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Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol

Knowledge of the survival and stability of a pathogen is important for understanding its risk, reducing its transmission, and establishing control measures. Lassa virus is endemic in West Africa, causes severe disease, and is an emerging pathogen of concern. Our study examined the survival of Lassa...

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Autores principales: Smither, Sophie J, Eastaugh, Lin S, Findlay, James S, O’Brien, Lyn M, Lever, Mark S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558936/
https://www.ncbi.nlm.nih.gov/pubmed/32825610
http://dx.doi.org/10.3390/pathogens9090680
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author Smither, Sophie J
Eastaugh, Lin S
Findlay, James S
O’Brien, Lyn M
Lever, Mark S
author_facet Smither, Sophie J
Eastaugh, Lin S
Findlay, James S
O’Brien, Lyn M
Lever, Mark S
author_sort Smither, Sophie J
collection PubMed
description Knowledge of the survival and stability of a pathogen is important for understanding its risk, reducing its transmission, and establishing control measures. Lassa virus is endemic in West Africa, causes severe disease, and is an emerging pathogen of concern. Our study examined the survival of Lassa virus in blood and tissue culture media at two different temperatures. The stability of Lassa virus held within a small particle aerosol was also measured. In liquids, Lassa virus was found to decay more quickly at 30 °C compared to room temperature. Sealed samples protected from environmental desiccation were more stable than samples open to the environment. In a small particle aerosol, the decay rate of Lassa virus was determined at 2.69% per minute. This information can contribute to risk assessments and inform mitigation strategies in the event of an outbreak of Lassa virus.
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spelling pubmed-75589362020-10-26 Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol Smither, Sophie J Eastaugh, Lin S Findlay, James S O’Brien, Lyn M Lever, Mark S Pathogens Article Knowledge of the survival and stability of a pathogen is important for understanding its risk, reducing its transmission, and establishing control measures. Lassa virus is endemic in West Africa, causes severe disease, and is an emerging pathogen of concern. Our study examined the survival of Lassa virus in blood and tissue culture media at two different temperatures. The stability of Lassa virus held within a small particle aerosol was also measured. In liquids, Lassa virus was found to decay more quickly at 30 °C compared to room temperature. Sealed samples protected from environmental desiccation were more stable than samples open to the environment. In a small particle aerosol, the decay rate of Lassa virus was determined at 2.69% per minute. This information can contribute to risk assessments and inform mitigation strategies in the event of an outbreak of Lassa virus. MDPI 2020-08-21 /pmc/articles/PMC7558936/ /pubmed/32825610 http://dx.doi.org/10.3390/pathogens9090680 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Smither, Sophie J
Eastaugh, Lin S
Findlay, James S
O’Brien, Lyn M
Lever, Mark S
Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol
title Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol
title_full Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol
title_fullStr Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol
title_full_unstemmed Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol
title_short Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol
title_sort survival of lassa virus in blood and tissue culture media and in a small particle aerosol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558936/
https://www.ncbi.nlm.nih.gov/pubmed/32825610
http://dx.doi.org/10.3390/pathogens9090680
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