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Disease-Specific Autoantibodies Induce Trained Immunity in RA Synovial Tissues and Its Gene Signature Correlates with the Response to Clinical Therapy

Much evidence suggests that trained immunity is inappropriately activated in the synovial tissue in rheumatoid arthritis (RA), but the underlying mechanism remains unclear. Here, we describe how RA-specific autoantibody deposits can train human monocytes to exert the hyperactive inflammatory respons...

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Detalles Bibliográficos
Autores principales:	Dai, Xiaoli, Dai, Xiaoqiu, Gong, Zheng, Yang, Chen, Zeng, Keqin, Gong, Fang-Yuan, Zhong, Qiao, Gao, Xiao-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558774/ https://www.ncbi.nlm.nih.gov/pubmed/33082707 http://dx.doi.org/10.1155/2020/2109325

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