Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?

Zn(II) is an inhibitor of SARS-CoV-2′s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores–this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment o...

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Autores principales: Hecel, Aleksandra, Ostrowska, Małgorzata, Stokowa-Sołtys, Kamila, Wątły, Joanna, Dudek, Dorota, Miller, Adriana, Potocki, Sławomir, Matera-Witkiewicz, Agnieszka, Dominguez-Martin, Alicia, Kozłowski, Henryk, Rowińska-Żyrek, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558363/
https://www.ncbi.nlm.nih.gov/pubmed/32882888
http://dx.doi.org/10.3390/ph13090228
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author Hecel, Aleksandra
Ostrowska, Małgorzata
Stokowa-Sołtys, Kamila
Wątły, Joanna
Dudek, Dorota
Miller, Adriana
Potocki, Sławomir
Matera-Witkiewicz, Agnieszka
Dominguez-Martin, Alicia
Kozłowski, Henryk
Rowińska-Żyrek, Magdalena
author_facet Hecel, Aleksandra
Ostrowska, Małgorzata
Stokowa-Sołtys, Kamila
Wątły, Joanna
Dudek, Dorota
Miller, Adriana
Potocki, Sławomir
Matera-Witkiewicz, Agnieszka
Dominguez-Martin, Alicia
Kozłowski, Henryk
Rowińska-Żyrek, Magdalena
author_sort Hecel, Aleksandra
collection PubMed
description Zn(II) is an inhibitor of SARS-CoV-2′s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores–this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics.
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spelling pubmed-75583632020-10-22 Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19? Hecel, Aleksandra Ostrowska, Małgorzata Stokowa-Sołtys, Kamila Wątły, Joanna Dudek, Dorota Miller, Adriana Potocki, Sławomir Matera-Witkiewicz, Agnieszka Dominguez-Martin, Alicia Kozłowski, Henryk Rowińska-Żyrek, Magdalena Pharmaceuticals (Basel) Review Zn(II) is an inhibitor of SARS-CoV-2′s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores–this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics. MDPI 2020-09-01 /pmc/articles/PMC7558363/ /pubmed/32882888 http://dx.doi.org/10.3390/ph13090228 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hecel, Aleksandra
Ostrowska, Małgorzata
Stokowa-Sołtys, Kamila
Wątły, Joanna
Dudek, Dorota
Miller, Adriana
Potocki, Sławomir
Matera-Witkiewicz, Agnieszka
Dominguez-Martin, Alicia
Kozłowski, Henryk
Rowińska-Żyrek, Magdalena
Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?
title Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?
title_full Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?
title_fullStr Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?
title_full_unstemmed Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?
title_short Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?
title_sort zinc(ii)—the overlooked éminence grise of chloroquine’s fight against covid-19?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558363/
https://www.ncbi.nlm.nih.gov/pubmed/32882888
http://dx.doi.org/10.3390/ph13090228
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