Lineage tracing: technology tool for exploring the development, regeneration, and disease of the digestive system

Lineage tracing is the most widely used technique to track the migration, proliferation, and differentiation of specific cells in vivo. The currently available gene-targeting technologies have been developing for decades to study organogenesis, tissue injury repairing, and tumor progression by traci...

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Autores principales: Zhang, Yue, Zeng, Fanhong, Han, Xu, Weng, Jun, Gao, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559019/
https://www.ncbi.nlm.nih.gov/pubmed/33059752
http://dx.doi.org/10.1186/s13287-020-01941-y
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author Zhang, Yue
Zeng, Fanhong
Han, Xu
Weng, Jun
Gao, Yi
author_facet Zhang, Yue
Zeng, Fanhong
Han, Xu
Weng, Jun
Gao, Yi
author_sort Zhang, Yue
collection PubMed
description Lineage tracing is the most widely used technique to track the migration, proliferation, and differentiation of specific cells in vivo. The currently available gene-targeting technologies have been developing for decades to study organogenesis, tissue injury repairing, and tumor progression by tracing the fates of individual cells. Recently, lineage tracing has expanded the platforms available for disease model establishment, drug screening, cell plasticity research, and personalized medicine development in a molecular and cellular biology perspective. Lineage tracing provides new views for exploring digestive organ development and regeneration and techniques for digestive disease causes and progression. This review focuses on the lineage tracing technology and its application in digestive diseases.
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spelling pubmed-75590192020-10-15 Lineage tracing: technology tool for exploring the development, regeneration, and disease of the digestive system Zhang, Yue Zeng, Fanhong Han, Xu Weng, Jun Gao, Yi Stem Cell Res Ther Review Lineage tracing is the most widely used technique to track the migration, proliferation, and differentiation of specific cells in vivo. The currently available gene-targeting technologies have been developing for decades to study organogenesis, tissue injury repairing, and tumor progression by tracing the fates of individual cells. Recently, lineage tracing has expanded the platforms available for disease model establishment, drug screening, cell plasticity research, and personalized medicine development in a molecular and cellular biology perspective. Lineage tracing provides new views for exploring digestive organ development and regeneration and techniques for digestive disease causes and progression. This review focuses on the lineage tracing technology and its application in digestive diseases. BioMed Central 2020-10-15 /pmc/articles/PMC7559019/ /pubmed/33059752 http://dx.doi.org/10.1186/s13287-020-01941-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Yue
Zeng, Fanhong
Han, Xu
Weng, Jun
Gao, Yi
Lineage tracing: technology tool for exploring the development, regeneration, and disease of the digestive system
title Lineage tracing: technology tool for exploring the development, regeneration, and disease of the digestive system
title_full Lineage tracing: technology tool for exploring the development, regeneration, and disease of the digestive system
title_fullStr Lineage tracing: technology tool for exploring the development, regeneration, and disease of the digestive system
title_full_unstemmed Lineage tracing: technology tool for exploring the development, regeneration, and disease of the digestive system
title_short Lineage tracing: technology tool for exploring the development, regeneration, and disease of the digestive system
title_sort lineage tracing: technology tool for exploring the development, regeneration, and disease of the digestive system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559019/
https://www.ncbi.nlm.nih.gov/pubmed/33059752
http://dx.doi.org/10.1186/s13287-020-01941-y
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