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The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation

Ganglioside GM1 is the most common brain ganglioside enriched in plasma membrane regions known as lipid rafts or membrane microdomains. GM1 participates in many modulatory and communication functions associated with the development, differentiation, and protection of neuronal tissue. It has, however...

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Autores principales: Rudajev, Vladimir, Novotny, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558528/
https://www.ncbi.nlm.nih.gov/pubmed/32916822
http://dx.doi.org/10.3390/membranes10090226
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author Rudajev, Vladimir
Novotny, Jiri
author_facet Rudajev, Vladimir
Novotny, Jiri
author_sort Rudajev, Vladimir
collection PubMed
description Ganglioside GM1 is the most common brain ganglioside enriched in plasma membrane regions known as lipid rafts or membrane microdomains. GM1 participates in many modulatory and communication functions associated with the development, differentiation, and protection of neuronal tissue. It has, however, been demonstrated that GM1 plays a negative role in the pathophysiology of Alzheimer’s disease (AD). The two features of AD are the formation of intracellular neurofibrillary bodies and the accumulation of extracellular amyloid β (Aβ). Aβ is a peptide characterized by intrinsic conformational flexibility. Depending on its partners, Aβ can adopt different spatial arrangements. GM1 has been shown to induce specific changes in the spatial organization of Aβ, which lead to enhanced peptide accumulation and deleterious effect especially on neuronal membranes containing clusters of this ganglioside. Changes in GM1 levels and distribution during the development of AD may contribute to the aggravation of the disease.
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spelling pubmed-75585282020-10-26 The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation Rudajev, Vladimir Novotny, Jiri Membranes (Basel) Review Ganglioside GM1 is the most common brain ganglioside enriched in plasma membrane regions known as lipid rafts or membrane microdomains. GM1 participates in many modulatory and communication functions associated with the development, differentiation, and protection of neuronal tissue. It has, however, been demonstrated that GM1 plays a negative role in the pathophysiology of Alzheimer’s disease (AD). The two features of AD are the formation of intracellular neurofibrillary bodies and the accumulation of extracellular amyloid β (Aβ). Aβ is a peptide characterized by intrinsic conformational flexibility. Depending on its partners, Aβ can adopt different spatial arrangements. GM1 has been shown to induce specific changes in the spatial organization of Aβ, which lead to enhanced peptide accumulation and deleterious effect especially on neuronal membranes containing clusters of this ganglioside. Changes in GM1 levels and distribution during the development of AD may contribute to the aggravation of the disease. MDPI 2020-09-09 /pmc/articles/PMC7558528/ /pubmed/32916822 http://dx.doi.org/10.3390/membranes10090226 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rudajev, Vladimir
Novotny, Jiri
The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation
title The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation
title_full The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation
title_fullStr The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation
title_full_unstemmed The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation
title_short The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation
title_sort role of lipid environment in ganglioside gm1-induced amyloid β aggregation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558528/
https://www.ncbi.nlm.nih.gov/pubmed/32916822
http://dx.doi.org/10.3390/membranes10090226
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