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Sweet Selenium: Synthesis and Properties of Selenium-Containing Sugars and Derivatives

In the last decades, organoselenium compounds gained interest due to their important biological features. However, the lack of solubility, which characterizes most of them, makes their actual clinical exploitability a hard to reach goal. Selenosugars, with their intrinsic polarity, do not suffer fro...

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Detalles Bibliográficos
Autores principales: Mangiavacchi, Francesca, Coelho Dias, Italo Franco, Di Lorenzo, Irene, Grzes, Pawel, Palomba, Martina, Rosati, Ornelio, Bagnoli, Luana, Marini, Francesca, Santi, Claudio, Lenardao, Eder Joao, Sancineto, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558951/
https://www.ncbi.nlm.nih.gov/pubmed/32859124
http://dx.doi.org/10.3390/ph13090211
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author Mangiavacchi, Francesca
Coelho Dias, Italo Franco
Di Lorenzo, Irene
Grzes, Pawel
Palomba, Martina
Rosati, Ornelio
Bagnoli, Luana
Marini, Francesca
Santi, Claudio
Lenardao, Eder Joao
Sancineto, Luca
author_facet Mangiavacchi, Francesca
Coelho Dias, Italo Franco
Di Lorenzo, Irene
Grzes, Pawel
Palomba, Martina
Rosati, Ornelio
Bagnoli, Luana
Marini, Francesca
Santi, Claudio
Lenardao, Eder Joao
Sancineto, Luca
author_sort Mangiavacchi, Francesca
collection PubMed
description In the last decades, organoselenium compounds gained interest due to their important biological features. However, the lack of solubility, which characterizes most of them, makes their actual clinical exploitability a hard to reach goal. Selenosugars, with their intrinsic polarity, do not suffer from this issue and as a result, they can be conceived as a useful alternative. The aim of this review is to provide basic knowledge of the synthetic aspects of selenosugars, selenonium salts, selenoglycosides, and selenonucleotides. Their biological properties will be briefly detailed. Of course, it will not be a comprehensive dissertation but an analysis of what the authors think is the cream of the crop of this interesting research topic.
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spelling pubmed-75589512020-10-26 Sweet Selenium: Synthesis and Properties of Selenium-Containing Sugars and Derivatives Mangiavacchi, Francesca Coelho Dias, Italo Franco Di Lorenzo, Irene Grzes, Pawel Palomba, Martina Rosati, Ornelio Bagnoli, Luana Marini, Francesca Santi, Claudio Lenardao, Eder Joao Sancineto, Luca Pharmaceuticals (Basel) Review In the last decades, organoselenium compounds gained interest due to their important biological features. However, the lack of solubility, which characterizes most of them, makes their actual clinical exploitability a hard to reach goal. Selenosugars, with their intrinsic polarity, do not suffer from this issue and as a result, they can be conceived as a useful alternative. The aim of this review is to provide basic knowledge of the synthetic aspects of selenosugars, selenonium salts, selenoglycosides, and selenonucleotides. Their biological properties will be briefly detailed. Of course, it will not be a comprehensive dissertation but an analysis of what the authors think is the cream of the crop of this interesting research topic. MDPI 2020-08-26 /pmc/articles/PMC7558951/ /pubmed/32859124 http://dx.doi.org/10.3390/ph13090211 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mangiavacchi, Francesca
Coelho Dias, Italo Franco
Di Lorenzo, Irene
Grzes, Pawel
Palomba, Martina
Rosati, Ornelio
Bagnoli, Luana
Marini, Francesca
Santi, Claudio
Lenardao, Eder Joao
Sancineto, Luca
Sweet Selenium: Synthesis and Properties of Selenium-Containing Sugars and Derivatives
title Sweet Selenium: Synthesis and Properties of Selenium-Containing Sugars and Derivatives
title_full Sweet Selenium: Synthesis and Properties of Selenium-Containing Sugars and Derivatives
title_fullStr Sweet Selenium: Synthesis and Properties of Selenium-Containing Sugars and Derivatives
title_full_unstemmed Sweet Selenium: Synthesis and Properties of Selenium-Containing Sugars and Derivatives
title_short Sweet Selenium: Synthesis and Properties of Selenium-Containing Sugars and Derivatives
title_sort sweet selenium: synthesis and properties of selenium-containing sugars and derivatives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558951/
https://www.ncbi.nlm.nih.gov/pubmed/32859124
http://dx.doi.org/10.3390/ph13090211
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