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The Prescription of Vitamin K Antagonists in a Very Old Population: A Cross-Sectional Study of 8696 Ambulatory Subjects Aged Over 85 Years

We compared very elderly people taking vitamin K antagonists (VKA) and those not taking VKA (noVKA). Individuals were included in the noVKA group if there was no VKA on their reimbursed prescriptions during the study period. We also compared three subgroups, constituted by VKA type (fluindione, warf...

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Autores principales: Manckoundia, Patrick, Rosay, Clémentine, Menu, Didier, Nuss, Valentine, Mihai, Anca-Maria, Vovelle, Jérémie, Nuémi, Gilles, d’Athis, Philippe, Putot, Alain, Barben, Jérémy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558265/
https://www.ncbi.nlm.nih.gov/pubmed/32937847
http://dx.doi.org/10.3390/ijerph17186685
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author Manckoundia, Patrick
Rosay, Clémentine
Menu, Didier
Nuss, Valentine
Mihai, Anca-Maria
Vovelle, Jérémie
Nuémi, Gilles
d’Athis, Philippe
Putot, Alain
Barben, Jérémy
author_facet Manckoundia, Patrick
Rosay, Clémentine
Menu, Didier
Nuss, Valentine
Mihai, Anca-Maria
Vovelle, Jérémie
Nuémi, Gilles
d’Athis, Philippe
Putot, Alain
Barben, Jérémy
author_sort Manckoundia, Patrick
collection PubMed
description We compared very elderly people taking vitamin K antagonists (VKA) and those not taking VKA (noVKA). Individuals were included in the noVKA group if there was no VKA on their reimbursed prescriptions during the study period. We also compared three subgroups, constituted by VKA type (fluindione, warfarin, or acenocoumarol). We included individuals aged over 85 years, affiliated to Mutualité Sociale Agricole of Burgundy, who were refunded for prescribed VKA in September 2017. The VKA and noVKA groups were compared in terms of demographic conditions, registered chronic diseases (RCD), number of drugs per prescription and cardiovascular medications. The three VKA subgroups were compared for the same items plus laboratory monitoring, novel and refill VKA prescriptions, and prescriber specialty. Of the 8696 included individuals, 1157 (13.30%) were prescribed VKA. Mean age was 90 years. The noVKA group had fewer women (53.67 vs 66.08%), more RCD (93.43 vs. 71.96%) and more drugs per prescription (6.65 vs. 5.18) than the VKA group (all p < 0.01). Except for direct oral anticoagulants and platelet aggregation inhibitors, the VKA group took significantly more cardiovascular medications. The most commonly prescribed VKA was fluindione (59.46%). Mean age was higher in the warfarin (90.42) than in the acenocoumarol (89.83) or fluindione (89.71) subgroups (p < 0.01). No differences were observed for sex (women were predominant) or RCD. 13% of subjects in this population had a VKA prescription. Fluindione was the most commonly prescribed VKA.
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spelling pubmed-75582652020-10-29 The Prescription of Vitamin K Antagonists in a Very Old Population: A Cross-Sectional Study of 8696 Ambulatory Subjects Aged Over 85 Years Manckoundia, Patrick Rosay, Clémentine Menu, Didier Nuss, Valentine Mihai, Anca-Maria Vovelle, Jérémie Nuémi, Gilles d’Athis, Philippe Putot, Alain Barben, Jérémy Int J Environ Res Public Health Article We compared very elderly people taking vitamin K antagonists (VKA) and those not taking VKA (noVKA). Individuals were included in the noVKA group if there was no VKA on their reimbursed prescriptions during the study period. We also compared three subgroups, constituted by VKA type (fluindione, warfarin, or acenocoumarol). We included individuals aged over 85 years, affiliated to Mutualité Sociale Agricole of Burgundy, who were refunded for prescribed VKA in September 2017. The VKA and noVKA groups were compared in terms of demographic conditions, registered chronic diseases (RCD), number of drugs per prescription and cardiovascular medications. The three VKA subgroups were compared for the same items plus laboratory monitoring, novel and refill VKA prescriptions, and prescriber specialty. Of the 8696 included individuals, 1157 (13.30%) were prescribed VKA. Mean age was 90 years. The noVKA group had fewer women (53.67 vs 66.08%), more RCD (93.43 vs. 71.96%) and more drugs per prescription (6.65 vs. 5.18) than the VKA group (all p < 0.01). Except for direct oral anticoagulants and platelet aggregation inhibitors, the VKA group took significantly more cardiovascular medications. The most commonly prescribed VKA was fluindione (59.46%). Mean age was higher in the warfarin (90.42) than in the acenocoumarol (89.83) or fluindione (89.71) subgroups (p < 0.01). No differences were observed for sex (women were predominant) or RCD. 13% of subjects in this population had a VKA prescription. Fluindione was the most commonly prescribed VKA. MDPI 2020-09-14 2020-09 /pmc/articles/PMC7558265/ /pubmed/32937847 http://dx.doi.org/10.3390/ijerph17186685 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Manckoundia, Patrick
Rosay, Clémentine
Menu, Didier
Nuss, Valentine
Mihai, Anca-Maria
Vovelle, Jérémie
Nuémi, Gilles
d’Athis, Philippe
Putot, Alain
Barben, Jérémy
The Prescription of Vitamin K Antagonists in a Very Old Population: A Cross-Sectional Study of 8696 Ambulatory Subjects Aged Over 85 Years
title The Prescription of Vitamin K Antagonists in a Very Old Population: A Cross-Sectional Study of 8696 Ambulatory Subjects Aged Over 85 Years
title_full The Prescription of Vitamin K Antagonists in a Very Old Population: A Cross-Sectional Study of 8696 Ambulatory Subjects Aged Over 85 Years
title_fullStr The Prescription of Vitamin K Antagonists in a Very Old Population: A Cross-Sectional Study of 8696 Ambulatory Subjects Aged Over 85 Years
title_full_unstemmed The Prescription of Vitamin K Antagonists in a Very Old Population: A Cross-Sectional Study of 8696 Ambulatory Subjects Aged Over 85 Years
title_short The Prescription of Vitamin K Antagonists in a Very Old Population: A Cross-Sectional Study of 8696 Ambulatory Subjects Aged Over 85 Years
title_sort prescription of vitamin k antagonists in a very old population: a cross-sectional study of 8696 ambulatory subjects aged over 85 years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558265/
https://www.ncbi.nlm.nih.gov/pubmed/32937847
http://dx.doi.org/10.3390/ijerph17186685
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