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Licensed Bacille Calmette-Guérin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation

BACKGROUND: Bacille Calmette-Guérin (BCG), the live attenuated tuberculosis vaccine, is manufactured under different conditions across the globe generating formulations that may differ in clinical efficacy. Innate immune recognition of live BCG contributes to immunogenicity suggesting that differenc...

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Detalles Bibliográficos
Autores principales:	Angelidou, Asimenia, Conti, Maria-Giulia, Diray-Arce, Joann, Benn, Christine S., Shann, Frank, Netea, Mihai G., Liu, Mark, Potluri, Lakshmi Prasad, Sanchez-Schmitz, Guzman, Husson, Robert, Ozonoff, Al, Kampmann, Beate, van Haren, Simon Daniël, Levy, Ofer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556328/ https://www.ncbi.nlm.nih.gov/pubmed/32005538 http://dx.doi.org/10.1016/j.vaccine.2019.11.060

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