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Formation and Recognition of UV-Induced DNA Damage within Genome Complexity

Ultraviolet (UV) light is a natural genotoxic agent leading to the formation of photolesions endangering the genomic integrity and thereby the survival of living organisms. To prevent the mutagenetic effect of UV, several specific DNA repair mechanisms are mobilized to accurately maintain genome int...

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Detalles Bibliográficos
Autores principales: Johann to Berens, Philippe, Molinier, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555853/
https://www.ncbi.nlm.nih.gov/pubmed/32932704
http://dx.doi.org/10.3390/ijms21186689
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author Johann to Berens, Philippe
Molinier, Jean
author_facet Johann to Berens, Philippe
Molinier, Jean
author_sort Johann to Berens, Philippe
collection PubMed
description Ultraviolet (UV) light is a natural genotoxic agent leading to the formation of photolesions endangering the genomic integrity and thereby the survival of living organisms. To prevent the mutagenetic effect of UV, several specific DNA repair mechanisms are mobilized to accurately maintain genome integrity at photodamaged sites within the complexity of genome structures. However, a fundamental gap remains to be filled in the identification and characterization of factors at the nexus of UV-induced DNA damage, DNA repair, and epigenetics. This review brings together the impact of the epigenomic context on the susceptibility of genomic regions to form photodamage and focuses on the mechanisms of photolesions recognition through the different DNA repair pathways.
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spelling pubmed-75558532020-10-19 Formation and Recognition of UV-Induced DNA Damage within Genome Complexity Johann to Berens, Philippe Molinier, Jean Int J Mol Sci Review Ultraviolet (UV) light is a natural genotoxic agent leading to the formation of photolesions endangering the genomic integrity and thereby the survival of living organisms. To prevent the mutagenetic effect of UV, several specific DNA repair mechanisms are mobilized to accurately maintain genome integrity at photodamaged sites within the complexity of genome structures. However, a fundamental gap remains to be filled in the identification and characterization of factors at the nexus of UV-induced DNA damage, DNA repair, and epigenetics. This review brings together the impact of the epigenomic context on the susceptibility of genomic regions to form photodamage and focuses on the mechanisms of photolesions recognition through the different DNA repair pathways. MDPI 2020-09-12 /pmc/articles/PMC7555853/ /pubmed/32932704 http://dx.doi.org/10.3390/ijms21186689 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Johann to Berens, Philippe
Molinier, Jean
Formation and Recognition of UV-Induced DNA Damage within Genome Complexity
title Formation and Recognition of UV-Induced DNA Damage within Genome Complexity
title_full Formation and Recognition of UV-Induced DNA Damage within Genome Complexity
title_fullStr Formation and Recognition of UV-Induced DNA Damage within Genome Complexity
title_full_unstemmed Formation and Recognition of UV-Induced DNA Damage within Genome Complexity
title_short Formation and Recognition of UV-Induced DNA Damage within Genome Complexity
title_sort formation and recognition of uv-induced dna damage within genome complexity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555853/
https://www.ncbi.nlm.nih.gov/pubmed/32932704
http://dx.doi.org/10.3390/ijms21186689
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