Curcumin Allosterically Inhibits the Dengue NS2B-NS3 Protease by Disrupting Its Active Conformation

[Image: see text] Flaviviruses including dengue virus and Zika virus encode a unique two-component NS2B-NS3 protease essential for maturation/infectivity, thus representing a key target for designing antiflavivirus drugs. Here, for the first time, by NMR and molecular docking, we reveal that curcumi...

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Detalles Bibliográficos
Autores principales: Lim, Liangzhong, Dang, Mei, Roy, Amrita, Kang, Jian, Song, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557217/
https://www.ncbi.nlm.nih.gov/pubmed/33073093
http://dx.doi.org/10.1021/acsomega.0c00039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557217/
https://www.ncbi.nlm.nih.gov/pubmed/33073093
http://dx.doi.org/10.1021/acsomega.0c00039

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