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Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component
Large cell neuroendocrine carcinoma (LCNC) is one of the rarest types of bladder cancer occurring in <1%. Either pure or mixed with another component, it remains one of the most aggressive types of bladder cancer. We report a case of LCNC of the bladder with an adenocarcinomatous component. The p...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557901/ https://www.ncbi.nlm.nih.gov/pubmed/33083089 http://dx.doi.org/10.1155/2020/8827646 |
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author | Halabi, Rami Abdessater, Maher Boustany, Johnny Kanbar, Anthony Akl, Halim El Khoury, Joey El Hachem, Charbel El Khoury, Raghid |
author_facet | Halabi, Rami Abdessater, Maher Boustany, Johnny Kanbar, Anthony Akl, Halim El Khoury, Joey El Hachem, Charbel El Khoury, Raghid |
author_sort | Halabi, Rami |
collection | PubMed |
description | Large cell neuroendocrine carcinoma (LCNC) is one of the rarest types of bladder cancer occurring in <1%. Either pure or mixed with another component, it remains one of the most aggressive types of bladder cancer. We report a case of LCNC of the bladder with an adenocarcinomatous component. The patient was a 64-year-old smoker male, who presented for the first time with dysuria and hematuria. A bladder tumor invading the anterior and right lateral bladder walls was discovered, without any secondary localizations. Tumor biopsy showed an LCNC with adenocarcinomatous components. The patient was treated by recurrent tumor resections, chemotherapy, and radiotherapy. No improvement was noted despite close follow-up and adequate treatment. Neuroendocrine bladder tumor is known to have an aggressive, rapid, and disadvantageous evolution. Multiple case reports were published so far, and a recent review was conducted in March 2020 by Sanguedolce et al. (2020). More cases are needed to establish the best management plan for this type of tumor. |
format | Online Article Text |
id | pubmed-7557901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-75579012020-10-19 Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component Halabi, Rami Abdessater, Maher Boustany, Johnny Kanbar, Anthony Akl, Halim El Khoury, Joey El Hachem, Charbel El Khoury, Raghid Case Rep Urol Case Report Large cell neuroendocrine carcinoma (LCNC) is one of the rarest types of bladder cancer occurring in <1%. Either pure or mixed with another component, it remains one of the most aggressive types of bladder cancer. We report a case of LCNC of the bladder with an adenocarcinomatous component. The patient was a 64-year-old smoker male, who presented for the first time with dysuria and hematuria. A bladder tumor invading the anterior and right lateral bladder walls was discovered, without any secondary localizations. Tumor biopsy showed an LCNC with adenocarcinomatous components. The patient was treated by recurrent tumor resections, chemotherapy, and radiotherapy. No improvement was noted despite close follow-up and adequate treatment. Neuroendocrine bladder tumor is known to have an aggressive, rapid, and disadvantageous evolution. Multiple case reports were published so far, and a recent review was conducted in March 2020 by Sanguedolce et al. (2020). More cases are needed to establish the best management plan for this type of tumor. Hindawi 2020-10-05 /pmc/articles/PMC7557901/ /pubmed/33083089 http://dx.doi.org/10.1155/2020/8827646 Text en Copyright © 2020 Rami Halabi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Halabi, Rami Abdessater, Maher Boustany, Johnny Kanbar, Anthony Akl, Halim El Khoury, Joey El Hachem, Charbel El Khoury, Raghid Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component |
title | Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component |
title_full | Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component |
title_fullStr | Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component |
title_full_unstemmed | Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component |
title_short | Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component |
title_sort | large cell neuroendocrine carcinoma of the bladder with adenocarcinomatous component |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557901/ https://www.ncbi.nlm.nih.gov/pubmed/33083089 http://dx.doi.org/10.1155/2020/8827646 |
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