Hock-a-loogie saliva as a diagnostic specimen for SARS-CoV-2 by a PCR-based assay: A diagnostic validity study

To clarify the effect of different respiratory sample types on SARS-CoV-2 detection, we collected throat swabs, nasal swabs and hock-a-loogie saliva or sputum, and compared their detection rates and viral loads. The detection rates of sputum (95.65%, 22/23) and hock-a-loogie saliva (88.09%, 37/42) w...

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Detalles Bibliográficos
Autores principales: Fan, Jian, Yu, Fei, Wang, Xiang, Zou, Qianda, Lou, Bin, Xie, Guoliang, Yang, Xianzhi, Chen, Weizhen, Wang, Qi, Zhang, Dan, Wang, Ruonan, Feng, Baihuan, Dong, Yuejiao, Huang, Li, Teng, Yun, Deng, Zhenzhen, Yu, Ling, Xu, Kaijin, Sheng, Jifang, Zheng, Shufa, Chen, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557199/
https://www.ncbi.nlm.nih.gov/pubmed/33068630
http://dx.doi.org/10.1016/j.cca.2020.10.004
Descripción
Sumario:To clarify the effect of different respiratory sample types on SARS-CoV-2 detection, we collected throat swabs, nasal swabs and hock-a-loogie saliva or sputum, and compared their detection rates and viral loads. The detection rates of sputum (95.65%, 22/23) and hock-a-loogie saliva (88.09%, 37/42) were significantly higher than those in throat swabs (41.54%, 27/65) and nasal swabs (72.31%, 47/65) (P < 0.001). The Ct Values of sputum, hock-a-loogie saliva and nasal swabs were significantly higher than that in throat swabs, whereas no significant difference was observed between sputum and saliva samples. Hock-a-loogie saliva are reliable sample types that can be used to detect SARS-CoV-2, and worthy of clinical promotion.

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