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In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer

Docetaxel chemotherapy in metastatic prostate cancer offers only a modest survival benefit because of emerging resistance. To identify candidate therapeutic gene targets, we applied a murine prostate cancer orthograft model that recapitulates clinical invasive prostate cancer in a genome-wide CRISPR...

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Detalles Bibliográficos
Autores principales:	Rushworth, Linda K, Harle, Victoria, Repiscak, Peter, Clark, William, Shaw, Robin, Hall, Holly, Bushell, Martin, Leung, Hing Y, Patel, Rachana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556750/ https://www.ncbi.nlm.nih.gov/pubmed/33033111 http://dx.doi.org/10.26508/lsa.202000770

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