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Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning
Hypoxic/ischemic preconditioning (HPC/IPC) is an innate neuroprotective mechanism in which a number of endogenous molecules are known to be involved. Tuberous sclerosis complex 1 (TSC1), also known as hamartin, is thought to be one such molecule. It is also known that hamartin is involved as a targe...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556298/ https://www.ncbi.nlm.nih.gov/pubmed/33193709 http://dx.doi.org/10.3389/fgene.2020.582368 |
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author | Li, Sijie Ren, Changhong Stone, Christopher Chandra, Ankush Xu, Jiali Li, Ning Han, Cong Ding, Yuchuan Ji, Xunming Shao, Guo |
author_facet | Li, Sijie Ren, Changhong Stone, Christopher Chandra, Ankush Xu, Jiali Li, Ning Han, Cong Ding, Yuchuan Ji, Xunming Shao, Guo |
author_sort | Li, Sijie |
collection | PubMed |
description | Hypoxic/ischemic preconditioning (HPC/IPC) is an innate neuroprotective mechanism in which a number of endogenous molecules are known to be involved. Tuberous sclerosis complex 1 (TSC1), also known as hamartin, is thought to be one such molecule. It is also known that hamartin is involved as a target in the rapamycin (mTOR) signaling pathway, which functions to integrate a variety of environmental triggers in order to exert control over cellular metabolism and homeostasis. Understanding the role of hamartin in ischemic/hypoxic neuroprotection will provide a novel target for the treatment of hypoxic-ischemic disease. Therefore, the proposed molecular mechanisms of this neuroprotective role and its preconditions are reviewed in this paper, with emphases on the mTOR pathway and the relationship between the expression of hamartin and DNA methylation. |
format | Online Article Text |
id | pubmed-7556298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75562982020-11-13 Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning Li, Sijie Ren, Changhong Stone, Christopher Chandra, Ankush Xu, Jiali Li, Ning Han, Cong Ding, Yuchuan Ji, Xunming Shao, Guo Front Genet Genetics Hypoxic/ischemic preconditioning (HPC/IPC) is an innate neuroprotective mechanism in which a number of endogenous molecules are known to be involved. Tuberous sclerosis complex 1 (TSC1), also known as hamartin, is thought to be one such molecule. It is also known that hamartin is involved as a target in the rapamycin (mTOR) signaling pathway, which functions to integrate a variety of environmental triggers in order to exert control over cellular metabolism and homeostasis. Understanding the role of hamartin in ischemic/hypoxic neuroprotection will provide a novel target for the treatment of hypoxic-ischemic disease. Therefore, the proposed molecular mechanisms of this neuroprotective role and its preconditions are reviewed in this paper, with emphases on the mTOR pathway and the relationship between the expression of hamartin and DNA methylation. Frontiers Media S.A. 2020-09-30 /pmc/articles/PMC7556298/ /pubmed/33193709 http://dx.doi.org/10.3389/fgene.2020.582368 Text en Copyright © 2020 Li, Ren, Stone, Chandra, Xu, Li, Han, Ding, Ji and Shao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Li, Sijie Ren, Changhong Stone, Christopher Chandra, Ankush Xu, Jiali Li, Ning Han, Cong Ding, Yuchuan Ji, Xunming Shao, Guo Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning |
title | Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning |
title_full | Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning |
title_fullStr | Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning |
title_full_unstemmed | Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning |
title_short | Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning |
title_sort | hamartin: an endogenous neuroprotective molecule induced by hypoxic preconditioning |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556298/ https://www.ncbi.nlm.nih.gov/pubmed/33193709 http://dx.doi.org/10.3389/fgene.2020.582368 |
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