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Optical characteristics after Descemet membrane endothelial keratoplasty: 1-year results

PURPOSE: To evaluate the corneal characteristics after Descemet membrane endothelial keratoplasty (DMEK) compared with normal corneas. METHODS: Patients who underwent DMEK at Yokohama Minami Kyosai Hospital were included and prospectively evaluated pre-operatively and at postoperative months 1, 3, 6...

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Autores principales: Hayashi, Takahiko, Kobayashi, Akira, Takahashi, Hidenori, Oyakawa, Itaru, Kato, Naoko, Yamaguchi, Takefumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556451/
https://www.ncbi.nlm.nih.gov/pubmed/33052928
http://dx.doi.org/10.1371/journal.pone.0240458
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author Hayashi, Takahiko
Kobayashi, Akira
Takahashi, Hidenori
Oyakawa, Itaru
Kato, Naoko
Yamaguchi, Takefumi
author_facet Hayashi, Takahiko
Kobayashi, Akira
Takahashi, Hidenori
Oyakawa, Itaru
Kato, Naoko
Yamaguchi, Takefumi
author_sort Hayashi, Takahiko
collection PubMed
description PURPOSE: To evaluate the corneal characteristics after Descemet membrane endothelial keratoplasty (DMEK) compared with normal corneas. METHODS: Patients who underwent DMEK at Yokohama Minami Kyosai Hospital were included and prospectively evaluated pre-operatively and at postoperative months 1, 3, 6, and 12, and compared to healthy controls. Corneal characteristics evaluated included corneal curvature (keratometric value [KV]; D), central corneal thickness (CCT), peripheral corneal thickness (PCT), and corneal higher-order aberrations [HOAs] at 6.0 mm diameter, calculated by anterior segment optical coherence tomography and logarithm of the minimal angle of resolution [logMAR]. RESULTS: A total of 30 eyes of 30 patients (6 men, 24 women, mean age 73.4 ± 7.4 years) were included and compared with 31 age-matched healthy control eyes (13 men, 18 women; mean age 73.0 ± 6.7 years). LogMAR after DMEK improved from 0.87 ± 0.07 preoperatively to 0.04 ± 0.07 at 12 months postoperatively (p<0.001). Although anterior KVs of DMEK eyes were similar to those of control eyes, posterior KVs were significantly larger (-6.4 ± 0.3 D vs. -6.3 ± 0.2 D; p = 0.02). Total HOAs after DMEK improved from 1.94 ± 1.05 μm preoperatively to 1.05 ± 0.16 μm at 12 months postoperatively (p<0.001), which was significantly higher than that in control eyes (0.63 ± 0.06) (p<0.001). Despite the similar CCTs in the two groups, the PCT was significantly larger in DMEK eyes (704 ± 41 μm vs 669 ± 38 μm, p = 0.002) at 12 months. CONCLUSION: Despite achieving good visual function and excellent corneal clarity, eyes that underwent DMEK showed a steeper posterior KV and higher corneal HOAs than normal eyes even at 12 months after surgery.
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spelling pubmed-75564512020-10-21 Optical characteristics after Descemet membrane endothelial keratoplasty: 1-year results Hayashi, Takahiko Kobayashi, Akira Takahashi, Hidenori Oyakawa, Itaru Kato, Naoko Yamaguchi, Takefumi PLoS One Research Article PURPOSE: To evaluate the corneal characteristics after Descemet membrane endothelial keratoplasty (DMEK) compared with normal corneas. METHODS: Patients who underwent DMEK at Yokohama Minami Kyosai Hospital were included and prospectively evaluated pre-operatively and at postoperative months 1, 3, 6, and 12, and compared to healthy controls. Corneal characteristics evaluated included corneal curvature (keratometric value [KV]; D), central corneal thickness (CCT), peripheral corneal thickness (PCT), and corneal higher-order aberrations [HOAs] at 6.0 mm diameter, calculated by anterior segment optical coherence tomography and logarithm of the minimal angle of resolution [logMAR]. RESULTS: A total of 30 eyes of 30 patients (6 men, 24 women, mean age 73.4 ± 7.4 years) were included and compared with 31 age-matched healthy control eyes (13 men, 18 women; mean age 73.0 ± 6.7 years). LogMAR after DMEK improved from 0.87 ± 0.07 preoperatively to 0.04 ± 0.07 at 12 months postoperatively (p<0.001). Although anterior KVs of DMEK eyes were similar to those of control eyes, posterior KVs were significantly larger (-6.4 ± 0.3 D vs. -6.3 ± 0.2 D; p = 0.02). Total HOAs after DMEK improved from 1.94 ± 1.05 μm preoperatively to 1.05 ± 0.16 μm at 12 months postoperatively (p<0.001), which was significantly higher than that in control eyes (0.63 ± 0.06) (p<0.001). Despite the similar CCTs in the two groups, the PCT was significantly larger in DMEK eyes (704 ± 41 μm vs 669 ± 38 μm, p = 0.002) at 12 months. CONCLUSION: Despite achieving good visual function and excellent corneal clarity, eyes that underwent DMEK showed a steeper posterior KV and higher corneal HOAs than normal eyes even at 12 months after surgery. Public Library of Science 2020-10-14 /pmc/articles/PMC7556451/ /pubmed/33052928 http://dx.doi.org/10.1371/journal.pone.0240458 Text en © 2020 Hayashi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hayashi, Takahiko
Kobayashi, Akira
Takahashi, Hidenori
Oyakawa, Itaru
Kato, Naoko
Yamaguchi, Takefumi
Optical characteristics after Descemet membrane endothelial keratoplasty: 1-year results
title Optical characteristics after Descemet membrane endothelial keratoplasty: 1-year results
title_full Optical characteristics after Descemet membrane endothelial keratoplasty: 1-year results
title_fullStr Optical characteristics after Descemet membrane endothelial keratoplasty: 1-year results
title_full_unstemmed Optical characteristics after Descemet membrane endothelial keratoplasty: 1-year results
title_short Optical characteristics after Descemet membrane endothelial keratoplasty: 1-year results
title_sort optical characteristics after descemet membrane endothelial keratoplasty: 1-year results
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556451/
https://www.ncbi.nlm.nih.gov/pubmed/33052928
http://dx.doi.org/10.1371/journal.pone.0240458
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