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Saponin Micelles Lead to High Mucosal Permeation and In Vivo Efficacy of Solubilized Budesonide

Due to fast nasal mucociliary clearance, only the dissolved drug content can effectively permeate the mucosa and be pharmaceutically active after intranasal application of suspensions. Therefore, the aim of this study was to increase the budesonide concentration in solution of a nasal spray formulat...

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Detalles Bibliográficos
Autores principales:	Nakowitsch, Sabine, Koller, Christiane, Seifert, Jan-Marcus, König-Schuster, Marielle, Unger-Manhart, Nicole, Siegl, Cornelia, Kirchoff, Norman, Foglar, Elisabeth, Graf, Christine, Morokutti-Kurz, Martina, Neurath, Marianne, Sladek, Svenja, Knecht, Christian, Sipos, Wolfgang, Prieschl-Grassauer, Eva, Grassauer, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558607/ https://www.ncbi.nlm.nih.gov/pubmed/32899549 http://dx.doi.org/10.3390/pharmaceutics12090847

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