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Extracellular Vesicles: New Endogenous Shuttles for miRNAs in Cancer Diagnosis and Therapy?

Extracellular Vesicles (EVs) represent a heterogeneous population of membranous cell-derived structures, including cargo-oriented exosomes and microvesicles. EVs are functionally associated with intercellular communication and play an essential role in multiple physiopathological conditions. Sheddin...

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Autores principales: Martellucci, Stefano, Orefice, Nicola Salvatore, Angelucci, Adriano, Luce, Amalia, Caraglia, Michele, Zappavigna, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555972/
https://www.ncbi.nlm.nih.gov/pubmed/32899898
http://dx.doi.org/10.3390/ijms21186486
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author Martellucci, Stefano
Orefice, Nicola Salvatore
Angelucci, Adriano
Luce, Amalia
Caraglia, Michele
Zappavigna, Silvia
author_facet Martellucci, Stefano
Orefice, Nicola Salvatore
Angelucci, Adriano
Luce, Amalia
Caraglia, Michele
Zappavigna, Silvia
author_sort Martellucci, Stefano
collection PubMed
description Extracellular Vesicles (EVs) represent a heterogeneous population of membranous cell-derived structures, including cargo-oriented exosomes and microvesicles. EVs are functionally associated with intercellular communication and play an essential role in multiple physiopathological conditions. Shedding of EVs is frequently increased in malignancies and their content, including proteins and nucleic acids, altered during carcinogenesis and cancer progression. EVs-mediated intercellular communication between tumor cells and between tumor and stromal cells can modulate, through cargo miRNA, the survival, progression, and drug resistance in cancer conditions. These consolidated suggestions and EVs’ stability in bodily fluids have led to extensive investigations on the potential employment of circulating EVs-derived miRNAs as tumor biomarkers and potential therapeutic vehicles. In this review, we highlight the current knowledge about circulating EVs-miRNAs in human cancer and the application limits of these tools, discussing their clinical utility and challenges in functions such as in biomarkers and instruments for diagnosis, prognosis, and therapy.
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spelling pubmed-75559722020-10-19 Extracellular Vesicles: New Endogenous Shuttles for miRNAs in Cancer Diagnosis and Therapy? Martellucci, Stefano Orefice, Nicola Salvatore Angelucci, Adriano Luce, Amalia Caraglia, Michele Zappavigna, Silvia Int J Mol Sci Review Extracellular Vesicles (EVs) represent a heterogeneous population of membranous cell-derived structures, including cargo-oriented exosomes and microvesicles. EVs are functionally associated with intercellular communication and play an essential role in multiple physiopathological conditions. Shedding of EVs is frequently increased in malignancies and their content, including proteins and nucleic acids, altered during carcinogenesis and cancer progression. EVs-mediated intercellular communication between tumor cells and between tumor and stromal cells can modulate, through cargo miRNA, the survival, progression, and drug resistance in cancer conditions. These consolidated suggestions and EVs’ stability in bodily fluids have led to extensive investigations on the potential employment of circulating EVs-derived miRNAs as tumor biomarkers and potential therapeutic vehicles. In this review, we highlight the current knowledge about circulating EVs-miRNAs in human cancer and the application limits of these tools, discussing their clinical utility and challenges in functions such as in biomarkers and instruments for diagnosis, prognosis, and therapy. MDPI 2020-09-04 /pmc/articles/PMC7555972/ /pubmed/32899898 http://dx.doi.org/10.3390/ijms21186486 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martellucci, Stefano
Orefice, Nicola Salvatore
Angelucci, Adriano
Luce, Amalia
Caraglia, Michele
Zappavigna, Silvia
Extracellular Vesicles: New Endogenous Shuttles for miRNAs in Cancer Diagnosis and Therapy?
title Extracellular Vesicles: New Endogenous Shuttles for miRNAs in Cancer Diagnosis and Therapy?
title_full Extracellular Vesicles: New Endogenous Shuttles for miRNAs in Cancer Diagnosis and Therapy?
title_fullStr Extracellular Vesicles: New Endogenous Shuttles for miRNAs in Cancer Diagnosis and Therapy?
title_full_unstemmed Extracellular Vesicles: New Endogenous Shuttles for miRNAs in Cancer Diagnosis and Therapy?
title_short Extracellular Vesicles: New Endogenous Shuttles for miRNAs in Cancer Diagnosis and Therapy?
title_sort extracellular vesicles: new endogenous shuttles for mirnas in cancer diagnosis and therapy?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555972/
https://www.ncbi.nlm.nih.gov/pubmed/32899898
http://dx.doi.org/10.3390/ijms21186486
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