Cargando…

Characterization of Commercial Metal Oxide Nanomaterials: Crystalline Phase, Particle Size and Specific Surface Area

Physical chemical characterization of nanomaterials is critical to assessing quality control during production, evaluating the impact of material properties on human health and the environment, and developing regulatory frameworks for their use. We have investigated a set of 29 nanomaterials from fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Bushell, Michael, Beauchemin, Suzanne, Kunc, Filip, Gardner, David, Ovens, Jeffrey, Toll, Floyd, Kennedy, David, Nguyen, Kathy, Vladisavljevic, Djordje, Rasmussen, Pat E., Johnston, Linda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558088/
https://www.ncbi.nlm.nih.gov/pubmed/32932807
http://dx.doi.org/10.3390/nano10091812
_version_ 1783594561895923712
author Bushell, Michael
Beauchemin, Suzanne
Kunc, Filip
Gardner, David
Ovens, Jeffrey
Toll, Floyd
Kennedy, David
Nguyen, Kathy
Vladisavljevic, Djordje
Rasmussen, Pat E.
Johnston, Linda J.
author_facet Bushell, Michael
Beauchemin, Suzanne
Kunc, Filip
Gardner, David
Ovens, Jeffrey
Toll, Floyd
Kennedy, David
Nguyen, Kathy
Vladisavljevic, Djordje
Rasmussen, Pat E.
Johnston, Linda J.
author_sort Bushell, Michael
collection PubMed
description Physical chemical characterization of nanomaterials is critical to assessing quality control during production, evaluating the impact of material properties on human health and the environment, and developing regulatory frameworks for their use. We have investigated a set of 29 nanomaterials from four metal oxide families (aluminum, copper, titanium and zinc) with a focus on the measurands that are important for the basic characterization of dry nanomaterials and the determination of the dose metrics for nanotoxicology. These include crystalline phase and crystallite size, measured by powder X-ray diffraction, particle shape and size distributions from transmission electron microscopy, and specific surface area, measured by gas adsorption. The results are compared to the nominal data provided by the manufacturer, where available. While the crystalline phase data are generally reliable, data on minor components that may impact toxicity is often lacking. The crystal and particle size data highlight the issues in obtaining size measurements of materials with broad size distributions and significant levels of aggregation, and indicate that reliance on nominal values provided by the manufacturer is frequently inadequate for toxicological studies aimed at identifying differences between nanoforms. The data will be used for the development of models and strategies for grouping and read-across to support regulatory human health and environmental assessments of metal oxide nanomaterials.
format Online
Article
Text
id pubmed-7558088
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75580882020-10-22 Characterization of Commercial Metal Oxide Nanomaterials: Crystalline Phase, Particle Size and Specific Surface Area Bushell, Michael Beauchemin, Suzanne Kunc, Filip Gardner, David Ovens, Jeffrey Toll, Floyd Kennedy, David Nguyen, Kathy Vladisavljevic, Djordje Rasmussen, Pat E. Johnston, Linda J. Nanomaterials (Basel) Article Physical chemical characterization of nanomaterials is critical to assessing quality control during production, evaluating the impact of material properties on human health and the environment, and developing regulatory frameworks for their use. We have investigated a set of 29 nanomaterials from four metal oxide families (aluminum, copper, titanium and zinc) with a focus on the measurands that are important for the basic characterization of dry nanomaterials and the determination of the dose metrics for nanotoxicology. These include crystalline phase and crystallite size, measured by powder X-ray diffraction, particle shape and size distributions from transmission electron microscopy, and specific surface area, measured by gas adsorption. The results are compared to the nominal data provided by the manufacturer, where available. While the crystalline phase data are generally reliable, data on minor components that may impact toxicity is often lacking. The crystal and particle size data highlight the issues in obtaining size measurements of materials with broad size distributions and significant levels of aggregation, and indicate that reliance on nominal values provided by the manufacturer is frequently inadequate for toxicological studies aimed at identifying differences between nanoforms. The data will be used for the development of models and strategies for grouping and read-across to support regulatory human health and environmental assessments of metal oxide nanomaterials. MDPI 2020-09-11 /pmc/articles/PMC7558088/ /pubmed/32932807 http://dx.doi.org/10.3390/nano10091812 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bushell, Michael
Beauchemin, Suzanne
Kunc, Filip
Gardner, David
Ovens, Jeffrey
Toll, Floyd
Kennedy, David
Nguyen, Kathy
Vladisavljevic, Djordje
Rasmussen, Pat E.
Johnston, Linda J.
Characterization of Commercial Metal Oxide Nanomaterials: Crystalline Phase, Particle Size and Specific Surface Area
title Characterization of Commercial Metal Oxide Nanomaterials: Crystalline Phase, Particle Size and Specific Surface Area
title_full Characterization of Commercial Metal Oxide Nanomaterials: Crystalline Phase, Particle Size and Specific Surface Area
title_fullStr Characterization of Commercial Metal Oxide Nanomaterials: Crystalline Phase, Particle Size and Specific Surface Area
title_full_unstemmed Characterization of Commercial Metal Oxide Nanomaterials: Crystalline Phase, Particle Size and Specific Surface Area
title_short Characterization of Commercial Metal Oxide Nanomaterials: Crystalline Phase, Particle Size and Specific Surface Area
title_sort characterization of commercial metal oxide nanomaterials: crystalline phase, particle size and specific surface area
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558088/
https://www.ncbi.nlm.nih.gov/pubmed/32932807
http://dx.doi.org/10.3390/nano10091812
work_keys_str_mv AT bushellmichael characterizationofcommercialmetaloxidenanomaterialscrystallinephaseparticlesizeandspecificsurfacearea
AT beaucheminsuzanne characterizationofcommercialmetaloxidenanomaterialscrystallinephaseparticlesizeandspecificsurfacearea
AT kuncfilip characterizationofcommercialmetaloxidenanomaterialscrystallinephaseparticlesizeandspecificsurfacearea
AT gardnerdavid characterizationofcommercialmetaloxidenanomaterialscrystallinephaseparticlesizeandspecificsurfacearea
AT ovensjeffrey characterizationofcommercialmetaloxidenanomaterialscrystallinephaseparticlesizeandspecificsurfacearea
AT tollfloyd characterizationofcommercialmetaloxidenanomaterialscrystallinephaseparticlesizeandspecificsurfacearea
AT kennedydavid characterizationofcommercialmetaloxidenanomaterialscrystallinephaseparticlesizeandspecificsurfacearea
AT nguyenkathy characterizationofcommercialmetaloxidenanomaterialscrystallinephaseparticlesizeandspecificsurfacearea
AT vladisavljevicdjordje characterizationofcommercialmetaloxidenanomaterialscrystallinephaseparticlesizeandspecificsurfacearea
AT rasmussenpate characterizationofcommercialmetaloxidenanomaterialscrystallinephaseparticlesizeandspecificsurfacearea
AT johnstonlindaj characterizationofcommercialmetaloxidenanomaterialscrystallinephaseparticlesizeandspecificsurfacearea