An NF-κB–driven lncRNA orchestrates colitis and circadian clock

We uncover a cycling and NF-κB–driven lncRNA (named Lnc-UC) that epigenetically modifies transcription of circadian clock gene Rev-erbα, thereby linking circadian clock to colitis. Cycling expression of Lnc-UC is generated by the central clock protein Bmal1 via an E-box element. NF-κB activation in...

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Detalles Bibliográficos
Autores principales: Wang, Shuai, Lin, Yanke, Li, Feng, Qin, Zifei, Zhou, Ziyue, Gao, Lu, Yang, Zemin, Wang, Zhigang, Wu, Baojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556837/
https://www.ncbi.nlm.nih.gov/pubmed/33055157
http://dx.doi.org/10.1126/sciadv.abb5202

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