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A mathematical model for HIV prevention and control among men who have sex with men in China
In recent years, men who have sex with men (MSM) constitute a major group of HIV transmission in China. High primary drug-resistance (PDR) rate in MSM also represents a serious challenge for the Chinese antiretroviral therapy (ART) program. To assess the efficiency of ART in controlling HIV/AIDS inf...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556994/ https://www.ncbi.nlm.nih.gov/pubmed/32336300 http://dx.doi.org/10.1017/S0950268820000850 |
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author | Lu, Z. Wang, L. Wang, L. P. Xing, H. Fu, G. Yan, H. Wang, L. Li, Z. Xu, J. Wang, N. Wang, K. Peng, Z. |
author_facet | Lu, Z. Wang, L. Wang, L. P. Xing, H. Fu, G. Yan, H. Wang, L. Li, Z. Xu, J. Wang, N. Wang, K. Peng, Z. |
author_sort | Lu, Z. |
collection | PubMed |
description | In recent years, men who have sex with men (MSM) constitute a major group of HIV transmission in China. High primary drug-resistance (PDR) rate in MSM also represents a serious challenge for the Chinese antiretroviral therapy (ART) program. To assess the efficiency of ART in controlling HIV/AIDS infection among MSM, we developed a compartmental model for the annually reported HIV/AIDS MSM from 2007 to 2019 in the Zhejiang Province of China. R(0) was 2.3946 (95% CI (2.2961–2.4881)). We predict that 90% of diagnosed HIV/AIDS individuals will have received treatment till 2020, while the proportion of the diagnosed remains as low as 40%. Even when the proportion of the diagnosed reaches 90%, R(0) is still larger than the level of AIDS epidemic elimination. ART can effectively control the spread of HIV, even in the presence of drug resistance. The 90-90-90 strategy alone may not eliminate the HIV epidemic in Chinese MSM. Behavioural and biologic interventions are the most effective interventions to control the HIV/AIDS epidemic among MSM. |
format | Online Article Text |
id | pubmed-7556994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-75569942020-10-23 A mathematical model for HIV prevention and control among men who have sex with men in China Lu, Z. Wang, L. Wang, L. P. Xing, H. Fu, G. Yan, H. Wang, L. Li, Z. Xu, J. Wang, N. Wang, K. Peng, Z. Epidemiol Infect Original Paper In recent years, men who have sex with men (MSM) constitute a major group of HIV transmission in China. High primary drug-resistance (PDR) rate in MSM also represents a serious challenge for the Chinese antiretroviral therapy (ART) program. To assess the efficiency of ART in controlling HIV/AIDS infection among MSM, we developed a compartmental model for the annually reported HIV/AIDS MSM from 2007 to 2019 in the Zhejiang Province of China. R(0) was 2.3946 (95% CI (2.2961–2.4881)). We predict that 90% of diagnosed HIV/AIDS individuals will have received treatment till 2020, while the proportion of the diagnosed remains as low as 40%. Even when the proportion of the diagnosed reaches 90%, R(0) is still larger than the level of AIDS epidemic elimination. ART can effectively control the spread of HIV, even in the presence of drug resistance. The 90-90-90 strategy alone may not eliminate the HIV epidemic in Chinese MSM. Behavioural and biologic interventions are the most effective interventions to control the HIV/AIDS epidemic among MSM. Cambridge University Press 2020-04-27 /pmc/articles/PMC7556994/ /pubmed/32336300 http://dx.doi.org/10.1017/S0950268820000850 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by-nc-sa/4.0/ http://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http://creativecommons.org/licenses/by-nc-sa/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is included and the original work is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use. |
spellingShingle | Original Paper Lu, Z. Wang, L. Wang, L. P. Xing, H. Fu, G. Yan, H. Wang, L. Li, Z. Xu, J. Wang, N. Wang, K. Peng, Z. A mathematical model for HIV prevention and control among men who have sex with men in China |
title | A mathematical model for HIV prevention and control among men who have sex with men in China |
title_full | A mathematical model for HIV prevention and control among men who have sex with men in China |
title_fullStr | A mathematical model for HIV prevention and control among men who have sex with men in China |
title_full_unstemmed | A mathematical model for HIV prevention and control among men who have sex with men in China |
title_short | A mathematical model for HIV prevention and control among men who have sex with men in China |
title_sort | mathematical model for hiv prevention and control among men who have sex with men in china |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556994/ https://www.ncbi.nlm.nih.gov/pubmed/32336300 http://dx.doi.org/10.1017/S0950268820000850 |
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