Cargando…

Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice

Non-invasive brain delivery of neurotherapeutics is challenging due to the blood-brain barrier. The revived interest in transferrin receptor antibodies (TfRMAbs) as brain drug-delivery vectors has revealed the effect of dosing regimen, valency, and affinity on brain uptake, TfR expression, and Fc-ef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Castellanos, Demi M., Sun, Jiahong, Yang, Joshua, Ou, Weijun, Zambon, Alexander C., Pardridge, William M., Sumbria, Rachita K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558337/ https://www.ncbi.nlm.nih.gov/pubmed/32911688 http://dx.doi.org/10.3390/pharmaceutics12090852

Ejemplares similares

The Effects of a Blood–Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy
por: Yang, Joshua, et al.
Publicado: (2023)

Hematologic safety of chronic brain-penetrating erythropoietin dosing in APP/PS1 mice
por: Sun, Jiahong, et al.
Publicado: (2019)

Targeting the transferrin receptor to develop erythropoietin for Alzheimer's disease
por: Sumbria, Rachita K.
Publicado: (2020)

Biologic TNF-α inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy
por: Ou, Weijun, et al.
Publicado: (2021)

Kinetics of Blood–Brain Barrier Transport of Monoclonal Antibodies Targeting the Insulin Receptor and the Transferrin Receptor
por: Pardridge, William M.
Publicado: (2021)

Comparative studies between the murine immortalized brain endothelial cell line (bEnd.3) and induced pluripotent stem cell-derived human brain endothelial cells for paracellular transport
por: Sun, Jiahong, et al.
Publicado: (2022)

Mathematical Models of Blood-Brain Barrier Transport of Monoclonal Antibodies Targeting the Transferrin Receptor and the Insulin Receptor
por: Pardridge, William M., et al.
Publicado: (2021)

Efficacy and Safety of a Brain-Penetrant Biologic TNF-α Inhibitor in Aged APP/PS1 Mice
por: Ou, Weijun, et al.
Publicado: (2022)

Plasmid DNA gene therapy of the Niemann-Pick C1 mouse with transferrin receptor-targeted Trojan horse liposomes
por: Jiang, Dahai, et al.
Publicado: (2020)

High-Affinity Single-Domain Antibodies for Analyzing Human Apo- and Holo-Transferrin
por: Tillib, S. V., et al.
Publicado: (2022)

The concentration of brain homogenates with the Amicon Ultra Centrifugal filters
por: Yang, Joshua, et al.
Publicado: (2021)

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles
por: Johnsen, Kasper Bendix, et al.
Publicado: (2018)

Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis
por: Chang, Hsueh-Yuan, et al.
Publicado: (2021)

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
por: Bien-Ly, Nga, et al.
Publicado: (2014)

Brain Endothelial Erythrophagocytosis and Hemoglobin Transmigration Across Brain Endothelium: Implications for Pathogenesis of Cerebral Microbleeds
por: Chang, Rudy, et al.
Publicado: (2018)

Antigen-binding affinity and thermostability of chimeric mouse-chicken IgY and mouse-human IgG antibodies with identical variable domains
por: Choi, Juho, et al.
Publicado: (2019)

Polymorphic Region-Specific Antibody for Evaluation of Affinity-Associated Profile of Chimeric Antigen Receptor
por: Han, Chungyong, et al.
Publicado: (2020)

Tumor necrosis factor α Inhibition for Alzheimer’s Disease
por: Chang, Rudy, et al.
Publicado: (2017)

Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo
por: Zhang, Hai, et al.
Publicado: (2023)

Receptor-mediated drug delivery of bispecific therapeutic antibodies through the blood-brain barrier
por: Pardridge, William M.
Publicado: (2023)

Aging exacerbates development of cerebral microbleeds in a mouse model
por: Sumbria, Rachita K., et al.
Publicado: (2018)

Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood–brain barrier in vitro is dependent on its binding affinity
por: Haqqani, Arsalan S., et al.
Publicado: (2018)

Expression of a functional mouse-human chimeric anti-CD19 antibody in the milk of transgenic mice
por: van Kuik-Romeijn, Petra, et al.
Publicado: (2000)

Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle
por: Barrientos, Tomasa, et al.
Publicado: (2015)

Alcohol as a Modifiable Risk Factor for Alzheimer’s Disease—Evidence from Experimental Studies
por: Chandrashekar, Devaraj V., et al.
Publicado: (2023)

An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity
por: Maus, Marcela V, et al.
Publicado: (2017)

Human/mouse chimeric antibodies show low reactivity with human anti-murine antibodies (HAMA).
por: Hosono, M., et al.
Publicado: (1992)

A Simple Methodology for Conversion of Mouse Monoclonal Antibody to Human-Mouse Chimeric Form
por: Dang, Vinh T., et al.
Publicado: (2013)

Effects of Dabigatran in Mouse Models of Aging and Cerebral Amyloid Angiopathy
por: Michael, Neethu, et al.
Publicado: (2019)

The immunogenicity of chimeric antibodies
Publicado: (1989)

Rapid endocytosis of the transferrin receptor in the absence of bound transferrin
Publicado: (1985)

Investigating a chimeric anti-mouse PDGFRα antibody as a radiosensitizer in primary mouse sarcomas
por: Song, Erin J., et al.
Publicado: (2019)

Therapeutic Bispecific T-Cell Engager Antibody Targeting the Transferrin Receptor
por: Fu, Mingpeng, et al.
Publicado: (2019)

Different biodistribution of 99mTc-labelled chimeric mouse-human monoclonal antibody between athymic mice model and human.
por: Oriuchi, N., et al.
Publicado: (1996)

Human-murine chimeric autoantibodies with high affinity and specificity for systemic sclerosis
por: Chen, Sunhui, et al.
Publicado: (2023)

Insights Into the Mechanisms of Brain Endothelial Erythrophagocytosis
por: Sun, Jiahong, et al.
Publicado: (2021)

Role of transferrin, transferrin receptors, and iron in macrophage listericidal activity
Publicado: (1991)

The structural basis of transferrin sequestration by transferrin-binding protein B
por: Calmettes, Charles, et al.
Publicado: (2012)

Production, Binding and Cytotoxicity of Human/Mouse Chimeric Monoclonal Antibody‐Neocarzinostatin Conjugate
por: Yamaguchi, Toshiharu, et al.
Publicado: (1993)

Universal chimeric Fcγ receptor T cells with appropriate affinity for IgG1 antibody exhibit optimal antitumor efficacy
por: Zhu, Wen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tdn2j797jb7o9sqll6gb8gc9gb