Cargando…

Novel 1,3,4-oxadiazole Targets STAT3 Signaling to Induce Antitumor Effect in Lung Cancer

Lung cancer is the leading type of malignancy in terms of occurrence and mortality in the global context. STAT3 is an oncogenic transcription factor that is persistently activated in many types of human malignancies, including lung cancer. In the present report, new oxadiazole conjugated indazoles w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Malojirao, Vikas H., Girimanchanaika, Swamy S., Shanmugam, Muthu K., Sherapura, Ankith, Dukanya, Metri, Prashant K., Vigneshwaran, Vellingiri, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Rangappa, Shobith, Mohan, Chakrabhavi Dhananjaya, Basappa, Prabhakar, Bettadathunga T., Rangappa, Kanchugarakoppal S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555749/ https://www.ncbi.nlm.nih.gov/pubmed/32967366 http://dx.doi.org/10.3390/biomedicines8090368

Ejemplares similares

Anti-proliferative activity and characterization data on oxadiazole derivatives
por: Dukanya, et al.
Publicado: (2020)

Novel 1,3,4-Oxadiazole Induces Anticancer Activity by Targeting NF-κB in Hepatocellular Carcinoma Cells
por: Mohan, Chakrabhavi Dhananjaya, et al.
Publicado: (2018)

Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase
por: Vishwanath, Divakar, et al.
Publicado: (2022)

Identification of a novel 1,2 oxazine that can induce apoptosis by targeting NF-κB in hepatocellular carcinoma cells
por: Somu, Chaithanya, et al.
Publicado: (2020)

N-Substituted Pyrido-1,4-Oxazin-3-Ones Induce Apoptosis of Hepatocellular Carcinoma Cells by Targeting NF-κB Signaling Pathway
por: Mohan, Chakrabhavi Dhananjaya, et al.
Publicado: (2018)

New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis
por: Barash, Uri, et al.
Publicado: (2021)

Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway
por: Mohan, Chakrabhavi Dhananjaya, et al.
Publicado: (2016)

The IκB Kinase Inhibitor ACHP Targets the STAT3 Signaling Pathway in Human Non-Small Cell Lung Carcinoma Cells
por: Lee, Jong Hyun, et al.
Publicado: (2019)

Investigation of NPB Analogs That Target Phosphorylation of BAD-Ser99 in Human Mammary Carcinoma Cells
por: Girimanchanaika, Swamy Savvemala, et al.
Publicado: (2021)

Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo
por: Nirvanappa, Anilkumar C., et al.
Publicado: (2016)

Correction: Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo
por: Nirvanappa, Anilkumar C., et al.
Publicado: (2017)

Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma
por: Lee, Jong Hyun, et al.
Publicado: (2019)

A One Pot Synthesis of Novel Bioactive Tri-Substitute-Condensed-Imidazopyridines that Targets Snake Venom Phospholipase A(2)
por: Anilkumar, Nirvanappa C., et al.
Publicado: (2015)

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity
por: Baburajeev, C. P., et al.
Publicado: (2017)

3-Formylchromone Counteracts STAT3 Signaling Pathway by Elevating SHP-2 Expression in Hepatocellular Carcinoma
por: Mohan, Chakrabhavi Dhananjaya, et al.
Publicado: (2021)

Development of Novel Triazolo-Thiadiazoles from Heterogeneous “Green” Catalysis as Protein Tyrosine Phosphatase 1B Inhibitors
por: Baburajeev, C. P., et al.
Publicado: (2015)

Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds
por: Mohan, Chakrabhavi Dhananjaya, et al.
Publicado: (2019)

Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma
por: Lee, Jong Hyun, et al.
Publicado: (2020)

Euphorbiasteroid Abrogates EGFR and Wnt/β-Catenin Signaling in Non-Small-Cell Lung Cancer Cells to Impart Anticancer Activity
por: Kim, Na Young, et al.
Publicado: (2022)

A Nano-MgO and Ionic Liquid-Catalyzed ‘Green’ Synthesis Protocol for the Development of Adamantyl-Imidazolo-Thiadiazoles as Anti-Tuberculosis Agents Targeting Sterol 14α-Demethylase (CYP51)
por: Anusha, Sebastian, et al.
Publicado: (2015)

Phytochemicals as Invaluable Sources of Potent Antimicrobial Agents to Combat Antibiotic Resistance
por: Jadimurthy, Ragi, et al.
Publicado: (2023)

Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway
por: Arora, Loukik, et al.
Publicado: (2021)

Synthesis and Characterization of Novel 2-Amino-Chromene-Nitriles that Target Bcl-2 in Acute Myeloid Leukemia Cell Lines
por: Keerthy, Hosadurga K., et al.
Publicado: (2014)

Development of 1-(4-(Substituted)piperazin-1-yl)-2-((2-((4-methoxybenzyl)thio)pyrimidin-4-yl)oxy)ethanones That Target Poly (ADP-Ribose) Polymerase in Human Breast Cancer Cells
por: Deveshegowda, Suresha N., et al.
Publicado: (2022)

Escaping mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds
por: Jadimurthy, Ragi, et al.
Publicado: (2022)

Microwave assisted one-pot access to pyrazolo quinolinone and tetrahydroisoxazolo quinolinone derivatives via T3P®-DMSO catalysed tandem oxidative–condensation reaction
por: Gowda, Darshini, et al.
Publicado: (2023)

Novel Adamantanyl-Based Thiadiazolyl Pyrazoles Targeting EGFR in Triple-Negative Breast Cancer
por: Sebastian, Anusha, et al.
Publicado: (2016)

Procaine Abrogates the Epithelial-Mesenchymal Transition Process through Modulating c-Met Phosphorylation in Hepatocellular Carcinoma
por: Yang, Min Hee, et al.
Publicado: (2022)

Metabolite Profiling of Alangium salviifolium Bark Using Advanced LC/MS and GC/Q-TOFTechnology
por: Siddaiah, Chandranayaka, et al.
Publicado: (2020)

A New Ibuprofen Derivative Inhibits Platelet Aggregation and ROS Mediated Platelet Apoptosis
por: Rakesh, Kodagahalli S., et al.
Publicado: (2014)

Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4
por: Bhuvanalakshmi, G., et al.
Publicado: (2017)

Green Synthesis of Silver Nanoparticles by Cytobacillus firmus Isolated from the Stem Bark of Terminalia arjuna and Their Antimicrobial Activity
por: Sudarsan, Sujesh, et al.
Publicado: (2021)

Novel Benzoxazine-Based Aglycones Block Glucose Uptake In Vivo by Inhibiting Glycosidases
por: Bharathkumar, Hanumantharayappa, et al.
Publicado: (2014)

Inhibitory effect of C. zeylanicum, C. longa, O. basilicum, Z. officinale, and C. martini essential oils on growth and ochratoxin A content of A. ochraceous and P. verrucosum in maize grains
por: Kalagatur, Naveen Kumar, et al.
Publicado: (2020)

Novel 1,2,5-Trisubstituted Benzimidazoles Potentiate Apoptosis by Mitochondrial Dysfunction in Panel of Cancer Cells
por: Swathantraiah, Jagadeesha Gullahalli, et al.
Publicado: (2022)

2,3,5,6-Tetramethylpyrazine Targets Epithelial-Mesenchymal Transition by Abrogating Manganese Superoxide Dismutase Expression and TGFβ-Driven Signaling Cascades in Colon Cancer Cells
por: Jung, Young Yun, et al.
Publicado: (2022)

N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methoxybenzamide
por: Nanjunda Swamy, S., et al.
Publicado: (2010)

Novel Apigenin Based Small Molecule that Targets Snake Venom Metalloproteases
por: Srinivasa, Venkatachalaiah, et al.
Publicado: (2014)

Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives
por: Glomb, Teresa, et al.
Publicado: (2021)

Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives
por: Sadashiva, Maralinganadoddi Panchegowda, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_u7bb0l0vr5kb1aga9f00p74oan