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Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component

Large cell neuroendocrine carcinoma (LCNC) is one of the rarest types of bladder cancer occurring in <1%. Either pure or mixed with another component, it remains one of the most aggressive types of bladder cancer. We report a case of LCNC of the bladder with an adenocarcinomatous component. The p...

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Autores principales: Halabi, Rami, Abdessater, Maher, Boustany, Johnny, Kanbar, Anthony, Akl, Halim, El Khoury, Joey, El Hachem, Charbel, El Khoury, Raghid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557901/
https://www.ncbi.nlm.nih.gov/pubmed/33083089
http://dx.doi.org/10.1155/2020/8827646
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author Halabi, Rami
Abdessater, Maher
Boustany, Johnny
Kanbar, Anthony
Akl, Halim
El Khoury, Joey
El Hachem, Charbel
El Khoury, Raghid
author_facet Halabi, Rami
Abdessater, Maher
Boustany, Johnny
Kanbar, Anthony
Akl, Halim
El Khoury, Joey
El Hachem, Charbel
El Khoury, Raghid
author_sort Halabi, Rami
collection PubMed
description Large cell neuroendocrine carcinoma (LCNC) is one of the rarest types of bladder cancer occurring in <1%. Either pure or mixed with another component, it remains one of the most aggressive types of bladder cancer. We report a case of LCNC of the bladder with an adenocarcinomatous component. The patient was a 64-year-old smoker male, who presented for the first time with dysuria and hematuria. A bladder tumor invading the anterior and right lateral bladder walls was discovered, without any secondary localizations. Tumor biopsy showed an LCNC with adenocarcinomatous components. The patient was treated by recurrent tumor resections, chemotherapy, and radiotherapy. No improvement was noted despite close follow-up and adequate treatment. Neuroendocrine bladder tumor is known to have an aggressive, rapid, and disadvantageous evolution. Multiple case reports were published so far, and a recent review was conducted in March 2020 by Sanguedolce et al. (2020). More cases are needed to establish the best management plan for this type of tumor.
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spelling pubmed-75579012020-10-19 Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component Halabi, Rami Abdessater, Maher Boustany, Johnny Kanbar, Anthony Akl, Halim El Khoury, Joey El Hachem, Charbel El Khoury, Raghid Case Rep Urol Case Report Large cell neuroendocrine carcinoma (LCNC) is one of the rarest types of bladder cancer occurring in <1%. Either pure or mixed with another component, it remains one of the most aggressive types of bladder cancer. We report a case of LCNC of the bladder with an adenocarcinomatous component. The patient was a 64-year-old smoker male, who presented for the first time with dysuria and hematuria. A bladder tumor invading the anterior and right lateral bladder walls was discovered, without any secondary localizations. Tumor biopsy showed an LCNC with adenocarcinomatous components. The patient was treated by recurrent tumor resections, chemotherapy, and radiotherapy. No improvement was noted despite close follow-up and adequate treatment. Neuroendocrine bladder tumor is known to have an aggressive, rapid, and disadvantageous evolution. Multiple case reports were published so far, and a recent review was conducted in March 2020 by Sanguedolce et al. (2020). More cases are needed to establish the best management plan for this type of tumor. Hindawi 2020-10-05 /pmc/articles/PMC7557901/ /pubmed/33083089 http://dx.doi.org/10.1155/2020/8827646 Text en Copyright © 2020 Rami Halabi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Halabi, Rami
Abdessater, Maher
Boustany, Johnny
Kanbar, Anthony
Akl, Halim
El Khoury, Joey
El Hachem, Charbel
El Khoury, Raghid
Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component
title Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component
title_full Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component
title_fullStr Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component
title_full_unstemmed Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component
title_short Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component
title_sort large cell neuroendocrine carcinoma of the bladder with adenocarcinomatous component
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557901/
https://www.ncbi.nlm.nih.gov/pubmed/33083089
http://dx.doi.org/10.1155/2020/8827646
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