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Glycoprotein- and Lectin-Based Approaches for Detection of Pathogens

Infectious diseases alone are estimated to result in approximately 40% of the 50 million total annual deaths globally. The importance of basic research in the control of emerging and re-emerging diseases cannot be overemphasized. However, new nanotechnology-based methodologies exploiting unique surf...

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Autores principales: Hassan, Sammer-ul, Donia, Ahmed, Sial, Usman, Zhang, Xunli, Bokhari, Habib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558909/
https://www.ncbi.nlm.nih.gov/pubmed/32847039
http://dx.doi.org/10.3390/pathogens9090694
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author Hassan, Sammer-ul
Donia, Ahmed
Sial, Usman
Zhang, Xunli
Bokhari, Habib
author_facet Hassan, Sammer-ul
Donia, Ahmed
Sial, Usman
Zhang, Xunli
Bokhari, Habib
author_sort Hassan, Sammer-ul
collection PubMed
description Infectious diseases alone are estimated to result in approximately 40% of the 50 million total annual deaths globally. The importance of basic research in the control of emerging and re-emerging diseases cannot be overemphasized. However, new nanotechnology-based methodologies exploiting unique surface-located glycoproteins or their patterns can be exploited to detect pathogens at the point of use or on-site with high specificity and sensitivity. These technologies will, therefore, affect our ability in the future to more accurately assess risk. The critical challenge is making these new methodologies cost-effective, as well as simple to use, for the diagnostics industry and public healthcare providers. Miniaturization of biochemical assays in lab-on-a-chip devices has emerged as a promising tool. Miniaturization has the potential to shape modern biotechnology and how point-of-care testing of infectious diseases will be performed by developing smart microdevices that require minute amounts of sample and reagents and are cost-effective, robust, and sensitive and specific. The current review provides a short overview of some of the futuristic approaches using simple molecular interactions between glycoproteins and glycoprotein-binding molecules for the efficient and rapid detection of various pathogens at the point of use, advancing the emerging field of glyconanodiagnostics.
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spelling pubmed-75589092020-10-26 Glycoprotein- and Lectin-Based Approaches for Detection of Pathogens Hassan, Sammer-ul Donia, Ahmed Sial, Usman Zhang, Xunli Bokhari, Habib Pathogens Review Infectious diseases alone are estimated to result in approximately 40% of the 50 million total annual deaths globally. The importance of basic research in the control of emerging and re-emerging diseases cannot be overemphasized. However, new nanotechnology-based methodologies exploiting unique surface-located glycoproteins or their patterns can be exploited to detect pathogens at the point of use or on-site with high specificity and sensitivity. These technologies will, therefore, affect our ability in the future to more accurately assess risk. The critical challenge is making these new methodologies cost-effective, as well as simple to use, for the diagnostics industry and public healthcare providers. Miniaturization of biochemical assays in lab-on-a-chip devices has emerged as a promising tool. Miniaturization has the potential to shape modern biotechnology and how point-of-care testing of infectious diseases will be performed by developing smart microdevices that require minute amounts of sample and reagents and are cost-effective, robust, and sensitive and specific. The current review provides a short overview of some of the futuristic approaches using simple molecular interactions between glycoproteins and glycoprotein-binding molecules for the efficient and rapid detection of various pathogens at the point of use, advancing the emerging field of glyconanodiagnostics. MDPI 2020-08-24 /pmc/articles/PMC7558909/ /pubmed/32847039 http://dx.doi.org/10.3390/pathogens9090694 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hassan, Sammer-ul
Donia, Ahmed
Sial, Usman
Zhang, Xunli
Bokhari, Habib
Glycoprotein- and Lectin-Based Approaches for Detection of Pathogens
title Glycoprotein- and Lectin-Based Approaches for Detection of Pathogens
title_full Glycoprotein- and Lectin-Based Approaches for Detection of Pathogens
title_fullStr Glycoprotein- and Lectin-Based Approaches for Detection of Pathogens
title_full_unstemmed Glycoprotein- and Lectin-Based Approaches for Detection of Pathogens
title_short Glycoprotein- and Lectin-Based Approaches for Detection of Pathogens
title_sort glycoprotein- and lectin-based approaches for detection of pathogens
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558909/
https://www.ncbi.nlm.nih.gov/pubmed/32847039
http://dx.doi.org/10.3390/pathogens9090694
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