Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?

Zn(II) is an inhibitor of SARS-CoV-2′s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores–this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment o...

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Detalles Bibliográficos
Autores principales: Hecel, Aleksandra, Ostrowska, Małgorzata, Stokowa-Sołtys, Kamila, Wątły, Joanna, Dudek, Dorota, Miller, Adriana, Potocki, Sławomir, Matera-Witkiewicz, Agnieszka, Dominguez-Martin, Alicia, Kozłowski, Henryk, Rowińska-Żyrek, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558363/
https://www.ncbi.nlm.nih.gov/pubmed/32882888
http://dx.doi.org/10.3390/ph13090228
Descripción
Sumario:Zn(II) is an inhibitor of SARS-CoV-2′s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores–this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics.

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