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Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning

Hypoxic/ischemic preconditioning (HPC/IPC) is an innate neuroprotective mechanism in which a number of endogenous molecules are known to be involved. Tuberous sclerosis complex 1 (TSC1), also known as hamartin, is thought to be one such molecule. It is also known that hamartin is involved as a targe...

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Autores principales: Li, Sijie, Ren, Changhong, Stone, Christopher, Chandra, Ankush, Xu, Jiali, Li, Ning, Han, Cong, Ding, Yuchuan, Ji, Xunming, Shao, Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556298/
https://www.ncbi.nlm.nih.gov/pubmed/33193709
http://dx.doi.org/10.3389/fgene.2020.582368
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author Li, Sijie
Ren, Changhong
Stone, Christopher
Chandra, Ankush
Xu, Jiali
Li, Ning
Han, Cong
Ding, Yuchuan
Ji, Xunming
Shao, Guo
author_facet Li, Sijie
Ren, Changhong
Stone, Christopher
Chandra, Ankush
Xu, Jiali
Li, Ning
Han, Cong
Ding, Yuchuan
Ji, Xunming
Shao, Guo
author_sort Li, Sijie
collection PubMed
description Hypoxic/ischemic preconditioning (HPC/IPC) is an innate neuroprotective mechanism in which a number of endogenous molecules are known to be involved. Tuberous sclerosis complex 1 (TSC1), also known as hamartin, is thought to be one such molecule. It is also known that hamartin is involved as a target in the rapamycin (mTOR) signaling pathway, which functions to integrate a variety of environmental triggers in order to exert control over cellular metabolism and homeostasis. Understanding the role of hamartin in ischemic/hypoxic neuroprotection will provide a novel target for the treatment of hypoxic-ischemic disease. Therefore, the proposed molecular mechanisms of this neuroprotective role and its preconditions are reviewed in this paper, with emphases on the mTOR pathway and the relationship between the expression of hamartin and DNA methylation.
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spelling pubmed-75562982020-11-13 Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning Li, Sijie Ren, Changhong Stone, Christopher Chandra, Ankush Xu, Jiali Li, Ning Han, Cong Ding, Yuchuan Ji, Xunming Shao, Guo Front Genet Genetics Hypoxic/ischemic preconditioning (HPC/IPC) is an innate neuroprotective mechanism in which a number of endogenous molecules are known to be involved. Tuberous sclerosis complex 1 (TSC1), also known as hamartin, is thought to be one such molecule. It is also known that hamartin is involved as a target in the rapamycin (mTOR) signaling pathway, which functions to integrate a variety of environmental triggers in order to exert control over cellular metabolism and homeostasis. Understanding the role of hamartin in ischemic/hypoxic neuroprotection will provide a novel target for the treatment of hypoxic-ischemic disease. Therefore, the proposed molecular mechanisms of this neuroprotective role and its preconditions are reviewed in this paper, with emphases on the mTOR pathway and the relationship between the expression of hamartin and DNA methylation. Frontiers Media S.A. 2020-09-30 /pmc/articles/PMC7556298/ /pubmed/33193709 http://dx.doi.org/10.3389/fgene.2020.582368 Text en Copyright © 2020 Li, Ren, Stone, Chandra, Xu, Li, Han, Ding, Ji and Shao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Li, Sijie
Ren, Changhong
Stone, Christopher
Chandra, Ankush
Xu, Jiali
Li, Ning
Han, Cong
Ding, Yuchuan
Ji, Xunming
Shao, Guo
Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning
title Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning
title_full Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning
title_fullStr Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning
title_full_unstemmed Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning
title_short Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning
title_sort hamartin: an endogenous neuroprotective molecule induced by hypoxic preconditioning
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556298/
https://www.ncbi.nlm.nih.gov/pubmed/33193709
http://dx.doi.org/10.3389/fgene.2020.582368
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