Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal

We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCB...

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Autores principales: Harrison, Paul J., Tunbridge, Elizabeth M., Dolphin, Annette C., Hall, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Reappraisal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557861/
https://www.ncbi.nlm.nih.gov/pubmed/31230606
http://dx.doi.org/10.1192/bjp.2019.157
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author Harrison, Paul J.
Tunbridge, Elizabeth M.
Dolphin, Annette C.
Hall, Jeremy
author_facet Harrison, Paul J.
Tunbridge, Elizabeth M.
Dolphin, Annette C.
Hall, Jeremy
author_sort Harrison, Paul J.
collection PubMed
description We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications.
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spelling pubmed-75578612020-10-26 Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal Harrison, Paul J. Tunbridge, Elizabeth M. Dolphin, Annette C. Hall, Jeremy Br J Psychiatry Reappraisal We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications. Cambridge University Press 2020-05 2019-06-24 /pmc/articles/PMC7557861/ /pubmed/31230606 http://dx.doi.org/10.1192/bjp.2019.157 Text en © The Royal College of Psychiatrists 2019 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reappraisal
Harrison, Paul J.
Tunbridge, Elizabeth M.
Dolphin, Annette C.
Hall, Jeremy
Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal
title Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal
title_full Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal
title_fullStr Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal
title_full_unstemmed Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal
title_short Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal
title_sort voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal
topic Reappraisal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557861/
https://www.ncbi.nlm.nih.gov/pubmed/31230606
http://dx.doi.org/10.1192/bjp.2019.157
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