Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance

The rising incidence of bloodstream infections (BSI) due to Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) has been recognized as a global emergency. The aim of this review is to provide a comprehensive assessment of the mechanisms of antibiotic resistance, epidemiology and tr...

Descripción completa

Detalles Bibliográficos
Autores principales: Bassetti, Matteo, Vena, Antonio, Sepulcri, Chiara, Giacobbe, Daniele Roberto, Peghin, Maddalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558339/
https://www.ncbi.nlm.nih.gov/pubmed/32971809
http://dx.doi.org/10.3390/antibiotics9090632
_version_ 1783594619745861632
author Bassetti, Matteo
Vena, Antonio
Sepulcri, Chiara
Giacobbe, Daniele Roberto
Peghin, Maddalena
author_facet Bassetti, Matteo
Vena, Antonio
Sepulcri, Chiara
Giacobbe, Daniele Roberto
Peghin, Maddalena
author_sort Bassetti, Matteo
collection PubMed
description The rising incidence of bloodstream infections (BSI) due to Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) has been recognized as a global emergency. The aim of this review is to provide a comprehensive assessment of the mechanisms of antibiotic resistance, epidemiology and treatment options for BSI caused by GNB with DTR, namely extended-spectrum Beta-lactamase-producing Enterobacteriales; carbapenem-resistant Enterobacteriales; DTR Pseudomonas aeruginosa; and DTR Acinetobacter baumannii.
format Online
Article
Text
id pubmed-7558339
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75583392020-10-22 Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance Bassetti, Matteo Vena, Antonio Sepulcri, Chiara Giacobbe, Daniele Roberto Peghin, Maddalena Antibiotics (Basel) Review The rising incidence of bloodstream infections (BSI) due to Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) has been recognized as a global emergency. The aim of this review is to provide a comprehensive assessment of the mechanisms of antibiotic resistance, epidemiology and treatment options for BSI caused by GNB with DTR, namely extended-spectrum Beta-lactamase-producing Enterobacteriales; carbapenem-resistant Enterobacteriales; DTR Pseudomonas aeruginosa; and DTR Acinetobacter baumannii. MDPI 2020-09-22 /pmc/articles/PMC7558339/ /pubmed/32971809 http://dx.doi.org/10.3390/antibiotics9090632 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bassetti, Matteo
Vena, Antonio
Sepulcri, Chiara
Giacobbe, Daniele Roberto
Peghin, Maddalena
Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance
title Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance
title_full Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance
title_fullStr Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance
title_full_unstemmed Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance
title_short Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance
title_sort treatment of bloodstream infections due to gram-negative bacteria with difficult-to-treat resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558339/
https://www.ncbi.nlm.nih.gov/pubmed/32971809
http://dx.doi.org/10.3390/antibiotics9090632
work_keys_str_mv AT bassettimatteo treatmentofbloodstreaminfectionsduetogramnegativebacteriawithdifficulttotreatresistance
AT venaantonio treatmentofbloodstreaminfectionsduetogramnegativebacteriawithdifficulttotreatresistance
AT sepulcrichiara treatmentofbloodstreaminfectionsduetogramnegativebacteriawithdifficulttotreatresistance
AT giacobbedanieleroberto treatmentofbloodstreaminfectionsduetogramnegativebacteriawithdifficulttotreatresistance
AT peghinmaddalena treatmentofbloodstreaminfectionsduetogramnegativebacteriawithdifficulttotreatresistance

Ejemplares similares