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Reliability of Screening Methods to Diagnose Oral Dryness and Evaluate Saliva Secretion

In this study, we evaluated the reliability and reproducibility of widely implemented salivary flow rate and oral dryness tests. In experiment 1, twenty young and healthy Japanese participants volunteered to participate. For each participant, the oral moisture (OM) level, unstimulated whole saliva v...

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Autores principales: Goto, Takaharu, Kishimoto, Takahiro, Iwawaki, Yuki, Fujimoto, Keiko, Ishida, Yuichi, Watanabe, Megumi, Nagao, Kan, Ichikawa, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558334/
https://www.ncbi.nlm.nih.gov/pubmed/32887247
http://dx.doi.org/10.3390/dj8030102
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author Goto, Takaharu
Kishimoto, Takahiro
Iwawaki, Yuki
Fujimoto, Keiko
Ishida, Yuichi
Watanabe, Megumi
Nagao, Kan
Ichikawa, Tetsuo
author_facet Goto, Takaharu
Kishimoto, Takahiro
Iwawaki, Yuki
Fujimoto, Keiko
Ishida, Yuichi
Watanabe, Megumi
Nagao, Kan
Ichikawa, Tetsuo
author_sort Goto, Takaharu
collection PubMed
description In this study, we evaluated the reliability and reproducibility of widely implemented salivary flow rate and oral dryness tests. In experiment 1, twenty young and healthy Japanese participants volunteered to participate. For each participant, the oral moisture (OM) level, unstimulated whole saliva volume (U-WSV), and stimulated whole saliva volume (S-WSV) were measured at the same time on two separate days. In experiment 2, twenty-seven patients who were over 65 years of age volunteered to participate. The OM level and U-WSV were measured at the same time on two separate days. In Experiment 1, the intra-class correlation coefficients (ICCs) corresponding to the S-WSV, U-WSV, and OM level were 0.23, 0.28, and 0.16, respectively, for the young participants. In Experiment 2, the ICCs corresponding to the U-WSV/spitting and OM level were 0.83 and 0.12, respectively, for the older participants. The results of Bland–Altman analysis confirmed the absence of systematic error, with the exception of the OM level results in Experiment 2, which indicated systematic bias. In conclusion, we believe that there is currently no consistent and reliable screening test for assessing salivary flow rate and oral dryness, although the spitting test was determined to be highly reliable.
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spelling pubmed-75583342020-10-22 Reliability of Screening Methods to Diagnose Oral Dryness and Evaluate Saliva Secretion Goto, Takaharu Kishimoto, Takahiro Iwawaki, Yuki Fujimoto, Keiko Ishida, Yuichi Watanabe, Megumi Nagao, Kan Ichikawa, Tetsuo Dent J (Basel) Article In this study, we evaluated the reliability and reproducibility of widely implemented salivary flow rate and oral dryness tests. In experiment 1, twenty young and healthy Japanese participants volunteered to participate. For each participant, the oral moisture (OM) level, unstimulated whole saliva volume (U-WSV), and stimulated whole saliva volume (S-WSV) were measured at the same time on two separate days. In experiment 2, twenty-seven patients who were over 65 years of age volunteered to participate. The OM level and U-WSV were measured at the same time on two separate days. In Experiment 1, the intra-class correlation coefficients (ICCs) corresponding to the S-WSV, U-WSV, and OM level were 0.23, 0.28, and 0.16, respectively, for the young participants. In Experiment 2, the ICCs corresponding to the U-WSV/spitting and OM level were 0.83 and 0.12, respectively, for the older participants. The results of Bland–Altman analysis confirmed the absence of systematic error, with the exception of the OM level results in Experiment 2, which indicated systematic bias. In conclusion, we believe that there is currently no consistent and reliable screening test for assessing salivary flow rate and oral dryness, although the spitting test was determined to be highly reliable. MDPI 2020-09-02 /pmc/articles/PMC7558334/ /pubmed/32887247 http://dx.doi.org/10.3390/dj8030102 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Goto, Takaharu
Kishimoto, Takahiro
Iwawaki, Yuki
Fujimoto, Keiko
Ishida, Yuichi
Watanabe, Megumi
Nagao, Kan
Ichikawa, Tetsuo
Reliability of Screening Methods to Diagnose Oral Dryness and Evaluate Saliva Secretion
title Reliability of Screening Methods to Diagnose Oral Dryness and Evaluate Saliva Secretion
title_full Reliability of Screening Methods to Diagnose Oral Dryness and Evaluate Saliva Secretion
title_fullStr Reliability of Screening Methods to Diagnose Oral Dryness and Evaluate Saliva Secretion
title_full_unstemmed Reliability of Screening Methods to Diagnose Oral Dryness and Evaluate Saliva Secretion
title_short Reliability of Screening Methods to Diagnose Oral Dryness and Evaluate Saliva Secretion
title_sort reliability of screening methods to diagnose oral dryness and evaluate saliva secretion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558334/
https://www.ncbi.nlm.nih.gov/pubmed/32887247
http://dx.doi.org/10.3390/dj8030102
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