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Modulation of functional network properties in major depressive disorder following electroconvulsive therapy (ECT): a resting-state EEG analysis

Electroconvulsive therapy (ECT) is a highly effective neuromodulatory intervention for treatment-resistant major depressive disorder (MDD). Presently, however, understanding of its neurophysiological effects remains incomplete. In the present study, we utilised resting-state electroencephalography (...

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Autores principales: Hill, Aron T., Hadas, Itay, Zomorrodi, Reza, Voineskos, Daphne, Farzan, Faranak, Fitzgerald, Paul B., Blumberger, Daniel M., Daskalakis, Zafiris J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555809/
https://www.ncbi.nlm.nih.gov/pubmed/33051528
http://dx.doi.org/10.1038/s41598-020-74103-y
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author Hill, Aron T.
Hadas, Itay
Zomorrodi, Reza
Voineskos, Daphne
Farzan, Faranak
Fitzgerald, Paul B.
Blumberger, Daniel M.
Daskalakis, Zafiris J.
author_facet Hill, Aron T.
Hadas, Itay
Zomorrodi, Reza
Voineskos, Daphne
Farzan, Faranak
Fitzgerald, Paul B.
Blumberger, Daniel M.
Daskalakis, Zafiris J.
author_sort Hill, Aron T.
collection PubMed
description Electroconvulsive therapy (ECT) is a highly effective neuromodulatory intervention for treatment-resistant major depressive disorder (MDD). Presently, however, understanding of its neurophysiological effects remains incomplete. In the present study, we utilised resting-state electroencephalography (RS-EEG) to explore changes in functional connectivity, network topology, and spectral power elicited by an acute open-label course of ECT in a cohort of 23 patients with treatment-resistant MDD. RS-EEG was recorded prior to commencement of ECT and again within 48 h following each patient’s final treatment session. Our results show that ECT was able to enhance connectivity within lower (delta and theta) frequency bands across subnetworks largely confined to fronto-central channels, while, conversely, more widespread subnetworks of reduced connectivity emerged within faster (alpha and beta) bands following treatment. Graph-based topological analyses revealed changes in measures of functional segregation (clustering coefficient), integration (characteristic path length), and small-world architecture following ECT. Finally, post-treatment enhancement of delta and theta spectral power was observed, which showed a positive association with the number of ECT sessions received. Overall, our findings indicate that RS-EEG can provide a sensitive measure of dynamic neural activity following ECT and highlight network-based analyses as a promising avenue for furthering mechanistic understanding of the effects of convulsive therapies.
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spelling pubmed-75558092020-10-14 Modulation of functional network properties in major depressive disorder following electroconvulsive therapy (ECT): a resting-state EEG analysis Hill, Aron T. Hadas, Itay Zomorrodi, Reza Voineskos, Daphne Farzan, Faranak Fitzgerald, Paul B. Blumberger, Daniel M. Daskalakis, Zafiris J. Sci Rep Article Electroconvulsive therapy (ECT) is a highly effective neuromodulatory intervention for treatment-resistant major depressive disorder (MDD). Presently, however, understanding of its neurophysiological effects remains incomplete. In the present study, we utilised resting-state electroencephalography (RS-EEG) to explore changes in functional connectivity, network topology, and spectral power elicited by an acute open-label course of ECT in a cohort of 23 patients with treatment-resistant MDD. RS-EEG was recorded prior to commencement of ECT and again within 48 h following each patient’s final treatment session. Our results show that ECT was able to enhance connectivity within lower (delta and theta) frequency bands across subnetworks largely confined to fronto-central channels, while, conversely, more widespread subnetworks of reduced connectivity emerged within faster (alpha and beta) bands following treatment. Graph-based topological analyses revealed changes in measures of functional segregation (clustering coefficient), integration (characteristic path length), and small-world architecture following ECT. Finally, post-treatment enhancement of delta and theta spectral power was observed, which showed a positive association with the number of ECT sessions received. Overall, our findings indicate that RS-EEG can provide a sensitive measure of dynamic neural activity following ECT and highlight network-based analyses as a promising avenue for furthering mechanistic understanding of the effects of convulsive therapies. Nature Publishing Group UK 2020-10-13 /pmc/articles/PMC7555809/ /pubmed/33051528 http://dx.doi.org/10.1038/s41598-020-74103-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hill, Aron T.
Hadas, Itay
Zomorrodi, Reza
Voineskos, Daphne
Farzan, Faranak
Fitzgerald, Paul B.
Blumberger, Daniel M.
Daskalakis, Zafiris J.
Modulation of functional network properties in major depressive disorder following electroconvulsive therapy (ECT): a resting-state EEG analysis
title Modulation of functional network properties in major depressive disorder following electroconvulsive therapy (ECT): a resting-state EEG analysis
title_full Modulation of functional network properties in major depressive disorder following electroconvulsive therapy (ECT): a resting-state EEG analysis
title_fullStr Modulation of functional network properties in major depressive disorder following electroconvulsive therapy (ECT): a resting-state EEG analysis
title_full_unstemmed Modulation of functional network properties in major depressive disorder following electroconvulsive therapy (ECT): a resting-state EEG analysis
title_short Modulation of functional network properties in major depressive disorder following electroconvulsive therapy (ECT): a resting-state EEG analysis
title_sort modulation of functional network properties in major depressive disorder following electroconvulsive therapy (ect): a resting-state eeg analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555809/
https://www.ncbi.nlm.nih.gov/pubmed/33051528
http://dx.doi.org/10.1038/s41598-020-74103-y
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