Cargando…
Hif-1α Inhibitors Could Successfully Inhibit the Progression of Differentiated Thyroid Cancer in Vitro
Hypoxia-inducible factor (HIF)-1α plays an important role in cancer progression. In various cancers, including thyroid cancer, overexpression of HIF-1α is related to poor prognosis or treatment response. However, few studies have investigated the role of HIF-1α inhibition in thyroid cancer progressi...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558478/ https://www.ncbi.nlm.nih.gov/pubmed/32847004 http://dx.doi.org/10.3390/ph13090208 |
_version_ | 1783594647138861056 |
---|---|
author | Kim, Min-Hee Lee, Tae Hyeong Lee, Jin Soo Lim, Dong-Jun Lee, Peter Chang-Whan |
author_facet | Kim, Min-Hee Lee, Tae Hyeong Lee, Jin Soo Lim, Dong-Jun Lee, Peter Chang-Whan |
author_sort | Kim, Min-Hee |
collection | PubMed |
description | Hypoxia-inducible factor (HIF)-1α plays an important role in cancer progression. In various cancers, including thyroid cancer, overexpression of HIF-1α is related to poor prognosis or treatment response. However, few studies have investigated the role of HIF-1α inhibition in thyroid cancer progression. We evaluated the utility of the HIF-1α inhibitor IDF-11774 in vitro utilizing two thyroid cancer cell lines, K1 and BCPAP. Both cell lines were tested to elucidate the effects of IDF-11774 on cell proliferation and migration using soft agar and invasion assays. Here, we found that a reduction of HIF-1α expression in BCPAP cells was observed after treatment with IDF-11774 in a dose-dependent manner. Moreover, cell proliferation, migration, and anchorage-independent growth were effectively inhibited by IDF-11774 in BCPAP cells but not in K1 cells. Additionally, invasion of BCPAP but not K1 cells was controlled with IDF-11774 in a dose-dependent manner. Our findings suggest that promoting the degradation of HIF-1α could be a strategy to manage progression and that HIF-1α inhibitors are potent drugs for thyroid cancer treatment. |
format | Online Article Text |
id | pubmed-7558478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75584782020-10-26 Hif-1α Inhibitors Could Successfully Inhibit the Progression of Differentiated Thyroid Cancer in Vitro Kim, Min-Hee Lee, Tae Hyeong Lee, Jin Soo Lim, Dong-Jun Lee, Peter Chang-Whan Pharmaceuticals (Basel) Article Hypoxia-inducible factor (HIF)-1α plays an important role in cancer progression. In various cancers, including thyroid cancer, overexpression of HIF-1α is related to poor prognosis or treatment response. However, few studies have investigated the role of HIF-1α inhibition in thyroid cancer progression. We evaluated the utility of the HIF-1α inhibitor IDF-11774 in vitro utilizing two thyroid cancer cell lines, K1 and BCPAP. Both cell lines were tested to elucidate the effects of IDF-11774 on cell proliferation and migration using soft agar and invasion assays. Here, we found that a reduction of HIF-1α expression in BCPAP cells was observed after treatment with IDF-11774 in a dose-dependent manner. Moreover, cell proliferation, migration, and anchorage-independent growth were effectively inhibited by IDF-11774 in BCPAP cells but not in K1 cells. Additionally, invasion of BCPAP but not K1 cells was controlled with IDF-11774 in a dose-dependent manner. Our findings suggest that promoting the degradation of HIF-1α could be a strategy to manage progression and that HIF-1α inhibitors are potent drugs for thyroid cancer treatment. MDPI 2020-08-24 /pmc/articles/PMC7558478/ /pubmed/32847004 http://dx.doi.org/10.3390/ph13090208 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Min-Hee Lee, Tae Hyeong Lee, Jin Soo Lim, Dong-Jun Lee, Peter Chang-Whan Hif-1α Inhibitors Could Successfully Inhibit the Progression of Differentiated Thyroid Cancer in Vitro |
title | Hif-1α Inhibitors Could Successfully Inhibit the Progression of Differentiated Thyroid Cancer in Vitro |
title_full | Hif-1α Inhibitors Could Successfully Inhibit the Progression of Differentiated Thyroid Cancer in Vitro |
title_fullStr | Hif-1α Inhibitors Could Successfully Inhibit the Progression of Differentiated Thyroid Cancer in Vitro |
title_full_unstemmed | Hif-1α Inhibitors Could Successfully Inhibit the Progression of Differentiated Thyroid Cancer in Vitro |
title_short | Hif-1α Inhibitors Could Successfully Inhibit the Progression of Differentiated Thyroid Cancer in Vitro |
title_sort | hif-1α inhibitors could successfully inhibit the progression of differentiated thyroid cancer in vitro |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558478/ https://www.ncbi.nlm.nih.gov/pubmed/32847004 http://dx.doi.org/10.3390/ph13090208 |
work_keys_str_mv | AT kimminhee hif1ainhibitorscouldsuccessfullyinhibittheprogressionofdifferentiatedthyroidcancerinvitro AT leetaehyeong hif1ainhibitorscouldsuccessfullyinhibittheprogressionofdifferentiatedthyroidcancerinvitro AT leejinsoo hif1ainhibitorscouldsuccessfullyinhibittheprogressionofdifferentiatedthyroidcancerinvitro AT limdongjun hif1ainhibitorscouldsuccessfullyinhibittheprogressionofdifferentiatedthyroidcancerinvitro AT leepeterchangwhan hif1ainhibitorscouldsuccessfullyinhibittheprogressionofdifferentiatedthyroidcancerinvitro |