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3D-printed Bioreactors for In Vitro Modeling and Analysis

In recent years, three-dimensional (3D) printing has markedly enhanced the functionality of bioreactors by offering the capability of manufacturing intricate architectures, which changes the way of conducting in vitro biomodeling and bioanalysis. As 3D-printing technologies become increasingly matur...

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Autores principales: Priyadarshini, Balasankar Meera, Dikshit, Vishwesh, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Whioce Publishing Pte. Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557350/
https://www.ncbi.nlm.nih.gov/pubmed/33088992
http://dx.doi.org/10.18063/ijb.v6i4.267
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author Priyadarshini, Balasankar Meera
Dikshit, Vishwesh
Zhang, Yi
author_facet Priyadarshini, Balasankar Meera
Dikshit, Vishwesh
Zhang, Yi
author_sort Priyadarshini, Balasankar Meera
collection PubMed
description In recent years, three-dimensional (3D) printing has markedly enhanced the functionality of bioreactors by offering the capability of manufacturing intricate architectures, which changes the way of conducting in vitro biomodeling and bioanalysis. As 3D-printing technologies become increasingly mature, the architecture of 3D-printed bioreactors can be tailored to specific applications using different printing approaches to create an optimal environment for bioreactions. Multiple functional components have been combined into a single bioreactor fabricated by 3D-printing, and this fully functional integrated bioreactor outperforms traditional methods. Notably, several 3D-printed bioreactors systems have demonstrated improved performance in tissue engineering and drug screening due to their 3D cell culture microenvironment with precise spatial control and biological compatibility. Moreover, many microbial bioreactors have also been proposed to address the problems concerning pathogen detection, biofouling, and diagnosis of infectious diseases. This review offers a reasonably comprehensive review of 3D-printed bioreactors for in vitro biological applications. We compare the functions of bioreactors fabricated by various 3D-printing modalities and highlight the benefit of 3D-printed bioreactors compared to traditional methods.
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spelling pubmed-75573502020-10-20 3D-printed Bioreactors for In Vitro Modeling and Analysis Priyadarshini, Balasankar Meera Dikshit, Vishwesh Zhang, Yi Int J Bioprint Review Article In recent years, three-dimensional (3D) printing has markedly enhanced the functionality of bioreactors by offering the capability of manufacturing intricate architectures, which changes the way of conducting in vitro biomodeling and bioanalysis. As 3D-printing technologies become increasingly mature, the architecture of 3D-printed bioreactors can be tailored to specific applications using different printing approaches to create an optimal environment for bioreactions. Multiple functional components have been combined into a single bioreactor fabricated by 3D-printing, and this fully functional integrated bioreactor outperforms traditional methods. Notably, several 3D-printed bioreactors systems have demonstrated improved performance in tissue engineering and drug screening due to their 3D cell culture microenvironment with precise spatial control and biological compatibility. Moreover, many microbial bioreactors have also been proposed to address the problems concerning pathogen detection, biofouling, and diagnosis of infectious diseases. This review offers a reasonably comprehensive review of 3D-printed bioreactors for in vitro biological applications. We compare the functions of bioreactors fabricated by various 3D-printing modalities and highlight the benefit of 3D-printed bioreactors compared to traditional methods. Whioce Publishing Pte. Ltd. 2020-08-18 /pmc/articles/PMC7557350/ /pubmed/33088992 http://dx.doi.org/10.18063/ijb.v6i4.267 Text en Copyright: © 2020 Priyadarshini, et al. http://creativecommons.org/licenses/cc-by-nc/4.0/ This is an open-access article distributed under the terms of the Attribution-NonCommercial 4.0 International 4.0 (CC BY-NC 4.0), which permits all non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited.
spellingShingle Review Article
Priyadarshini, Balasankar Meera
Dikshit, Vishwesh
Zhang, Yi
3D-printed Bioreactors for In Vitro Modeling and Analysis
title 3D-printed Bioreactors for In Vitro Modeling and Analysis
title_full 3D-printed Bioreactors for In Vitro Modeling and Analysis
title_fullStr 3D-printed Bioreactors for In Vitro Modeling and Analysis
title_full_unstemmed 3D-printed Bioreactors for In Vitro Modeling and Analysis
title_short 3D-printed Bioreactors for In Vitro Modeling and Analysis
title_sort 3d-printed bioreactors for in vitro modeling and analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557350/
https://www.ncbi.nlm.nih.gov/pubmed/33088992
http://dx.doi.org/10.18063/ijb.v6i4.267
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