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Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents an urgent need for an effective vaccine. Molecular characterization of SARS-CoV-2 is critical to the development of effective vaccine and therapeutic strategies. In the present study, we show that the fusion o...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557813/ https://www.ncbi.nlm.nih.gov/pubmed/32872641 http://dx.doi.org/10.3390/membranes10090215 |
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author | Azad, Taha Singaravelu, Ragunath Crupi, Mathieu J.F. Jamieson, Taylor Dave, Jaahnavi Brown, Emily E.F. Rezaei, Reza Taha, Zaid Boulton, Stephen Martin, Nikolas T. Surendran, Abera Poutou, Joanna Ghahremani, Mina Nouri, Kazem Whelan, Jack T. Duong, Jessie Tucker, Sarah Diallo, Jean-Simon Bell, John C. Ilkow, Carolina S. |
author_facet | Azad, Taha Singaravelu, Ragunath Crupi, Mathieu J.F. Jamieson, Taylor Dave, Jaahnavi Brown, Emily E.F. Rezaei, Reza Taha, Zaid Boulton, Stephen Martin, Nikolas T. Surendran, Abera Poutou, Joanna Ghahremani, Mina Nouri, Kazem Whelan, Jack T. Duong, Jessie Tucker, Sarah Diallo, Jean-Simon Bell, John C. Ilkow, Carolina S. |
author_sort | Azad, Taha |
collection | PubMed |
description | The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents an urgent need for an effective vaccine. Molecular characterization of SARS-CoV-2 is critical to the development of effective vaccine and therapeutic strategies. In the present study, we show that the fusion of the SARS-CoV-2 spike protein receptor-binding domain to its transmembrane domain is sufficient to mediate trimerization. Our findings may have implications for vaccine development and therapeutic drug design strategies targeting spike trimerization. As global efforts for developing SARS-CoV-2 vaccines are rapidly underway, we believe this observation is an important consideration for identifying crucial epitopes of SARS-CoV-2. |
format | Online Article Text |
id | pubmed-7557813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75578132020-10-22 Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization Azad, Taha Singaravelu, Ragunath Crupi, Mathieu J.F. Jamieson, Taylor Dave, Jaahnavi Brown, Emily E.F. Rezaei, Reza Taha, Zaid Boulton, Stephen Martin, Nikolas T. Surendran, Abera Poutou, Joanna Ghahremani, Mina Nouri, Kazem Whelan, Jack T. Duong, Jessie Tucker, Sarah Diallo, Jean-Simon Bell, John C. Ilkow, Carolina S. Membranes (Basel) Brief Report The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents an urgent need for an effective vaccine. Molecular characterization of SARS-CoV-2 is critical to the development of effective vaccine and therapeutic strategies. In the present study, we show that the fusion of the SARS-CoV-2 spike protein receptor-binding domain to its transmembrane domain is sufficient to mediate trimerization. Our findings may have implications for vaccine development and therapeutic drug design strategies targeting spike trimerization. As global efforts for developing SARS-CoV-2 vaccines are rapidly underway, we believe this observation is an important consideration for identifying crucial epitopes of SARS-CoV-2. MDPI 2020-08-30 /pmc/articles/PMC7557813/ /pubmed/32872641 http://dx.doi.org/10.3390/membranes10090215 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Azad, Taha Singaravelu, Ragunath Crupi, Mathieu J.F. Jamieson, Taylor Dave, Jaahnavi Brown, Emily E.F. Rezaei, Reza Taha, Zaid Boulton, Stephen Martin, Nikolas T. Surendran, Abera Poutou, Joanna Ghahremani, Mina Nouri, Kazem Whelan, Jack T. Duong, Jessie Tucker, Sarah Diallo, Jean-Simon Bell, John C. Ilkow, Carolina S. Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization |
title | Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization |
title_full | Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization |
title_fullStr | Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization |
title_full_unstemmed | Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization |
title_short | Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization |
title_sort | implications for sars-cov-2 vaccine design: fusion of spike glycoprotein transmembrane domain to receptor-binding domain induces trimerization |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557813/ https://www.ncbi.nlm.nih.gov/pubmed/32872641 http://dx.doi.org/10.3390/membranes10090215 |
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