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Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease

Neuregulins (NRGs) are protein ligands that act through ErbB receptor tyrosine kinases to regulate tissue morphogenesis, plasticity, and adaptive responses to physiologic needs in multiple tissues, including the heart and circulatory system. The role of NRG/ErbB signaling in cardiovascular biology,...

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Autores principales: Geissler, Andrew, Ryzhov, Sergey, Sawyer, Douglas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557502/
https://www.ncbi.nlm.nih.gov/pubmed/33063822
http://dx.doi.org/10.1042/CS20200230
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author Geissler, Andrew
Ryzhov, Sergey
Sawyer, Douglas B.
author_facet Geissler, Andrew
Ryzhov, Sergey
Sawyer, Douglas B.
author_sort Geissler, Andrew
collection PubMed
description Neuregulins (NRGs) are protein ligands that act through ErbB receptor tyrosine kinases to regulate tissue morphogenesis, plasticity, and adaptive responses to physiologic needs in multiple tissues, including the heart and circulatory system. The role of NRG/ErbB signaling in cardiovascular biology, and how it responds to physiologic and pathologic stresses is a rapidly evolving field. While initial concepts focused on the role that NRG may play in regulating cardiac myocyte responses, including cell survival, growth, adaptation to stress, and proliferation, emerging data support a broader role for NRGs in the regulation of metabolism, inflammation, and fibrosis in response to injury. The constellation of effects modulated by NRGs may account for the findings that two distinct forms of recombinant NRG-1 have beneficial effects on cardiac function in humans with systolic heart failure. NRG-4 has recently emerged as an adipokine with similar potential to regulate cardiovascular responses to inflammation and injury. Beyond systolic heart failure, NRGs appear to have beneficial effects in diastolic heart failure, prevention of atherosclerosis, preventing adverse effects on diabetes on the heart and vasculature, including atherosclerosis, as well as the cardiac dysfunction associated with sepsis. Collectively, this literature supports the further examination of how this developmentally critical signaling system functions and how it might be leveraged to treat cardiovascular disease.
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spelling pubmed-75575022020-10-21 Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease Geissler, Andrew Ryzhov, Sergey Sawyer, Douglas B. Clin Sci (Lond) Cardiovascular System & Vascular Biology Neuregulins (NRGs) are protein ligands that act through ErbB receptor tyrosine kinases to regulate tissue morphogenesis, plasticity, and adaptive responses to physiologic needs in multiple tissues, including the heart and circulatory system. The role of NRG/ErbB signaling in cardiovascular biology, and how it responds to physiologic and pathologic stresses is a rapidly evolving field. While initial concepts focused on the role that NRG may play in regulating cardiac myocyte responses, including cell survival, growth, adaptation to stress, and proliferation, emerging data support a broader role for NRGs in the regulation of metabolism, inflammation, and fibrosis in response to injury. The constellation of effects modulated by NRGs may account for the findings that two distinct forms of recombinant NRG-1 have beneficial effects on cardiac function in humans with systolic heart failure. NRG-4 has recently emerged as an adipokine with similar potential to regulate cardiovascular responses to inflammation and injury. Beyond systolic heart failure, NRGs appear to have beneficial effects in diastolic heart failure, prevention of atherosclerosis, preventing adverse effects on diabetes on the heart and vasculature, including atherosclerosis, as well as the cardiac dysfunction associated with sepsis. Collectively, this literature supports the further examination of how this developmentally critical signaling system functions and how it might be leveraged to treat cardiovascular disease. Portland Press Ltd. 2020-10 2020-10-14 /pmc/articles/PMC7557502/ /pubmed/33063822 http://dx.doi.org/10.1042/CS20200230 Text en © 2020 The Author(s). https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).
spellingShingle Cardiovascular System & Vascular Biology
Geissler, Andrew
Ryzhov, Sergey
Sawyer, Douglas B.
Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease
title Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease
title_full Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease
title_fullStr Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease
title_full_unstemmed Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease
title_short Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease
title_sort neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease
topic Cardiovascular System & Vascular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557502/
https://www.ncbi.nlm.nih.gov/pubmed/33063822
http://dx.doi.org/10.1042/CS20200230
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