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Formation and Recognition of UV-Induced DNA Damage within Genome Complexity
Ultraviolet (UV) light is a natural genotoxic agent leading to the formation of photolesions endangering the genomic integrity and thereby the survival of living organisms. To prevent the mutagenetic effect of UV, several specific DNA repair mechanisms are mobilized to accurately maintain genome int...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555853/ https://www.ncbi.nlm.nih.gov/pubmed/32932704 http://dx.doi.org/10.3390/ijms21186689 |
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author | Johann to Berens, Philippe Molinier, Jean |
author_facet | Johann to Berens, Philippe Molinier, Jean |
author_sort | Johann to Berens, Philippe |
collection | PubMed |
description | Ultraviolet (UV) light is a natural genotoxic agent leading to the formation of photolesions endangering the genomic integrity and thereby the survival of living organisms. To prevent the mutagenetic effect of UV, several specific DNA repair mechanisms are mobilized to accurately maintain genome integrity at photodamaged sites within the complexity of genome structures. However, a fundamental gap remains to be filled in the identification and characterization of factors at the nexus of UV-induced DNA damage, DNA repair, and epigenetics. This review brings together the impact of the epigenomic context on the susceptibility of genomic regions to form photodamage and focuses on the mechanisms of photolesions recognition through the different DNA repair pathways. |
format | Online Article Text |
id | pubmed-7555853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75558532020-10-19 Formation and Recognition of UV-Induced DNA Damage within Genome Complexity Johann to Berens, Philippe Molinier, Jean Int J Mol Sci Review Ultraviolet (UV) light is a natural genotoxic agent leading to the formation of photolesions endangering the genomic integrity and thereby the survival of living organisms. To prevent the mutagenetic effect of UV, several specific DNA repair mechanisms are mobilized to accurately maintain genome integrity at photodamaged sites within the complexity of genome structures. However, a fundamental gap remains to be filled in the identification and characterization of factors at the nexus of UV-induced DNA damage, DNA repair, and epigenetics. This review brings together the impact of the epigenomic context on the susceptibility of genomic regions to form photodamage and focuses on the mechanisms of photolesions recognition through the different DNA repair pathways. MDPI 2020-09-12 /pmc/articles/PMC7555853/ /pubmed/32932704 http://dx.doi.org/10.3390/ijms21186689 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Johann to Berens, Philippe Molinier, Jean Formation and Recognition of UV-Induced DNA Damage within Genome Complexity |
title | Formation and Recognition of UV-Induced DNA Damage within Genome Complexity |
title_full | Formation and Recognition of UV-Induced DNA Damage within Genome Complexity |
title_fullStr | Formation and Recognition of UV-Induced DNA Damage within Genome Complexity |
title_full_unstemmed | Formation and Recognition of UV-Induced DNA Damage within Genome Complexity |
title_short | Formation and Recognition of UV-Induced DNA Damage within Genome Complexity |
title_sort | formation and recognition of uv-induced dna damage within genome complexity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555853/ https://www.ncbi.nlm.nih.gov/pubmed/32932704 http://dx.doi.org/10.3390/ijms21186689 |
work_keys_str_mv | AT johanntoberensphilippe formationandrecognitionofuvinduceddnadamagewithingenomecomplexity AT molinierjean formationandrecognitionofuvinduceddnadamagewithingenomecomplexity |