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Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England

BACKGROUND: Understanding of the true asymptomatic rate of infection of SARS-CoV-2 is currently limited, as is understanding of the population-based seroprevalence after the first wave of COVID-19 within the UK. The majority of data thus far come from hospitalised patients, with little focus on gene...

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Autores principales: Wells, Philippa M., Doores, Katie J., Couvreur, Simon, Nunez, Rocio Martinez, Seow, Jeffrey, Graham, Carl, Acors, Sam, Kouphou, Neophytos, Neil, Stuart J.D., Tedder, Richard S., Matos, Pedro M., Poulton, Kate, Lista, Maria Jose, Dickenson, Ruth E., Sertkaya, Helin, Maguire, Thomas J.A., Scourfield, Edward J., Bowyer, Ruth C.E., Hart, Deborah, O'Byrne, Aoife, Steel, Kathryn J.A., Hemmings, Oliver, Rosadas, Carolina, McClure, Myra O., Capedevilla-pujol, Joan, Wolf, Jonathan, Ourselin, Sebastien, Brown, Matthew A., Malim, Michael H., Spector, Tim, Steves, Claire J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of The British Infection Association. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557299/
https://www.ncbi.nlm.nih.gov/pubmed/33068628
http://dx.doi.org/10.1016/j.jinf.2020.10.011
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author Wells, Philippa M.
Doores, Katie J.
Couvreur, Simon
Nunez, Rocio Martinez
Seow, Jeffrey
Graham, Carl
Acors, Sam
Kouphou, Neophytos
Neil, Stuart J.D.
Tedder, Richard S.
Matos, Pedro M.
Poulton, Kate
Lista, Maria Jose
Dickenson, Ruth E.
Sertkaya, Helin
Maguire, Thomas J.A.
Scourfield, Edward J.
Bowyer, Ruth C.E.
Hart, Deborah
O'Byrne, Aoife
Steel, Kathryn J.A.
Hemmings, Oliver
Rosadas, Carolina
McClure, Myra O.
Capedevilla-pujol, Joan
Wolf, Jonathan
Ourselin, Sebastien
Brown, Matthew A.
Malim, Michael H.
Spector, Tim
Steves, Claire J.
author_facet Wells, Philippa M.
Doores, Katie J.
Couvreur, Simon
Nunez, Rocio Martinez
Seow, Jeffrey
Graham, Carl
Acors, Sam
Kouphou, Neophytos
Neil, Stuart J.D.
Tedder, Richard S.
Matos, Pedro M.
Poulton, Kate
Lista, Maria Jose
Dickenson, Ruth E.
Sertkaya, Helin
Maguire, Thomas J.A.
Scourfield, Edward J.
Bowyer, Ruth C.E.
Hart, Deborah
O'Byrne, Aoife
Steel, Kathryn J.A.
Hemmings, Oliver
Rosadas, Carolina
McClure, Myra O.
Capedevilla-pujol, Joan
Wolf, Jonathan
Ourselin, Sebastien
Brown, Matthew A.
Malim, Michael H.
Spector, Tim
Steves, Claire J.
author_sort Wells, Philippa M.
collection PubMed
description BACKGROUND: Understanding of the true asymptomatic rate of infection of SARS-CoV-2 is currently limited, as is understanding of the population-based seroprevalence after the first wave of COVID-19 within the UK. The majority of data thus far come from hospitalised patients, with little focus on general population cases, or their symptoms. METHODS: We undertook enzyme linked immunosorbent assay characterisation of IgM and IgG responses against SARS-CoV-2 spike glycoprotein and nucleocapsid protein of 431 unselected general-population participants of the TwinsUK cohort from South-East England, aged 19–86 (median age 48; 85% female). 382 participants completed prospective logging of 14 COVID-19 related symptoms via the COVID Symptom Study App, allowing consideration of serology alongside individual symptoms, and a predictive algorithm for estimated COVID-19 previously modelled on PCR positive individuals from a dataset of over 2 million. FINDINGS: We demonstrated a seroprevalence of 12% (51 participants of 431). Of 48 seropositive individuals with full symptom data, nine (19%) were fully asymptomatic, and 16 (27%) were asymptomatic for core COVID-19 symptoms: fever, cough or anosmia. Specificity of anosmia for seropositivity was 95%, compared to 88% for fever cough and anosmia combined. 34 individuals in the cohort were predicted to be Covid-19 positive using the App algorithm, and of those, 18 (52%) were seropositive. INTERPRETATION: Seroprevalence amongst adults from London and South-East England was 12%, and 19% of seropositive individuals with prospective symptom logging were fully asymptomatic throughout the study. Anosmia demonstrated the highest symptom specificity for SARS-CoV-2 antibody response. FUNDING: NIHR BRC, CDRF, ZOE global LTD, RST-UKRI/MRC.
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spelling pubmed-75572992020-10-15 Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England Wells, Philippa M. Doores, Katie J. Couvreur, Simon Nunez, Rocio Martinez Seow, Jeffrey Graham, Carl Acors, Sam Kouphou, Neophytos Neil, Stuart J.D. Tedder, Richard S. Matos, Pedro M. Poulton, Kate Lista, Maria Jose Dickenson, Ruth E. Sertkaya, Helin Maguire, Thomas J.A. Scourfield, Edward J. Bowyer, Ruth C.E. Hart, Deborah O'Byrne, Aoife Steel, Kathryn J.A. Hemmings, Oliver Rosadas, Carolina McClure, Myra O. Capedevilla-pujol, Joan Wolf, Jonathan Ourselin, Sebastien Brown, Matthew A. Malim, Michael H. Spector, Tim Steves, Claire J. J Infect Article BACKGROUND: Understanding of the true asymptomatic rate of infection of SARS-CoV-2 is currently limited, as is understanding of the population-based seroprevalence after the first wave of COVID-19 within the UK. The majority of data thus far come from hospitalised patients, with little focus on general population cases, or their symptoms. METHODS: We undertook enzyme linked immunosorbent assay characterisation of IgM and IgG responses against SARS-CoV-2 spike glycoprotein and nucleocapsid protein of 431 unselected general-population participants of the TwinsUK cohort from South-East England, aged 19–86 (median age 48; 85% female). 382 participants completed prospective logging of 14 COVID-19 related symptoms via the COVID Symptom Study App, allowing consideration of serology alongside individual symptoms, and a predictive algorithm for estimated COVID-19 previously modelled on PCR positive individuals from a dataset of over 2 million. FINDINGS: We demonstrated a seroprevalence of 12% (51 participants of 431). Of 48 seropositive individuals with full symptom data, nine (19%) were fully asymptomatic, and 16 (27%) were asymptomatic for core COVID-19 symptoms: fever, cough or anosmia. Specificity of anosmia for seropositivity was 95%, compared to 88% for fever cough and anosmia combined. 34 individuals in the cohort were predicted to be Covid-19 positive using the App algorithm, and of those, 18 (52%) were seropositive. INTERPRETATION: Seroprevalence amongst adults from London and South-East England was 12%, and 19% of seropositive individuals with prospective symptom logging were fully asymptomatic throughout the study. Anosmia demonstrated the highest symptom specificity for SARS-CoV-2 antibody response. FUNDING: NIHR BRC, CDRF, ZOE global LTD, RST-UKRI/MRC. Published by Elsevier Ltd on behalf of The British Infection Association. 2020-12 2020-10-15 /pmc/articles/PMC7557299/ /pubmed/33068628 http://dx.doi.org/10.1016/j.jinf.2020.10.011 Text en © 2020 Published by Elsevier Ltd on behalf of The British Infection Association. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Wells, Philippa M.
Doores, Katie J.
Couvreur, Simon
Nunez, Rocio Martinez
Seow, Jeffrey
Graham, Carl
Acors, Sam
Kouphou, Neophytos
Neil, Stuart J.D.
Tedder, Richard S.
Matos, Pedro M.
Poulton, Kate
Lista, Maria Jose
Dickenson, Ruth E.
Sertkaya, Helin
Maguire, Thomas J.A.
Scourfield, Edward J.
Bowyer, Ruth C.E.
Hart, Deborah
O'Byrne, Aoife
Steel, Kathryn J.A.
Hemmings, Oliver
Rosadas, Carolina
McClure, Myra O.
Capedevilla-pujol, Joan
Wolf, Jonathan
Ourselin, Sebastien
Brown, Matthew A.
Malim, Michael H.
Spector, Tim
Steves, Claire J.
Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England
title Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England
title_full Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England
title_fullStr Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England
title_full_unstemmed Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England
title_short Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England
title_sort estimates of the rate of infection and asymptomatic covid-19 disease in a population sample from se england
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557299/
https://www.ncbi.nlm.nih.gov/pubmed/33068628
http://dx.doi.org/10.1016/j.jinf.2020.10.011
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