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Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice

Non-invasive brain delivery of neurotherapeutics is challenging due to the blood-brain barrier. The revived interest in transferrin receptor antibodies (TfRMAbs) as brain drug-delivery vectors has revealed the effect of dosing regimen, valency, and affinity on brain uptake, TfR expression, and Fc-ef...

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Detalles Bibliográficos
Autores principales:	Castellanos, Demi M., Sun, Jiahong, Yang, Joshua, Ou, Weijun, Zambon, Alexander C., Pardridge, William M., Sumbria, Rachita K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558337/ https://www.ncbi.nlm.nih.gov/pubmed/32911688 http://dx.doi.org/10.3390/pharmaceutics12090852

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