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Interplay Between Diabetes and Pancreatic Ductal Adenocarcinoma and Insulinoma: The Role of Aging, Genetic Factors, and Obesity

Epidemiologic analyses have shed light on an association between type 2 diabetes (T2D) and pancreatic ductal adenocarcinoma (PDAC). Recent data also suggest a potential relationship between T2D and insulinoma. Under rare circumstances, type 1 diabetes (T1D) can also be implicated in tumorigenesis. T...

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Autores principales: Duvillié, Bertrand, Kourdoughli, Rayane, Druillennec, Sabine, Eychène, Alain, Pouponnot, Celio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556217/
https://www.ncbi.nlm.nih.gov/pubmed/33101198
http://dx.doi.org/10.3389/fendo.2020.563267
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author Duvillié, Bertrand
Kourdoughli, Rayane
Druillennec, Sabine
Eychène, Alain
Pouponnot, Celio
author_facet Duvillié, Bertrand
Kourdoughli, Rayane
Druillennec, Sabine
Eychène, Alain
Pouponnot, Celio
author_sort Duvillié, Bertrand
collection PubMed
description Epidemiologic analyses have shed light on an association between type 2 diabetes (T2D) and pancreatic ductal adenocarcinoma (PDAC). Recent data also suggest a potential relationship between T2D and insulinoma. Under rare circumstances, type 1 diabetes (T1D) can also be implicated in tumorigenesis. The biological mechanisms underlying such relationships are extremely complex. Some genetic factors contributing to the development of T2D are shared with pancreatic exocrine and endocrine tumors. Obesity and overweight can also contribute to the initiation and severity of T2D, while aging may influence both endocrine and exocrine tumors. Finally, pharmacological treatments of T2D may have an impact on PDAC. On the other hand, some treatments for insulinoma can trigger diabetes. In the present minireview, we discuss the cellular and molecular mechanisms that could explain these interactions. This analysis may help to define new potential therapeutic strategies.
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spelling pubmed-75562172020-10-22 Interplay Between Diabetes and Pancreatic Ductal Adenocarcinoma and Insulinoma: The Role of Aging, Genetic Factors, and Obesity Duvillié, Bertrand Kourdoughli, Rayane Druillennec, Sabine Eychène, Alain Pouponnot, Celio Front Endocrinol (Lausanne) Endocrinology Epidemiologic analyses have shed light on an association between type 2 diabetes (T2D) and pancreatic ductal adenocarcinoma (PDAC). Recent data also suggest a potential relationship between T2D and insulinoma. Under rare circumstances, type 1 diabetes (T1D) can also be implicated in tumorigenesis. The biological mechanisms underlying such relationships are extremely complex. Some genetic factors contributing to the development of T2D are shared with pancreatic exocrine and endocrine tumors. Obesity and overweight can also contribute to the initiation and severity of T2D, while aging may influence both endocrine and exocrine tumors. Finally, pharmacological treatments of T2D may have an impact on PDAC. On the other hand, some treatments for insulinoma can trigger diabetes. In the present minireview, we discuss the cellular and molecular mechanisms that could explain these interactions. This analysis may help to define new potential therapeutic strategies. Frontiers Media S.A. 2020-09-30 /pmc/articles/PMC7556217/ /pubmed/33101198 http://dx.doi.org/10.3389/fendo.2020.563267 Text en Copyright © 2020 Duvillié, Kourdoughli, Druillennec, Eychène and Pouponnot http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Duvillié, Bertrand
Kourdoughli, Rayane
Druillennec, Sabine
Eychène, Alain
Pouponnot, Celio
Interplay Between Diabetes and Pancreatic Ductal Adenocarcinoma and Insulinoma: The Role of Aging, Genetic Factors, and Obesity
title Interplay Between Diabetes and Pancreatic Ductal Adenocarcinoma and Insulinoma: The Role of Aging, Genetic Factors, and Obesity
title_full Interplay Between Diabetes and Pancreatic Ductal Adenocarcinoma and Insulinoma: The Role of Aging, Genetic Factors, and Obesity
title_fullStr Interplay Between Diabetes and Pancreatic Ductal Adenocarcinoma and Insulinoma: The Role of Aging, Genetic Factors, and Obesity
title_full_unstemmed Interplay Between Diabetes and Pancreatic Ductal Adenocarcinoma and Insulinoma: The Role of Aging, Genetic Factors, and Obesity
title_short Interplay Between Diabetes and Pancreatic Ductal Adenocarcinoma and Insulinoma: The Role of Aging, Genetic Factors, and Obesity
title_sort interplay between diabetes and pancreatic ductal adenocarcinoma and insulinoma: the role of aging, genetic factors, and obesity
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556217/
https://www.ncbi.nlm.nih.gov/pubmed/33101198
http://dx.doi.org/10.3389/fendo.2020.563267
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