIS 6). No EpCAM or PSMA expression was seen in PSCC. This study shows that VEGF and EGFR expression is moderate to high in LN metastases of PSCC. Both VEGF and EGFR warrant further clinical evaluation to determine their value as a target for pre- and intraoperative imaging modalities in the detection of LN metastases in PSCC. |
format | Online Article Text |
id | pubmed-7555672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75556722020-10-19 Potential Receptors for Targeted Imaging of Lymph Node Metastases in Penile Cancer van der Fels, Christa A. M. Palthe, Selma Buikema, Henk van den Heuvel, Marius C. Leliveld, Annemarie de Jong, Igle Jan Diagnostics (Basel) Article Imaging modalities using tumor-directed monoclonal antibodies may be of value to improve the pre- and intraoperative detection and resection of lymph node (LN) metastatic disease in penile squamous cell carcinoma (PSCC). We investigated the expression of prostate-specific membrane antigen (PSMA), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR) and epithelial cell adhesion molecule (EpCAM) to analyze their potency for diagnostic applications. Antigen expression was determined in primary tumors and LNs with and without metastases of 22 patients with PSCC. The total immunostaining score (TIS, 0–12) was determined as the product of a proportion score (PS, 0–4) and an intensity score (IS, 0–3). EGFR and VEGF expression were high in primary tumor (median TIS 8) and LN metastases (median TIS 6 and 8, respectively). No EGFR expression was seen in LNs without metastases. However, LNs without metastases did show VEGF expression (median TIS 6). No EpCAM or PSMA expression was seen in PSCC. This study shows that VEGF and EGFR expression is moderate to high in LN metastases of PSCC. Both VEGF and EGFR warrant further clinical evaluation to determine their value as a target for pre- and intraoperative imaging modalities in the detection of LN metastases in PSCC. MDPI 2020-09-15 /pmc/articles/PMC7555672/ /pubmed/32942549 http://dx.doi.org/10.3390/diagnostics10090694 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article van der Fels, Christa A. M. Palthe, Selma Buikema, Henk van den Heuvel, Marius C. Leliveld, Annemarie de Jong, Igle Jan Potential Receptors for Targeted Imaging of Lymph Node Metastases in Penile Cancer |
title | Potential Receptors for Targeted Imaging of Lymph Node Metastases in Penile Cancer |
title_full | Potential Receptors for Targeted Imaging of Lymph Node Metastases in Penile Cancer |
title_fullStr | Potential Receptors for Targeted Imaging of Lymph Node Metastases in Penile Cancer |
title_full_unstemmed | Potential Receptors for Targeted Imaging of Lymph Node Metastases in Penile Cancer |
title_short | Potential Receptors for Targeted Imaging of Lymph Node Metastases in Penile Cancer |
title_sort | potential receptors for targeted imaging of lymph node metastases in penile cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555672/ https://www.ncbi.nlm.nih.gov/pubmed/32942549 http://dx.doi.org/10.3390/diagnostics10090694 |
work_keys_str_mv | AT vanderfelschristaam potentialreceptorsfortargetedimagingoflymphnodemetastasesinpenilecancer AT paltheselma potentialreceptorsfortargetedimagingoflymphnodemetastasesinpenilecancer AT buikemahenk potentialreceptorsfortargetedimagingoflymphnodemetastasesinpenilecancer AT vandenheuvelmariusc potentialreceptorsfortargetedimagingoflymphnodemetastasesinpenilecancer AT leliveldannemarie potentialreceptorsfortargetedimagingoflymphnodemetastasesinpenilecancer AT dejongiglejan potentialreceptorsfortargetedimagingoflymphnodemetastasesinpenilecancer |