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A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids

Liver fibrosis resulting from continuous long-term hepatic damage represents a heavy burden worldwide. Liver fibrosis is recognized as a complicated pathogenic mechanism with extracellular matrix (ECM) accumulation and hepatic stellate cell (HSC) activation. A series of drugs demonstrate significant...

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Autores principales: Pan, Xiaoqi, Ma, Xiao, Jiang, Yinxiao, Wen, Jianxia, Yang, Lian, Chen, Dayi, Cao, Xiaoyu, Peng, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556091/
https://www.ncbi.nlm.nih.gov/pubmed/33082829
http://dx.doi.org/10.1155/2020/7171498
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author Pan, Xiaoqi
Ma, Xiao
Jiang, Yinxiao
Wen, Jianxia
Yang, Lian
Chen, Dayi
Cao, Xiaoyu
Peng, Cheng
author_facet Pan, Xiaoqi
Ma, Xiao
Jiang, Yinxiao
Wen, Jianxia
Yang, Lian
Chen, Dayi
Cao, Xiaoyu
Peng, Cheng
author_sort Pan, Xiaoqi
collection PubMed
description Liver fibrosis resulting from continuous long-term hepatic damage represents a heavy burden worldwide. Liver fibrosis is recognized as a complicated pathogenic mechanism with extracellular matrix (ECM) accumulation and hepatic stellate cell (HSC) activation. A series of drugs demonstrate significant antifibrotic activity in vitro and in vivo. No specific agents with ideally clinical efficacy for liver fibrosis treatment have been developed. In this review, we summarized the antifibrotic effects and molecular mechanisms of 29 kinds of common natural products. The mechanism of these compounds is correlated with anti-inflammatory, antiapoptotic, and antifibrotic activities. Moreover, parenchymal hepatic cell survival, HSC deactivation, and ECM degradation by interfering with multiple targets and signaling pathways are also involved in the antifibrotic effects of these compounds. However, there remain two bottlenecks for clinical breakthroughs. The low bioavailability of natural products should be improved, and the combined application of two or more compounds should be investigated for more prominent pharmacological effects. In summary, exploration on natural products against liver fibrosis is becoming increasingly extensive. Therefore, natural products are potential resources for the development of agents to treat liver fibrosis.
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spelling pubmed-75560912020-10-19 A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids Pan, Xiaoqi Ma, Xiao Jiang, Yinxiao Wen, Jianxia Yang, Lian Chen, Dayi Cao, Xiaoyu Peng, Cheng Evid Based Complement Alternat Med Review Article Liver fibrosis resulting from continuous long-term hepatic damage represents a heavy burden worldwide. Liver fibrosis is recognized as a complicated pathogenic mechanism with extracellular matrix (ECM) accumulation and hepatic stellate cell (HSC) activation. A series of drugs demonstrate significant antifibrotic activity in vitro and in vivo. No specific agents with ideally clinical efficacy for liver fibrosis treatment have been developed. In this review, we summarized the antifibrotic effects and molecular mechanisms of 29 kinds of common natural products. The mechanism of these compounds is correlated with anti-inflammatory, antiapoptotic, and antifibrotic activities. Moreover, parenchymal hepatic cell survival, HSC deactivation, and ECM degradation by interfering with multiple targets and signaling pathways are also involved in the antifibrotic effects of these compounds. However, there remain two bottlenecks for clinical breakthroughs. The low bioavailability of natural products should be improved, and the combined application of two or more compounds should be investigated for more prominent pharmacological effects. In summary, exploration on natural products against liver fibrosis is becoming increasingly extensive. Therefore, natural products are potential resources for the development of agents to treat liver fibrosis. Hindawi 2020-10-05 /pmc/articles/PMC7556091/ /pubmed/33082829 http://dx.doi.org/10.1155/2020/7171498 Text en Copyright © 2020 Xiaoqi Pan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pan, Xiaoqi
Ma, Xiao
Jiang, Yinxiao
Wen, Jianxia
Yang, Lian
Chen, Dayi
Cao, Xiaoyu
Peng, Cheng
A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids
title A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids
title_full A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids
title_fullStr A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids
title_full_unstemmed A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids
title_short A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids
title_sort comprehensive review of natural products against liver fibrosis: flavonoids, quinones, lignans, phenols, and acids
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556091/
https://www.ncbi.nlm.nih.gov/pubmed/33082829
http://dx.doi.org/10.1155/2020/7171498
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