Metabolic Profiling of a CB2 Agonist, AM9338, Using LC-MS and Microcoil-NMR: Identification of a Novel Dihydroxy Adamantyl Metabolite

Adamantyl groups are key structural subunit commonly used in many marketed drugs targeting diseases ranging from viral infections to neurological disorders. The metabolic disposition of adamantyl compounds has been mostly studied using LC-MS based approaches. However, metabolite quantities isolated...

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Detalles Bibliográficos
Autores principales: Honrao, Chandrashekhar, Ma, Xiaoyu, Kulkarni, Shashank, Joshi, Vinit, Malamas, Michael, Zvonok, Alexander, Wood, JodiAnne, Kautz, Roger A., Strand, David, Guo, Jason J., Makriyannis, Alexandros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556269/
https://www.ncbi.nlm.nih.gov/pubmed/33101030
http://dx.doi.org/10.3389/fphar.2020.575691

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