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Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses
Mycobacterial infections are a resurgent and increasingly relevant problem. Within these, tuberculosis (TB) is particularly worrying as it is one of the top ten causes of death in the world and is the infectious disease that causes the highest number of deaths. A further concern is the on-going emer...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559022/ https://www.ncbi.nlm.nih.gov/pubmed/32887358 http://dx.doi.org/10.3390/antibiotics9090569 |
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author | Simões, Marta Filipa Ottoni, Cristiane Angélica Antunes, André |
author_facet | Simões, Marta Filipa Ottoni, Cristiane Angélica Antunes, André |
author_sort | Simões, Marta Filipa |
collection | PubMed |
description | Mycobacterial infections are a resurgent and increasingly relevant problem. Within these, tuberculosis (TB) is particularly worrying as it is one of the top ten causes of death in the world and is the infectious disease that causes the highest number of deaths. A further concern is the on-going emergence of antimicrobial resistance, which seriously limits treatment. The COVID-19 pandemic has worsened current circumstances and future infections will be more incident. It is urgent to plan, draw solutions, and act to mitigate these issues, namely by exploring new approaches. The aims of this review are to showcase the extensive research and application of silver nanoparticles (AgNPs) and other metal nanoparticles (MNPs) as antimicrobial agents. We highlight the advantages of mycogenic synthesis, and report on their underexplored potential as agents in the fight against all mycobacterioses (non-tuberculous mycobacterial infections as well as TB). We propose further exploration of this field. |
format | Online Article Text |
id | pubmed-7559022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75590222020-10-26 Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses Simões, Marta Filipa Ottoni, Cristiane Angélica Antunes, André Antibiotics (Basel) Review Mycobacterial infections are a resurgent and increasingly relevant problem. Within these, tuberculosis (TB) is particularly worrying as it is one of the top ten causes of death in the world and is the infectious disease that causes the highest number of deaths. A further concern is the on-going emergence of antimicrobial resistance, which seriously limits treatment. The COVID-19 pandemic has worsened current circumstances and future infections will be more incident. It is urgent to plan, draw solutions, and act to mitigate these issues, namely by exploring new approaches. The aims of this review are to showcase the extensive research and application of silver nanoparticles (AgNPs) and other metal nanoparticles (MNPs) as antimicrobial agents. We highlight the advantages of mycogenic synthesis, and report on their underexplored potential as agents in the fight against all mycobacterioses (non-tuberculous mycobacterial infections as well as TB). We propose further exploration of this field. MDPI 2020-09-02 /pmc/articles/PMC7559022/ /pubmed/32887358 http://dx.doi.org/10.3390/antibiotics9090569 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Simões, Marta Filipa Ottoni, Cristiane Angélica Antunes, André Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses |
title | Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses |
title_full | Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses |
title_fullStr | Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses |
title_full_unstemmed | Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses |
title_short | Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses |
title_sort | mycogenic metal nanoparticles for the treatment of mycobacterioses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559022/ https://www.ncbi.nlm.nih.gov/pubmed/32887358 http://dx.doi.org/10.3390/antibiotics9090569 |
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