Recent Advances in Cell-Based Therapies for Ischemic Stroke

Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading causes of death and disability. Stem cell-based therapy is actively being investigated as a new potential treatment for certain neurological disorders, including stroke. Various types of cells, including b...

Descripción completa

Detalles Bibliográficos
Autores principales: Suda, Satoshi, Nito, Chikako, Yokobori, Shoji, Sakamoto, Yuki, Nakajima, Masataka, Sowa, Kota, Obinata, Hirofumi, Sasaki, Kazuma, Savitz, Sean I., Kimura, Kazumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555943/
https://www.ncbi.nlm.nih.gov/pubmed/32937754
http://dx.doi.org/10.3390/ijms21186718
_version_ 1783594124831621120
author Suda, Satoshi
Nito, Chikako
Yokobori, Shoji
Sakamoto, Yuki
Nakajima, Masataka
Sowa, Kota
Obinata, Hirofumi
Sasaki, Kazuma
Savitz, Sean I.
Kimura, Kazumi
author_facet Suda, Satoshi
Nito, Chikako
Yokobori, Shoji
Sakamoto, Yuki
Nakajima, Masataka
Sowa, Kota
Obinata, Hirofumi
Sasaki, Kazuma
Savitz, Sean I.
Kimura, Kazumi
author_sort Suda, Satoshi
collection PubMed
description Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading causes of death and disability. Stem cell-based therapy is actively being investigated as a new potential treatment for certain neurological disorders, including stroke. Various types of cells, including bone marrow mononuclear cells, bone marrow mesenchymal stem cells, dental pulp stem cells, neural stem cells, inducible pluripotent stem cells, and genetically modified stem cells have been found to improve neurological outcomes in animal models of stroke, and there are some ongoing clinical trials assessing their efficacy in humans. In this review, we aim to summarize the recent advances in cell-based therapies to treat stroke.
format Online
Article
Text
id pubmed-7555943
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75559432020-10-19 Recent Advances in Cell-Based Therapies for Ischemic Stroke Suda, Satoshi Nito, Chikako Yokobori, Shoji Sakamoto, Yuki Nakajima, Masataka Sowa, Kota Obinata, Hirofumi Sasaki, Kazuma Savitz, Sean I. Kimura, Kazumi Int J Mol Sci Review Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading causes of death and disability. Stem cell-based therapy is actively being investigated as a new potential treatment for certain neurological disorders, including stroke. Various types of cells, including bone marrow mononuclear cells, bone marrow mesenchymal stem cells, dental pulp stem cells, neural stem cells, inducible pluripotent stem cells, and genetically modified stem cells have been found to improve neurological outcomes in animal models of stroke, and there are some ongoing clinical trials assessing their efficacy in humans. In this review, we aim to summarize the recent advances in cell-based therapies to treat stroke. MDPI 2020-09-14 /pmc/articles/PMC7555943/ /pubmed/32937754 http://dx.doi.org/10.3390/ijms21186718 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Suda, Satoshi
Nito, Chikako
Yokobori, Shoji
Sakamoto, Yuki
Nakajima, Masataka
Sowa, Kota
Obinata, Hirofumi
Sasaki, Kazuma
Savitz, Sean I.
Kimura, Kazumi
Recent Advances in Cell-Based Therapies for Ischemic Stroke
title Recent Advances in Cell-Based Therapies for Ischemic Stroke
title_full Recent Advances in Cell-Based Therapies for Ischemic Stroke
title_fullStr Recent Advances in Cell-Based Therapies for Ischemic Stroke
title_full_unstemmed Recent Advances in Cell-Based Therapies for Ischemic Stroke
title_short Recent Advances in Cell-Based Therapies for Ischemic Stroke
title_sort recent advances in cell-based therapies for ischemic stroke
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555943/
https://www.ncbi.nlm.nih.gov/pubmed/32937754
http://dx.doi.org/10.3390/ijms21186718
work_keys_str_mv AT sudasatoshi recentadvancesincellbasedtherapiesforischemicstroke
AT nitochikako recentadvancesincellbasedtherapiesforischemicstroke
AT yokoborishoji recentadvancesincellbasedtherapiesforischemicstroke
AT sakamotoyuki recentadvancesincellbasedtherapiesforischemicstroke
AT nakajimamasataka recentadvancesincellbasedtherapiesforischemicstroke
AT sowakota recentadvancesincellbasedtherapiesforischemicstroke
AT obinatahirofumi recentadvancesincellbasedtherapiesforischemicstroke
AT sasakikazuma recentadvancesincellbasedtherapiesforischemicstroke
AT savitzseani recentadvancesincellbasedtherapiesforischemicstroke
AT kimurakazumi recentadvancesincellbasedtherapiesforischemicstroke

Ejemplares similares