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Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents an urgent need for an effective vaccine. Molecular characterization of SARS-CoV-2 is critical to the development of effective vaccine and therapeutic strategies. In the present study, we show that the fusion o...

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Autores principales: Azad, Taha, Singaravelu, Ragunath, Crupi, Mathieu J.F., Jamieson, Taylor, Dave, Jaahnavi, Brown, Emily E.F., Rezaei, Reza, Taha, Zaid, Boulton, Stephen, Martin, Nikolas T., Surendran, Abera, Poutou, Joanna, Ghahremani, Mina, Nouri, Kazem, Whelan, Jack T., Duong, Jessie, Tucker, Sarah, Diallo, Jean-Simon, Bell, John C., Ilkow, Carolina S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557813/
https://www.ncbi.nlm.nih.gov/pubmed/32872641
http://dx.doi.org/10.3390/membranes10090215
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author Azad, Taha
Singaravelu, Ragunath
Crupi, Mathieu J.F.
Jamieson, Taylor
Dave, Jaahnavi
Brown, Emily E.F.
Rezaei, Reza
Taha, Zaid
Boulton, Stephen
Martin, Nikolas T.
Surendran, Abera
Poutou, Joanna
Ghahremani, Mina
Nouri, Kazem
Whelan, Jack T.
Duong, Jessie
Tucker, Sarah
Diallo, Jean-Simon
Bell, John C.
Ilkow, Carolina S.
author_facet Azad, Taha
Singaravelu, Ragunath
Crupi, Mathieu J.F.
Jamieson, Taylor
Dave, Jaahnavi
Brown, Emily E.F.
Rezaei, Reza
Taha, Zaid
Boulton, Stephen
Martin, Nikolas T.
Surendran, Abera
Poutou, Joanna
Ghahremani, Mina
Nouri, Kazem
Whelan, Jack T.
Duong, Jessie
Tucker, Sarah
Diallo, Jean-Simon
Bell, John C.
Ilkow, Carolina S.
author_sort Azad, Taha
collection PubMed
description The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents an urgent need for an effective vaccine. Molecular characterization of SARS-CoV-2 is critical to the development of effective vaccine and therapeutic strategies. In the present study, we show that the fusion of the SARS-CoV-2 spike protein receptor-binding domain to its transmembrane domain is sufficient to mediate trimerization. Our findings may have implications for vaccine development and therapeutic drug design strategies targeting spike trimerization. As global efforts for developing SARS-CoV-2 vaccines are rapidly underway, we believe this observation is an important consideration for identifying crucial epitopes of SARS-CoV-2.
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spelling pubmed-75578132020-10-22 Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization Azad, Taha Singaravelu, Ragunath Crupi, Mathieu J.F. Jamieson, Taylor Dave, Jaahnavi Brown, Emily E.F. Rezaei, Reza Taha, Zaid Boulton, Stephen Martin, Nikolas T. Surendran, Abera Poutou, Joanna Ghahremani, Mina Nouri, Kazem Whelan, Jack T. Duong, Jessie Tucker, Sarah Diallo, Jean-Simon Bell, John C. Ilkow, Carolina S. Membranes (Basel) Brief Report The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents an urgent need for an effective vaccine. Molecular characterization of SARS-CoV-2 is critical to the development of effective vaccine and therapeutic strategies. In the present study, we show that the fusion of the SARS-CoV-2 spike protein receptor-binding domain to its transmembrane domain is sufficient to mediate trimerization. Our findings may have implications for vaccine development and therapeutic drug design strategies targeting spike trimerization. As global efforts for developing SARS-CoV-2 vaccines are rapidly underway, we believe this observation is an important consideration for identifying crucial epitopes of SARS-CoV-2. MDPI 2020-08-30 /pmc/articles/PMC7557813/ /pubmed/32872641 http://dx.doi.org/10.3390/membranes10090215 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Azad, Taha
Singaravelu, Ragunath
Crupi, Mathieu J.F.
Jamieson, Taylor
Dave, Jaahnavi
Brown, Emily E.F.
Rezaei, Reza
Taha, Zaid
Boulton, Stephen
Martin, Nikolas T.
Surendran, Abera
Poutou, Joanna
Ghahremani, Mina
Nouri, Kazem
Whelan, Jack T.
Duong, Jessie
Tucker, Sarah
Diallo, Jean-Simon
Bell, John C.
Ilkow, Carolina S.
Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization
title Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization
title_full Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization
title_fullStr Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization
title_full_unstemmed Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization
title_short Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization
title_sort implications for sars-cov-2 vaccine design: fusion of spike glycoprotein transmembrane domain to receptor-binding domain induces trimerization
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557813/
https://www.ncbi.nlm.nih.gov/pubmed/32872641
http://dx.doi.org/10.3390/membranes10090215
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