Lack of tocilizumab effect on mortality in COVID19 patients

Off-label tocilizumab use in COVID-19 patients reflects concern for cytokine release syndrome. Comparison of matched COVID-19 pneumonia patients found elevated IL-6 levels correlated with mortality that did not change with tocilizumab administration. Correlating mortality with increased IL-6 doesn’t...

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Autores principales: Holt, Gregory E., Batra, Mayank, Murthi, Mukunthan, Kambali, Shweta, Santos, Kayo, Bastidas, Maria Virginia Perez, Asif, Huda, Haddadi, Sara, Arias, Sixto, Mirsaeidi, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555891/
https://www.ncbi.nlm.nih.gov/pubmed/33051534
http://dx.doi.org/10.1038/s41598-020-74328-x
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author Holt, Gregory E.
Batra, Mayank
Murthi, Mukunthan
Kambali, Shweta
Santos, Kayo
Bastidas, Maria Virginia Perez
Asif, Huda
Haddadi, Sara
Arias, Sixto
Mirsaeidi, Mehdi
author_facet Holt, Gregory E.
Batra, Mayank
Murthi, Mukunthan
Kambali, Shweta
Santos, Kayo
Bastidas, Maria Virginia Perez
Asif, Huda
Haddadi, Sara
Arias, Sixto
Mirsaeidi, Mehdi
author_sort Holt, Gregory E.
collection PubMed
description Off-label tocilizumab use in COVID-19 patients reflects concern for cytokine release syndrome. Comparison of matched COVID-19 pneumonia patients found elevated IL-6 levels correlated with mortality that did not change with tocilizumab administration. Correlating mortality with increased IL-6 doesn’t imply causality however lack of improvement by tocilizumab requires further clinical trial alterations.
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spelling pubmed-75558912020-10-14 Lack of tocilizumab effect on mortality in COVID19 patients Holt, Gregory E. Batra, Mayank Murthi, Mukunthan Kambali, Shweta Santos, Kayo Bastidas, Maria Virginia Perez Asif, Huda Haddadi, Sara Arias, Sixto Mirsaeidi, Mehdi Sci Rep Article Off-label tocilizumab use in COVID-19 patients reflects concern for cytokine release syndrome. Comparison of matched COVID-19 pneumonia patients found elevated IL-6 levels correlated with mortality that did not change with tocilizumab administration. Correlating mortality with increased IL-6 doesn’t imply causality however lack of improvement by tocilizumab requires further clinical trial alterations. Nature Publishing Group UK 2020-10-13 /pmc/articles/PMC7555891/ /pubmed/33051534 http://dx.doi.org/10.1038/s41598-020-74328-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Holt, Gregory E.
Batra, Mayank
Murthi, Mukunthan
Kambali, Shweta
Santos, Kayo
Bastidas, Maria Virginia Perez
Asif, Huda
Haddadi, Sara
Arias, Sixto
Mirsaeidi, Mehdi
Lack of tocilizumab effect on mortality in COVID19 patients
title Lack of tocilizumab effect on mortality in COVID19 patients
title_full Lack of tocilizumab effect on mortality in COVID19 patients
title_fullStr Lack of tocilizumab effect on mortality in COVID19 patients
title_full_unstemmed Lack of tocilizumab effect on mortality in COVID19 patients
title_short Lack of tocilizumab effect on mortality in COVID19 patients
title_sort lack of tocilizumab effect on mortality in covid19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555891/
https://www.ncbi.nlm.nih.gov/pubmed/33051534
http://dx.doi.org/10.1038/s41598-020-74328-x
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