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Diabetes Mellitus, Mitochondrial Dysfunction and Ca(2+)-Dependent Permeability Transition Pore

Diabetes mellitus is one of the most common metabolic diseases in the developed world, and is associated either with the impaired secretion of insulin or with the resistance of cells to the actions of this hormone (type I and type II diabetes, respectively). In both cases, a common pathological chan...

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Autores principales: Belosludtsev, Konstantin N., Belosludtseva, Natalia V., Dubinin, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555889/
https://www.ncbi.nlm.nih.gov/pubmed/32911736
http://dx.doi.org/10.3390/ijms21186559
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author Belosludtsev, Konstantin N.
Belosludtseva, Natalia V.
Dubinin, Mikhail V.
author_facet Belosludtsev, Konstantin N.
Belosludtseva, Natalia V.
Dubinin, Mikhail V.
author_sort Belosludtsev, Konstantin N.
collection PubMed
description Diabetes mellitus is one of the most common metabolic diseases in the developed world, and is associated either with the impaired secretion of insulin or with the resistance of cells to the actions of this hormone (type I and type II diabetes, respectively). In both cases, a common pathological change is an increase in blood glucose—hyperglycemia, which eventually can lead to serious damage to the organs and tissues of the organism. Mitochondria are one of the main targets of diabetes at the intracellular level. This review is dedicated to the analysis of recent data regarding the role of mitochondrial dysfunction in the development of diabetes mellitus. Specific areas of focus include the involvement of mitochondrial calcium transport systems and a pathophysiological phenomenon called the permeability transition pore in the pathogenesis of diabetes mellitus. The important contribution of these systems and their potential relevance as therapeutic targets in the pathology are discussed.
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spelling pubmed-75558892020-10-19 Diabetes Mellitus, Mitochondrial Dysfunction and Ca(2+)-Dependent Permeability Transition Pore Belosludtsev, Konstantin N. Belosludtseva, Natalia V. Dubinin, Mikhail V. Int J Mol Sci Review Diabetes mellitus is one of the most common metabolic diseases in the developed world, and is associated either with the impaired secretion of insulin or with the resistance of cells to the actions of this hormone (type I and type II diabetes, respectively). In both cases, a common pathological change is an increase in blood glucose—hyperglycemia, which eventually can lead to serious damage to the organs and tissues of the organism. Mitochondria are one of the main targets of diabetes at the intracellular level. This review is dedicated to the analysis of recent data regarding the role of mitochondrial dysfunction in the development of diabetes mellitus. Specific areas of focus include the involvement of mitochondrial calcium transport systems and a pathophysiological phenomenon called the permeability transition pore in the pathogenesis of diabetes mellitus. The important contribution of these systems and their potential relevance as therapeutic targets in the pathology are discussed. MDPI 2020-09-08 /pmc/articles/PMC7555889/ /pubmed/32911736 http://dx.doi.org/10.3390/ijms21186559 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Belosludtsev, Konstantin N.
Belosludtseva, Natalia V.
Dubinin, Mikhail V.
Diabetes Mellitus, Mitochondrial Dysfunction and Ca(2+)-Dependent Permeability Transition Pore
title Diabetes Mellitus, Mitochondrial Dysfunction and Ca(2+)-Dependent Permeability Transition Pore
title_full Diabetes Mellitus, Mitochondrial Dysfunction and Ca(2+)-Dependent Permeability Transition Pore
title_fullStr Diabetes Mellitus, Mitochondrial Dysfunction and Ca(2+)-Dependent Permeability Transition Pore
title_full_unstemmed Diabetes Mellitus, Mitochondrial Dysfunction and Ca(2+)-Dependent Permeability Transition Pore
title_short Diabetes Mellitus, Mitochondrial Dysfunction and Ca(2+)-Dependent Permeability Transition Pore
title_sort diabetes mellitus, mitochondrial dysfunction and ca(2+)-dependent permeability transition pore
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555889/
https://www.ncbi.nlm.nih.gov/pubmed/32911736
http://dx.doi.org/10.3390/ijms21186559
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