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Mortality, morbidity and clinical care in a referral neonatal intensive care unit in Haiti

BACKGROUND: Neonatal mortality rates in Haiti are among the highest in the Western hemisphere. Few mothers deliver with a skilled birth attendant present, and there is a significant lack of pediatricians. The neonatal intensive care unit (NICU) at St. Damien Pediatric Hospital, a national referral c...

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Autores principales: Valcin, Josie, Jean-Charles, Skenda, Malfa, Ana, Tucker, Richard, Dorcélus, Lindsay, Gautier, Jacqueline, Koster, Michael P., Lechner, Beatrice E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556516/
https://www.ncbi.nlm.nih.gov/pubmed/33052937
http://dx.doi.org/10.1371/journal.pone.0240465
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author Valcin, Josie
Jean-Charles, Skenda
Malfa, Ana
Tucker, Richard
Dorcélus, Lindsay
Gautier, Jacqueline
Koster, Michael P.
Lechner, Beatrice E.
author_facet Valcin, Josie
Jean-Charles, Skenda
Malfa, Ana
Tucker, Richard
Dorcélus, Lindsay
Gautier, Jacqueline
Koster, Michael P.
Lechner, Beatrice E.
author_sort Valcin, Josie
collection PubMed
description BACKGROUND: Neonatal mortality rates in Haiti are among the highest in the Western hemisphere. Few mothers deliver with a skilled birth attendant present, and there is a significant lack of pediatricians. The neonatal intensive care unit (NICU) at St. Damien Pediatric Hospital, a national referral center, is one of only five neonatology departments in Haiti. In order to target limited resources toward improving outcomes, this study seeks to describe clinical care in the St. Damien NICU. METHODS: A retrospective medical record review was performed on available medical records on all admissions to the NICU between April 2016 and April 2017. RESULTS: 220 neonates were admitted to the NICU within the study epoch. The mortality rate was 14.5%. Death was associated with a maternal diagnosis of hypertension (p = 0.03) and neonatal diagnoses of lower gestational age (p<0.0001), lower birth weight (p<0.0001), prematurity (p = 0.002), RDS p = 0.01), sepsis (p<0.0001) and kernicterus (p = 0.04). The most common diagnoses were sepsis, chorioamnionitis, respiratory distress syndrome, jaundice, prematurity and perinatal asphyxia. CONCLUSIONS: This study demonstrates that preterm birth, sepsis, RDS and kernicterus are key contributors to neonatal mortality in a Haitian national pediatric referral center NICU and as such are promising interventional targets for reducing the neonatal mortality rate in Haiti.
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spelling pubmed-75565162020-10-21 Mortality, morbidity and clinical care in a referral neonatal intensive care unit in Haiti Valcin, Josie Jean-Charles, Skenda Malfa, Ana Tucker, Richard Dorcélus, Lindsay Gautier, Jacqueline Koster, Michael P. Lechner, Beatrice E. PLoS One Research Article BACKGROUND: Neonatal mortality rates in Haiti are among the highest in the Western hemisphere. Few mothers deliver with a skilled birth attendant present, and there is a significant lack of pediatricians. The neonatal intensive care unit (NICU) at St. Damien Pediatric Hospital, a national referral center, is one of only five neonatology departments in Haiti. In order to target limited resources toward improving outcomes, this study seeks to describe clinical care in the St. Damien NICU. METHODS: A retrospective medical record review was performed on available medical records on all admissions to the NICU between April 2016 and April 2017. RESULTS: 220 neonates were admitted to the NICU within the study epoch. The mortality rate was 14.5%. Death was associated with a maternal diagnosis of hypertension (p = 0.03) and neonatal diagnoses of lower gestational age (p<0.0001), lower birth weight (p<0.0001), prematurity (p = 0.002), RDS p = 0.01), sepsis (p<0.0001) and kernicterus (p = 0.04). The most common diagnoses were sepsis, chorioamnionitis, respiratory distress syndrome, jaundice, prematurity and perinatal asphyxia. CONCLUSIONS: This study demonstrates that preterm birth, sepsis, RDS and kernicterus are key contributors to neonatal mortality in a Haitian national pediatric referral center NICU and as such are promising interventional targets for reducing the neonatal mortality rate in Haiti. Public Library of Science 2020-10-14 /pmc/articles/PMC7556516/ /pubmed/33052937 http://dx.doi.org/10.1371/journal.pone.0240465 Text en © 2020 Valcin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Valcin, Josie
Jean-Charles, Skenda
Malfa, Ana
Tucker, Richard
Dorcélus, Lindsay
Gautier, Jacqueline
Koster, Michael P.
Lechner, Beatrice E.
Mortality, morbidity and clinical care in a referral neonatal intensive care unit in Haiti
title Mortality, morbidity and clinical care in a referral neonatal intensive care unit in Haiti
title_full Mortality, morbidity and clinical care in a referral neonatal intensive care unit in Haiti
title_fullStr Mortality, morbidity and clinical care in a referral neonatal intensive care unit in Haiti
title_full_unstemmed Mortality, morbidity and clinical care in a referral neonatal intensive care unit in Haiti
title_short Mortality, morbidity and clinical care in a referral neonatal intensive care unit in Haiti
title_sort mortality, morbidity and clinical care in a referral neonatal intensive care unit in haiti
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556516/
https://www.ncbi.nlm.nih.gov/pubmed/33052937
http://dx.doi.org/10.1371/journal.pone.0240465
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