Cargando…

A mathematical model for HIV prevention and control among men who have sex with men in China

In recent years, men who have sex with men (MSM) constitute a major group of HIV transmission in China. High primary drug-resistance (PDR) rate in MSM also represents a serious challenge for the Chinese antiretroviral therapy (ART) program. To assess the efficiency of ART in controlling HIV/AIDS inf...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Z., Wang, L., Wang, L. P., Xing, H., Fu, G., Yan, H., Li, Z., Xu, J., Wang, N., Wang, K., Peng, Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556994/
https://www.ncbi.nlm.nih.gov/pubmed/32336300
http://dx.doi.org/10.1017/S0950268820000850
_version_ 1783594324924039168
author Lu, Z.
Wang, L.
Wang, L. P.
Xing, H.
Fu, G.
Yan, H.
Wang, L.
Li, Z.
Xu, J.
Wang, N.
Wang, K.
Peng, Z.
author_facet Lu, Z.
Wang, L.
Wang, L. P.
Xing, H.
Fu, G.
Yan, H.
Wang, L.
Li, Z.
Xu, J.
Wang, N.
Wang, K.
Peng, Z.
author_sort Lu, Z.
collection PubMed
description In recent years, men who have sex with men (MSM) constitute a major group of HIV transmission in China. High primary drug-resistance (PDR) rate in MSM also represents a serious challenge for the Chinese antiretroviral therapy (ART) program. To assess the efficiency of ART in controlling HIV/AIDS infection among MSM, we developed a compartmental model for the annually reported HIV/AIDS MSM from 2007 to 2019 in the Zhejiang Province of China. R(0) was 2.3946 (95% CI (2.2961–2.4881)). We predict that 90% of diagnosed HIV/AIDS individuals will have received treatment till 2020, while the proportion of the diagnosed remains as low as 40%. Even when the proportion of the diagnosed reaches 90%, R(0) is still larger than the level of AIDS epidemic elimination. ART can effectively control the spread of HIV, even in the presence of drug resistance. The 90-90-90 strategy alone may not eliminate the HIV epidemic in Chinese MSM. Behavioural and biologic interventions are the most effective interventions to control the HIV/AIDS epidemic among MSM.
format Online
Article
Text
id pubmed-7556994
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Cambridge University Press
record_format MEDLINE/PubMed
spelling pubmed-75569942020-10-23 A mathematical model for HIV prevention and control among men who have sex with men in China Lu, Z. Wang, L. Wang, L. P. Xing, H. Fu, G. Yan, H. Wang, L. Li, Z. Xu, J. Wang, N. Wang, K. Peng, Z. Epidemiol Infect Original Paper In recent years, men who have sex with men (MSM) constitute a major group of HIV transmission in China. High primary drug-resistance (PDR) rate in MSM also represents a serious challenge for the Chinese antiretroviral therapy (ART) program. To assess the efficiency of ART in controlling HIV/AIDS infection among MSM, we developed a compartmental model for the annually reported HIV/AIDS MSM from 2007 to 2019 in the Zhejiang Province of China. R(0) was 2.3946 (95% CI (2.2961–2.4881)). We predict that 90% of diagnosed HIV/AIDS individuals will have received treatment till 2020, while the proportion of the diagnosed remains as low as 40%. Even when the proportion of the diagnosed reaches 90%, R(0) is still larger than the level of AIDS epidemic elimination. ART can effectively control the spread of HIV, even in the presence of drug resistance. The 90-90-90 strategy alone may not eliminate the HIV epidemic in Chinese MSM. Behavioural and biologic interventions are the most effective interventions to control the HIV/AIDS epidemic among MSM. Cambridge University Press 2020-04-27 /pmc/articles/PMC7556994/ /pubmed/32336300 http://dx.doi.org/10.1017/S0950268820000850 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by-nc-sa/4.0/ http://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http://creativecommons.org/licenses/by-nc-sa/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is included and the original work is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use.
spellingShingle Original Paper
Lu, Z.
Wang, L.
Wang, L. P.
Xing, H.
Fu, G.
Yan, H.
Wang, L.
Li, Z.
Xu, J.
Wang, N.
Wang, K.
Peng, Z.
A mathematical model for HIV prevention and control among men who have sex with men in China
title A mathematical model for HIV prevention and control among men who have sex with men in China
title_full A mathematical model for HIV prevention and control among men who have sex with men in China
title_fullStr A mathematical model for HIV prevention and control among men who have sex with men in China
title_full_unstemmed A mathematical model for HIV prevention and control among men who have sex with men in China
title_short A mathematical model for HIV prevention and control among men who have sex with men in China
title_sort mathematical model for hiv prevention and control among men who have sex with men in china
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556994/
https://www.ncbi.nlm.nih.gov/pubmed/32336300
http://dx.doi.org/10.1017/S0950268820000850
work_keys_str_mv AT luz amathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT wangl amathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT wanglp amathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT xingh amathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT fug amathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT yanh amathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT wangl amathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT liz amathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT xuj amathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT wangn amathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT wangk amathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT pengz amathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT luz mathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT wangl mathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT wanglp mathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT xingh mathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT fug mathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT yanh mathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT wangl mathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT liz mathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT xuj mathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT wangn mathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT wangk mathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina
AT pengz mathematicalmodelforhivpreventionandcontrolamongmenwhohavesexwithmeninchina