Cargando…

Exploration of Chemical Diversity and Antitrypanosomal Activity of Some Red Sea-Derived Actinomycetes Using the OSMAC Approach Supported by LC-MS-Based Metabolomics and Molecular Modelling

In the present study, we investigated the actinomycetes associated with the Red Sea-derived soft coral Sarcophyton glaucum in terms of biological and chemical diversity. Three strains were cultivated and identified to be members of genera Micromonospora, Streptomyces, and Nocardiopsis; out of them,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gamaleldin, Noha M., Bakeer, Walid, Sayed, Ahmed M., Shamikh, Yara I., El-Gendy, Ahmed O., Hassan, Hossam M., Horn, Hannes, Abdelmohsen, Usama Ramadan, Hozzein, Wael N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558093/ https://www.ncbi.nlm.nih.gov/pubmed/32971728 http://dx.doi.org/10.3390/antibiotics9090629

Ejemplares similares

Actinomycetes from the Red Sea Sponge Coscinoderma mathewsi: Isolation, Diversity, and Potential for Bioactive Compounds Discovery
por: Shamikh, Yara I., et al.
Publicado: (2020)

Metabolomic profiling, biological evaluation of Aspergillus awamori, the river Nile-derived fungus using epigenetic and OSMAC approaches
por: Lotfy, Momen M., et al.
Publicado: (2021)

A metabolomic approach to target antimalarial metabolites in the Artemisia annua fungal endophytes
por: Alhadrami, Hani A., et al.
Publicado: (2021)

Actinomycetes from Red Sea Sponges: Sources for Chemical and Phylogenetic Diversity
por: Abdelmohsen, Usama Ramadan, et al.
Publicado: (2014)

Microbial Natural Products as Potential Inhibitors of SARS-CoV-2 Main Protease (M(pro))
por: Sayed, Ahmed M., et al.
Publicado: (2020)

Draft Genome Sequence of the Antitrypanosomally Active Sponge-Associated Bacterium Actinokineospora sp. Strain EG49
por: Harjes, Janno, et al.
Publicado: (2014)

Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges
por: Cheng, Cheng, et al.
Publicado: (2015)

Elicitation for activation of the actinomycete genome's cryptic secondary metabolite gene clusters
por: El-Hawary, Seham S., et al.
Publicado: (2023)

Metabolomic Profiling, In Vitro Antimalarial Investigation and In Silico Modeling of the Marine Actinobacterium Strain Rhodococcus sp. UR111 Associated with the Soft Coral Nephthea sp.
por: Gamaleldin, Noha M., et al.
Publicado: (2022)

Bioassay- and metabolomics-guided screening of bioactive soil actinomycetes from the ancient city of Ihnasia, Egypt
por: Sebak, Mohamed, et al.
Publicado: (2019)

New Pim-1 Kinase Inhibitor From the Co-culture of Two Sponge-Associated Actinomycetes
por: El-Hawary, Seham S., et al.
Publicado: (2018)

Discovery of Two Brominated Oxindole Alkaloids as Staphylococcal DNA Gyrase and Pyruvate Kinase Inhibitors via Inverse Virtual Screening
por: Sayed, Ahmed M., et al.
Publicado: (2020)

Correction: Bioassay- and metabolomics-guided screening of bioactive soil actinomycetes from the ancient city of Ihnasia, Egypt
por: Sebak, Mohamed, et al.
Publicado: (2020)

Actinomycetes Enrich Soil Rhizosphere and Improve Seed Quality as well as Productivity of Legumes by Boosting Nitrogen Availability and Metabolism
por: AbdElgawad, Hamada, et al.
Publicado: (2020)

A Glossary for Chemical Approaches towards Unlocking the Trove of Metabolic Treasures in Actinomycetes
por: Zhang, Jianye, et al.
Publicado: (2021)

Isolation, Phylogenetic Analysis and Anti-infective Activity Screening of Marine Sponge-Associated Actinomycetes
por: Abdelmohsen, Usama Ramadan, et al.
Publicado: (2010)

Induction of Antibacterial Metabolites by Co-Cultivation of Two Red-Sea-Sponge-Associated Actinomycetes Micromonospora sp. UR56 and Actinokinespora sp. EG49
por: S. Hifnawy, Mohamed, et al.
Publicado: (2020)

Dereplication Strategies for Targeted Isolation of New Antitrypanosomal Actinosporins A and B from a Marine Sponge Associated-Actinokineospora sp. EG49
por: Abdelmohsen, Usama Ramadan, et al.
Publicado: (2014)

Application of metabolomics and molecular networking in investigating the chemical profile and antitrypanosomal activity of British bluebells (Hyacinthoides non-scripta)
por: Raheem, Dotsha J., et al.
Publicado: (2019)

Anti-cancer and antimicrobial potential of five soil Streptomycetes: a metabolomics-based study
por: Osama, Nada, et al.
Publicado: (2022)

Cnicin as an Anti-SARS-CoV-2: An Integrated In Silico and In Vitro Approach for the Rapid Identification of Potential COVID-19 Therapeutics
por: Alhadrami, Hani A., et al.
Publicado: (2021)

Mining Genomes of Three Marine Sponge-Associated Actinobacterial Isolates for Secondary Metabolism
por: Horn, Hannes, et al.
Publicado: (2015)

Production of Induced Secondary Metabolites by a Co-Culture of Sponge-Associated Actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163
por: Dashti, Yousef, et al.
Publicado: (2014)

Chemical Profiling and Biological Screening of Some River Nile Derived-Microorganisms
por: Lotfy, Momen M., et al.
Publicado: (2019)

OSMAC Approach and Cocultivation for the Induction of Secondary Metabolism of the Fungus Pleotrichocladium opacum
por: Rodríguez Martín-Aragón, Víctor, et al.
Publicado: (2023)

Saccharomonosporine A inspiration; synthesis of potent analogues as potential PIM kinase inhibitors
por: AboulMagd, Asmaa M., et al.
Publicado: (2020)

The Actinomycetes
por: Cutter, V. M.
Publicado: (1951)

Extending the “One Strain Many Compounds” (OSMAC) Principle to Marine Microorganisms
por: Romano, Stefano, et al.
Publicado: (2018)

Antitrypanosomal properties of Anogeissus leiocarpa extracts and their inhibitory effect on trypanosome alternative oxidase
por: Tauheed, Abdullah M., et al.
Publicado: (2022)

Antitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones from Polygonum salicifolium
por: Zheoat, Ahmed M., et al.
Publicado: (2021)

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
por: Zhang, Ning, et al.
Publicado: (2018)

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals
por: Wall, Richard J., et al.
Publicado: (2018)

Insights into antitrypanosomal drug mode-of-action from cytology-based profiling
por: Thomas, James A., et al.
Publicado: (2018)

Histone deacetylases as targets for antitrypanosomal drugs
por: Zuma, Aline A, et al.
Publicado: (2018)

Antitrypanosomal butanolides from Aiouea trinervis
por: Nunes, Felipe Oliveira, et al.
Publicado: (2020)

Enantiospecific antitrypanosomal in vitro activity of eflornithine
por: Boberg, Mikael, et al.
Publicado: (2021)

Novel Antiviral and Antibacterial Activities of Hibiscus schizopetalus
por: El-Shiekh, Riham A., et al.
Publicado: (2020)

Allelopathic Polyketides from an Endolichenic Fungus Myxotrichum SP. by Using OSMAC Strategy
por: Yuan, Chao, et al.
Publicado: (2016)

Cryptic Metabolites from Marine-Derived Microorganisms Using OSMAC and Epigenetic Approaches
por: Pinedo-Rivilla, Cristina, et al.
Publicado: (2022)

Metabolomic Strategies to Improve Chemical Information from OSMAC Studies of Endophytic Fungi
por: da Silva, Fernanda Motta Ribeiro, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_okeip82ev28kronekk7a0u2m81